Joshua Van vs. Alexandre Pantoja Prediction, Betting Pick, Latest UFC 331 Odds for September 19th Main Event
Joshua Van and Alexandre Pantoja meet again with the flyweight championship on the line in Saturday’s UFC 331 main event. Can Pantoja reclaim his belt after an injury abruptly ended their first meeting? Check out this Joshua Van vs. Alexandre Pantoja prediction and best bet for Saturday, September 19.
Peter Alexis - September 19, 2026, 8:00 PM EDT
4 Minute ReadJoshua Van vs. Alexandre Pantoja Prediction: Can Pantoja Get Revenge in UFC 331 Main Event Tonight?
Alexandre Pantoja gets his opportunity to reclaim the flyweight title when he challenges Joshua Van at Crypto.com Arena. The main event is listed for approximately 11:30 p.m. Eastern on Paramount+, with Van favored at -162 and Pantoja available at the selected +135 moneyline price.
The revenge angle requires an important distinction. Their December 2025 meeting ended in an injury-related TKO after Pantoja hurt his arm during an early fall. It was an official stoppage defeat, but it provided very little evidence of how a full fight between these two would unfold.
Joshua Van vs. Alexandre Pantoja Odds
- Moneyline: Van (-160), Pantoja (+135)
Joshua Van vs. Alexandre Pantoja Date, Time, and Where to Watch
- Date: Saturday, September 19th, 2026
- Time: 11:15 PM ET (Estimated Fight Time)
- Where to Watch: Paramount+
Click here for complete Joshua Van vs. Alexandre Pantoja odds
Joshua Van vs. Alexandre Pantoja Prediction
Pantoja’s strongest route is to make the rematch a sustained grappling contest. Closing distance, working through takedown sequences and threatening from dominant positions would prevent Van from settling into the extended striking exchanges that favor the champion.
Van’s challenge is to make those entries expensive. Accurate combinations and disciplined movement can force Pantoja to absorb damage before reaching the clinch. If the challenger repeatedly falls short on takedowns, the physical cost could become increasingly important over five rounds.
Pantoja’s championship experience remains a substantial part of the upset case. Before losing the belt, he demonstrated that he could win lengthy title fights as well as finish opponents on the ground. That variety matters against a champion who cannot afford to prepare only for the initial takedown.
The injury return is a legitimate uncertainty, and the first fight’s unusual ending does not guarantee a different result. Still, Pantoja’s ability to change the terms of the matchup makes him an appealing underdog. The moneyline covers both a submission and a hard-earned decision without requiring an exact finishing method.
Joshua Van vs. Alexandre Pantoja Pick
- Pick: Pantoja Moneyline (+135) Check out these best odds at DraftKings Sportsbook
Pantoja is the selection to reclaim the championship by making his pressure and grappling the central features of the rematch. Van deserves respect as the favorite, but +135 is an attractive price on the former champion getting a proper opportunity to impose his game after last year’s abbreviated meeting.
MMA ODDS & PICKS
Affiliate Disclosure.
We are not a gambling or betting operator, but we receive a commission from these companies when we advertise their brands and refer customers to them (affiliate marketing). We provide information, odds information and links to websites of these companies. Some of the information made available on our site may be positioned as a result of a commission paid to us by a third party. We do not take or place bets/transactions and any information on Our Products is provided for entertainment purposes only.
