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Notre Dame Football Helmets

Notre Dame vs. Duke Prediction, Pick Against the Spread, and Latest Odds

The Notre Dame Fighting Irish face the Duke Blue Devils Saturday night for a pivotal Week 5 matchup. How will this game play out? Matt McCuen shares his Notre Dame vs. Duke prediction, pick, and the latest odds ahead of the game.

Notre Dame vs. Duke Prediction, Pick Against the Spread, and Latest Odds

The Notre Dame Fighting Irish and the Duke Blue Devils will duel things out from Wallace Wade Stadium on Saturday night for a pivotal matchup.

Notre Dame vs. Duke Date, Time, and Where To Watch

  • Date: September 30, 2023
  • Game Time: 7:30 p.m. ET
  • Where to Watch: ABC

Notre Dame vs. Duke Odds

  • Spread: Notre Dame -5 (-115), Duke +5 (-104)
  • Total Odds: Over 52 (-110), Under 52 (-105)
  • Moneyline Odds: Notre Dame (-210), Duke (+180)

Notre Dame vs. Duke Prediction

The Irish can not be happy entering play after a gut-wrenching loss in Week 4.

Notre Dame led the game late, but on the final play of the game, Ohio State found their way into the end zone to silence the crowd in South Bend.

The bad news is the Irish lost the game. The good news is that losing to Ohio State is as good of a loss as you could have on the resume. There is a good chance that if the Irish win out, they can still make the college football playoffs.

Sam Hartman leads the Notre Dame offense. Hartman appears to be a legitimate candidate to win the Heisman Trophy award. Hartman has thrown for 1,236 yards, fourteen touchdowns, and zero interceptions.

There has been no running back in college football better than Audric Estime. Estime has rushed for 591 yards and five touchdowns. Estime is averaging 7.7 yards per rush.

Wide receiver Chris Tyree leads the Irish in receiving yards with a team-best t241 yards and two touchdowns.

The defense for Notre Dame has been one of the best in college football. Linebacker Jack Kiser leads the team with 28 tackles.

Duke enters play with a perfect 4-0 record on the young season.

Duke pulled off a massive win at home in Week 1 over Clemson, which pushed them into the top 25.

Duke has impressed early and has an opportunity to add a program-building win over Notre Dame this weekend.

Quarterback Riley Leonard leads the Blue Devils, throwing for 778 yards and two touchdowns.

Running back Jordan Waters leads the Blue Devils, rushing for 358 yards and a team-best seven touchdowns.

Wide receiver Jalon Calhoun leads the Blue Devils, racking up a team-best 258 yards and one touchdown.

Duke has been solid this year on defense. Cornerback Chandler Rivers leads the squad with 25 tackles.

Notre Dame vs. Duke Pick

The Irish lost a heartbreaker over the weekend, but Notre Dame outplayed a great Ohio State team for most of the game.

Notre Dame is a much better team than Duke, and with their season on the line, they will come out with a chip on their shoulder.

Hartman will be too much for this Duke defense, and the Irish defense will continue their dominance this weekend.

Pick: Notre Dame -5 -115 is currently the best odds. Click here to see which sportsbook has the best odds for this pick

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