Iowa State vs. Kansas State Prediction, Betting Pick, Latest CFB Odds for Week 0 Opener
The Iowa State Cyclones and Kansas State Wildcats will meet in the first ranked battle of the college football season, kicking off Week 0 from Dublin, Ireland. Can Rocco Becht and the Cyclones build off last season's hot start and begin another fight towards a Big 12 Championship appearance? McBets joins us to break down his Iowa State vs. Kansas State prediction for Saturday, August 23rd.
McBets - August 22, 2025, 8:15 PM EDT
5 Minute ReadIowa State vs. Kansas State Prediction, Betting Pick, Latest CFB Odds for Week 0 Opener
Football is back, baby! No better time of year than right now. The energy, the storylines, the rivalries—it’s all here. And what better way to kick off the season than with a massive Big 12 showdown in Dublin, Ireland between Kansas State and Iowa State.
With both teams returning their star quarterbacks, and Iowa State looking to build towards a second-consecutive Big 12 championship appearance, who will find a way to come out on top in this conference opener aborad? McBets has the answer, but let's take a look at the latest Iowa State vs. Kansas State odds first.
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Iowa State vs. Kansas State Odds
Iowa State vs. Kansas State Prediction
Kansas State brings back their headline-grabbing QB, Avery Johnson, a true dual-threat playmaker who can flip a game in a heartbeat. Last season, Iowa State’s defense held him in check, limiting Johnson to a 12-of-28 day with 220 yards. This time, though, Johnson has an experienced offensive line protecting him—one that should open up running lanes and let the Wildcats lean on the physical ground game that carried them so often last year. The one concern? A rebuilt secondary on defense, which could make them vulnerable against the Cyclones’ passing attack.
For Iowa State, Rocco Becht returns under center. He’s electric—capable of ripping off highlight plays, but also prone to costly mistakes. The difference now is experience. He’s been battle-tested, and I expect a more polished version of Becht this season. While the Cyclones lost their top two receivers to the NFL (both to the Texans), reinforcements are ready, and Iowa State’s trademark tight end-heavy sets could shine early. Defensively, it’s business as usual: Matt Campbell’s squads are consistently disciplined, physical, and ready to slow down a dual-threat QB like Johnson.
History also tilts in Campbell’s favor. He’s been dominant in this matchup, covering the spread in five straight meetings against Kansas State and winning four of them outright. With the neutral site in play, the numbers point toward the Cyclones.
Bottom line: expect a dogfight. This feels like the kind of game that swings late—possibly on a single kick. Either way, football is officially back, and Week 0 gives us a classic right out of the gate.
Iowa State vs. Kansas State Pick
- 1.5 Unit Pick: Iowa State +4 (-130) Click here to get the best Iowa State odds at DraftKings Sportsbook
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