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Fresno State vs. Kansas Prediction, Betting Pick, Latest CFB Odds for Week 0 Opener

The Kansas Jayhawks will host the Fresno State Bulldogs in a Week 0 matchup in Lawrence, Kansas on Saturday night. Jalon Daniels is back again for the Jayhawks, can he lead them back to another bowl victory in 2025? Peter Alexis breaks down this Fresno State vs. Kansas prediction and gives a best bet for Saturday, August 23rd.

Fresno State vs. Kansas Prediction, Betting Pick, Latest CFB Odds for Week 0 Opener

Kansas and Fresno State will meet in a Week 0 showdown on Saturday, August 23, 2025, at David Booth Kansas Memorial Stadium in Lawrence, Kansas. The game is set to kick off at 6:30 p.m. ET and promises to be an exciting matchup between two programs on the rise. Both teams had strong showings last season and will be looking to build on that success in the 2025 campaign. Fans can expect an entertaining battle between Kansas’ high-powered offense and Fresno State’s well-balanced team.

Kansas enjoyed its best season in years in 2024, finishing 9-4 overall and winning a bowl game for the first time since 2008. The Jayhawks’ offense was one of the most dynamic in the Big 12, led by quarterback Jalon Daniels, who passed for nearly 2,500 yards and 14 touchdowns while adding 400+ yards on the ground. However, they lose RB Devin Neal, who rushed for over 1,200 yards and 16 touchdowns last season. With a high-flying offense and the return of key skill players, Kansas is expected to be a serious contender in the Big 12 once again. However, the defense remains a question mark, as they gave up an average of 30+ points per game last season, which could be a concern against a team like Fresno State.

Fresno State had a solid 2024 campaign, finishing with an impressive 10-3 record and earning a spot in the Mountain West Championship Game. The Bulldogs lost quarterback Mikey Keene, who transferred to Michigan after throwing for over 2,800 yards and 18 touchdowns last season. Keene was an experienced leader, and Fresno's offense will miss him a lot this year, especially early on. The Bulldogs also lost Jalen Moreno-Cropper, their sotaro receiver of over 1,000 yards to the Dallas Cowboys. With all those missing production, Fresno may struggle to geto the engine going in the beginning of this one.

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Fresno State vs. Kansas Odds

Fresno State vs. Kansas Prediction

The biggest storyline in this game will be the offensive showdown between Kansas' explosive attack and Fresno State's methodical, high-efficiency offense. Kansas has one of the most dangerous offenses in the country, with Jalon Daniels at the helm and a deep group of weapons. However, they will face a tough challenge against Fresno State’s defense, which was one of the best in the Mountain West, ranking in the top 25 in several defensive categories. Kansas will need to be more efficient on defense if they hope to slow down Fresno State’s offense, which can both run and pass the ball with success.

While both teams are strong offensively, it is Fresno State’s defense that could ultimately be the difference. The Bulldogs were 17th in the nation last year in scoring defense, allowing just 20.1 points per game. They have a disciplined, aggressive defense that excels at limiting big plays and forcing turnovers, which could be critical against Kansas' high-paced offense. If Fresno State can control the line of scrimmage and limit Kansas' big-play ability, they will have a strong chance of keeping the game within reach.

While the Jayhawks’ defense gave up points last season, they have made strides and have some key returners in the secondary and up front. The biggest factor in Kansas' favor will be their ability to control the game with Daniels, who can make plays both through the air and on the ground. If Kansas can establish the run with Devin Neal and keep Fresno State's defense on its heels, it could open up opportunities for big plays in the passing game. However, the Jayhawks’ defense must rise to the occasion if they are to slow down Fresno State’s balanced attack.

The best bet for this game is Kansas first half spread -7. The Jayhawks’ offense is built to come out fast and score early, and with Daniels leading the charge, Kansas should be able to get off to a strong start. Fresno State might take a little longer to settle in, especially with their new quarterback adjusting to the offense. Kansas has been one of the more explosive teams in the first half under head coach Lance Leipold, and their ability to move the ball quickly gives them an edge in the opening 30 minutes. If the Jayhawks can establish a fast tempo, they should cover the -7 first-half spread, setting the tone for the rest of the game.

Fresno State vs. Kansas Pick

  • Pick: Kansas First Half -7 (-115) Click here to get the best Kansas odds at DraftKings Sportsbook

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