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USC vs. LSU Prediction, Pick Against the Spread, Latest Odds for Week 1 Clash in Las Vegas

The USC Trojans will battle the LSU Tigers from Allegiant Stadium on Sunday night in a rare neutral site matchup. Can Miller Moss and the Trojans keep it close and surprise the Tigers? Matt McCuen provides his prediction and pick for this ranked showdown to conclude Week 1 in CFB.

Matt McCuen - September 1, 2024, 9:30 AM EDT

5 min

USC vs. LSU Prediction, Pick Against the Spread, Latest Odds for Week 1 Clash in Las Vegas

The LSU Tigers and the USC Trojans will meet from Las Vegas on Sunday.

We could not ask for a better stand-alone game than this one.

USC vs. LSU Start Time, Where To Watch, Odds

  • Date: Sunday, September 1, 2024
  • Game Time: 7:30 p.m. ET
  • Where to Watch: ABC

USC vs. LSU Odds

  • Spread: USC +4.5 (-110), LSU -4.5 (-110)
  • Total Odds: O 63.5 (-110), U 63.5 (-110)
  • Moneyline Odds: USC (+165), LSU (-200)

USC vs. LSU Prediction

The Tigers come into the year ranked 13th in the nation.

LSU will look to make some noise this season in the SEC.

Head Coach Brian Kelly’s team has the talent to be a part of the playoffs and compete for an SEC Championship.

The Tigers are coming off a season in which they finished 10-3 while claiming their second consecutive bowl win.

Kelly has ripped off back-to-back ten-win seasons in Baton Rouge. Kelly needs to take this LSU team to the playoffs this year with the field expanding.

Garrett Nussmeier will be under center for the Tigers. The Junior threw for 591 yards four touchdowns and one interception last year.

Josh Williams dashed for 284 yards and five touchdowns last year.

CJ Daniels will be the top option in the passing game. The Georgia native racked up 1,067 yards and 10 touchdowns last year.

LSU will look to improve after an up-and-down year on defense in 2024.

USC rolls into the year ranked 23rd in the nation.

2024 is an important season for head coach Lincoln Riley.

Riley’s team went 8-5 last season, with Heisman quarterback Caleb Williams leading the offense.

The Trojans will be challenged in their first season in the Big Ten.

Miller Moss leads the USC offensive unit. Moss threw for 681 yards, seven touchdowns, and one interception last year.

Senior Woody Marks leads the rushing game. Marks rushed for 573 yards and four touchdowns at Mississippi State.

Zachariah Branch will be one of the top options in the passing game. Branch racked up 320 yards and two touchdowns in 2023.

USC vs. LSU Betting Pick

We will take the points with the Trojans tonight.

These two teams are evenly matched in talent, making it a no-brainer.

The Trojan offense will have its way with the Tigers in this game, keeping it close throughout.

Pick: USC +4.5 -110 Click here to see which sportsbook has the best odds

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