Tulane vs. Ole Miss Prediction, Betting Pick, Latest CFB Odds for Week 4
The Ole Miss Rebels will attempt to stay perfect when hosting the surging Tulane Green Wave on Saturday afternoon. Can Jake Retzlaff and Tulane put up a fight against the SEC powerhouse, or will they be overwhelmed by Lane Kiffin's Rebels? Let's take a look at this Tulane vs. Ole Miss prediction and best betting pick for Week 4 on Saturday, September 20th.
OC Staff - September 20, 2025, 10:15 AM EDT
5 Minute ReadTulane vs. Ole Miss Prediction: Can Jake Retzlaff, Green Wave Stun Rebels?
A battle of unbeatens is set for Oxford this weekend as the Tulane Green Wave visit the Ole Miss Rebels in a non-conference clash with plenty of intrigue. Both teams are off to 3-0 starts, but the paths they’ve taken and the circumstances heading into this matchup make for a fascinating storyline.
For Tulane, the spark has come from transfer quarterback Jake Retzlaff, who arrived from BYU and immediately energized the Green Wave offense. Retzlaff has guided Tulane to impressive early-season wins, including victories over Northwestern and Duke, showing poise in big moments and quickly becoming a leader in his new program. The Green Wave now face their biggest test yet, traveling into SEC country to prove they belong on the national stage.
Ole Miss, meanwhile, has kept rolling despite adversity under center. With starting quarterback Austin Simmons sidelined, backup Trinidad Chambliss has stepped in and kept the offense afloat, most recently leading the Rebels to a high-scoring win over Arkansas. Still, the injury situation looms large as Ole Miss looks to avoid a letdown as 12.5-point home favorites. With the Green Wave surging and the Rebels short-handed, Saturday’s showdown could be trickier than the oddsmakers suggest.
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Tulane vs. Ole Miss Odds
Tulane vs. Ole Miss Date, Time, and Where to Watch
- Date: Saturday, September 20, 2025
- Time: 3:30 PM ET
- Where to Watch: ESPN
Click here for complete Tulane vs. Ole Miss odds
Tulane vs. Ole Miss Prediction
Ole Miss has shown no signs of slowing down offensively, even with backup quarterback Trinidad Chambliss stepping in for injured starter Austin Simmons. The Rebels rank inside the top 10 nationally in passing offense and sit top 15 in scoring at 44 points per game, an explosive pace that has kept them unbeaten through three weeks. Chambliss has done enough to keep the machine rolling, leaning on a deep group of playmakers to spread the field and attack in waves.
Tulane, meanwhile, brings a very different offensive identity. The Green Wave’s ground game has been a strength, averaging 222 rushing yards per contest thanks to strong line play and a deep backfield. That rushing attack has powered their 3-0 start, but the overall production still lags behind Ole Miss. Tulane is averaging under 30 points per game, raising questions about whether they can keep pace if this turns into the kind of shootout the Rebels often create.
The betting market has reflected those doubts. After dipping as low as Tulane +10.5 earlier in the week, the spread has swung back to Ole Miss -12.5 with heavy support for the home side. Bettors and oddsmakers alike appear skeptical of Jake Retzlaff’s ability to engineer enough offense on the road against an SEC-caliber defense while simultaneously keeping up with an elite Rebel attack.
Our OddsChecker AI projections back up that skepticism, projecting Ole Miss closer to a -15 favorite. That points to value on the Rebels to cover, especially if their passing game continues firing at its current clip. With a talent edge across the board and one of the most dynamic offenses in the country, Ole Miss looks built to separate and win this one by at least two touchdowns.
Tulane vs. Ole Miss Pick
- Pick: Ole Miss -12.5 (-110) Click here to get the best odds at DraftKings Sportsbook
MClick here to get the best odds at FanDuel Sportsboore College Football Odds
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