USC vs. Colorado Prediction, Pick Against the Spread, and Latest Odds
The USC Trojans and the Colorado Buffaloes meet on Saturday afternoon for a Pac-12 showdown. Who has the advantage? Matt McCuen provides his USC vs. Colorado prediction, pick, and the latest odds.
Matt McCuen - September 29, 2023, 3:00 PM EDT
7 minUSC vs. Colorado Prediction, Pick Against the Spread, and Latest Odds
The USC Trojans and the Colorado Buffaloes will clash from Boulder on Saturday afternoon.
USC vs. Colorado Date, Start Time, and Where to Watch
- Date: September 30, 2023
- Game Time: 12:00 pm ET
- Where to Watch: FOX
USC vs. Colorado Odds
- Spread: USC -21.5 (-106), Colorado +21.5 (-110)
- Total Odds: O 73.5 (-110), U 73.5 (-104)
- Moneyline Odds : USC (-1350), Colorado (+950)
USC vs. Colorado Prediction
This will be a 12 p.m. kickoff, which means this will be an early game for two teams for the Pac-12.
The Trojans enter play with a perfect 4-0 record. USC is ranked eighth overall in the nation.
Quarterback Caleb Williams leads the Trojans. Williams will attempt to win his second consecutive Heisman Trophy award. Williams is the favorite to win the award after four weeks of throwing for 1,200 yards, 15 touchdowns, and zero interceptions.
Marshawn Lloyd has rushed for 349 yards and a pair of touchdowns to lead the team.
Wide receivers Tahj Washington and Brenden Rice have combined for 535 yards and nine receiving touchdowns.
The USC defense has been up and down. If USC figures things out on defense, this is a team that can compete for a national championship.
Colorado has been the most intriguing team in college football through the first month.
Love or hate Colorado; you are invested in what they are doing. There is no team that is bringing in more views than the Buffaloes are.
Head Coach Deion Sanders deserves a ton of credit for what he has done in his first month in Boulder.
The Buffaloes were humbled a week ago, losing 42-6 to Oregon.
This does not mean that the Buffaloes are frauds, but it does pump the brakes on the takes that this is a championship-level team.
Shedeur Sanders leads the Buffalo's offense. Sanders has thrown for 1,410 yards, 11 touchdowns, and one interception.
Dylan Edwards leads the Buffaloes in rushing yards with 157 and one touchdown.
Wide receiver Xavier Weaver has been the favorite target of Sanders, racking up 461 yards and two touchdowns.
The Colorado defense will attempt to bounce back after a poor showing against Oregon.
USC vs. Colorado Pick
This is too many points to give Colorado at home.
The Buffaloes will be well motivated after what they put on display a week ago, and Colorado matches up well in this type of game script.
USC just gave up 28 points to Arizona State.
Colorado is a better scoring offense than Arizona State is and will have an opportunity to score thirty or more points this weekend.
This game will be a shoot out, which means 21.5 points is way too many on the road.
Pick: Colorado +21.5 -110 is currently the best odds. Click here to see which sportsbook has the best odds for this pick
College Football Odds
