Arizona State vs. Mississippi State Prediction, Betting Pick, Latest CFB Odds for Week 2 Non-Conference Matchup
The Arizona State Sun Devils will battle the Mississippi State Bulldogs on Saturday evening in Starkville. Can Sam Leavitt and the Sun Devils come away with a road victory as a touchdown favorite? Let's take a look at our Arizona State vs. Mississippi State prediction for Saturday, September 6th.
OC Staff - September 6, 2025, 12:15 PM EDT
4 Minute ReadArizona State vs. Mississippi State Prediction, Betting Pick, Latest CFB Odds for Week 2 Non-Conference Matchup
A nonconference showdown brings plenty of intrigue tonight as Arizona State visits Mississippi State in Starkville. The Sun Devils enter the year inside the top 12, coming off a 2024 campaign that saw them make the expanded College Football Playoff. With momentum on their side, they now turn to quarterback Sam Leavitt, who takes the reins of the offense after transferring in last season and showing flashes of big-play ability. Arizona State will have to adjust to life without Cam Skattebo, their do-it-all back drafted into the NFL, but the roster remains talented and deep enough to contend nationally.
Mississippi State is looking for a bounce-back season after inconsistency plagued them a year ago. The Bulldogs still have SEC-level size and physicality in the trenches, and Davis Wade Stadium has a long history of tripping up nonconference opponents. Their ability to generate pressure and grind out drives makes them a dangerous foe for anyone, particularly against a team still working to find its offensive rhythm without its former star running back.
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Arizona State vs. Mississippi State Odds
Arizona State vs. Mississippi State Date, Time, and Where to Watch
- Date: Saturday, September 6, 2025
- Time: 7:30 PM ET
- Where to Watch: ESPN2
Click here for complete Arizona State vs. Mississippi State odds
Arizona State vs. Mississippi State Prediction
The key lies with Leavitt, who has already shown the ability to extend plays and keep defenses off balance. His dual-threat skill set gives Arizona State a new identity compared to last season, where Skattebo was the focal point. Against Mississippi State’s front seven, Leavitt’s mobility could be the X-factor, helping the Sun Devils stay out of obvious passing downs and forcing the Bulldogs to defend the entire field. If he can get into a rhythm early, Arizona State’s playmakers have the speed to create mismatches on the perimeter.
Arizona State’s defense also deserves more attention. This unit was a big reason for their playoff push in 2024, and many of those pieces are back. They play fast, tackle well in space, and excel at forcing turnovers. Mississippi State’s offense has talent, but it hasn’t consistently proven it can handle top-15 defenses without falling into lulls. If the Sun Devils can win first down and limit explosive plays, they’ll force the Bulldogs into longer drives, which plays right into ASU’s hands.
Mississippi State’s clearest path is to win at the line of scrimmage and make Leavitt uncomfortable. If they can collapse the pocket and bottle up the run, Arizona State will need to prove it can string together sustained drives without Skattebo’s reliability. But the Sun Devils have the kind of offensive versatility that can wear down defenses, mixing tempo with creative quarterback-designed runs and quick passing concepts. Over four quarters, that balance could separate the two teams.
Even on the road in SEC territory, Arizona State has the higher ceiling and the more dynamic quarterback. Mississippi State will compete, but the Sun Devils’ defensive speed and Leavitt’s upside give them the tools to control the game. If ASU limits mistakes, this is the type of matchup that validates their top-12 ranking.
Arizona State vs. Mississippi State Pick
- Pick: Arizona State -6.5 (-110) Click here to get the best odds at DraftKings Sportsbook
The Sun Devils’ quarterback advantage and roster depth make them the stronger side, with Leavitt poised to deliver a statement win in Starkville.
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