Jack Della Maddalena vs. Islam Makhachev Prediction, Betting Pick, Latest UFC 322 Odds for Lightweight Title
Islam Makhchev has been a superstar in the UFC for nearly a decade, and hasn't lost in years. Can he continue his dominance in the Lightweight title fight at Madison Square Garden? He's heavily favored in this Jack Della Maddalena vs. Makhachev prediction at UFC 322.
Peter Alexis - November 15, 2025, 9:00 PM EST
5 Minute ReadJack Della Maddalena vs. Islam Makhachev Prediction: Can Islam Continue Reign of Dominance at UFC 322
UFC 322 at Madison Square Garden features one of the most anticipated title fights of the year as reigning flyweight champion Valentina Shevchenko defends her belt against former strawweight queen Zhang Weili. The main card begins Saturday at 10 p.m. ET, and this matchup stands out as a clash between two of the most accomplished women in UFC history. With contrasting styles and championship pedigrees, this fight could determine the long term direction of the flyweight division.
Shevchenko enters as a -145 favorite, carrying a remarkable streak of 12 consecutive title fights, winning all but one. She reclaimed her belt immediately at UFC 306, reminding the division why she remains one of the most complete and consistent champions in the sport. Zhang, coming in at +120, brings explosive offense and relentless pressure, but the question is whether that will be enough to unseat one of the most decorated technicians the UFC has ever seen.
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Jack Della Maddalena vs. Islam Makhachev Odds
- Moneyline: Della Maddalena (+245), Makhachev (-275)
Jack Della Maddalena vs. Islam Makhachev Date, Time, and Where to Watch
- Date: Saturday, November 15, 2025
- Time: 10:00 PM ET (Main Card Start)
- Where to Watch: ESPN+
Click here for complete Maddalena vs. Makhachev odds
Della Maddalena vs. Makhachev Prediction
Makhachev’s dominance begins with his suffocating grappling. His chain wrestling, top control, and ability to neutralize opponents round after round have defined his rise to a 27 1 record. His victories over Dustin Poirier and Alexander Volkanovski showed that he can dominate both submission specialists and elite strikers, making him one of the most complete fighters in the sport. If he gets this fight to the mat consistently, the dynamic striking of Della Maddalena may never get the chance to shine.
Della Maddalena’s best path lies in controlling distance and keeping this fight standing as long as possible. His boxing is crisp, accurate, and built around high percentage combinations and body work. He excels in pocket exchanges and can put damaging volume on opponents who struggle with pressure. The challenge is maintaining that rhythm under the constant threat of Makhachev’s takedowns. Few fighters can stay off the fence against Islam for long stretches, and once he establishes control, the rounds tend to slip away quickly.
Another key factor is Makhachev’s growing comfort in extended fights. He has gone five rounds at the championship level multiple times, showing clarity, composure, and excellent cardio. Della Maddalena, while dangerous, has not yet been tested against a grappling force of this caliber. If the fight reaches the later rounds, the advantages in pace, positioning, and physical control tilt heavily toward the champion.
Della Maddalena vs. Makhachev Pick
- Pick: Islam Makhachev to Win by Decision +200 Click here to get the best odds at DraftKings Sportsbook
Della Maddalena is talented enough to land clean shots early, but Makhachev’s experience, pressure, and championship level grappling have broken down far more established opponents. In a bout where positional dominance may matter more than explosive moments, the champion has multiple clear paths to victory.
MMA ODDS & PICKS
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