Indiana vs. Michigan Prediction, Betting Pick, Latest CFB Odds for Saturday, October 24th
The Indiana Hoosiers travel to Ann Arbor looking to rebound from their first loss of the season against a Michigan Wolverines team coming off a gritty home victory over Penn State. Can Michigan’s rushing attack and defense shorten the game enough to stay within one possession against Josh Hoover and the defending national champions? Check out this Indiana vs. Michigan prediction and best bet for Saturday, October 24.
Peter Alexis - October 24, 2026, 11:00 AM EDT
5 Minute ReadIndiana vs. Michigan Prediction: Can Tommy Carr, Wolverines Stun Hoosiers on Saturday Afternoon?
No. 6 Indiana visits Michigan Stadium for a noon ET Big Ten matchup on FOX. The Hoosiers enter 6-1 and 3-1 in conference play after a narrow loss to Ohio State, while Michigan sits 4-2 and 1-2 after beating Penn State 21-18.
Indiana is favored by 7.5 points with an extremely low total of 42.5. That combination immediately makes the home underdog interesting because Michigan can lose by a full touchdown and still cover.
Indiana vs. Michigan Recent Results
Indiana Hoosiers (6-1), (3-1 Big Ten)
Indiana’s long winning streak ended with a 19-15 home loss to Ohio State. The Hoosiers still outgained the Buckeyes 369-313 and had an opportunity to take the lead late before falling just short.
Josh Hoover threw for 296 yards, while Charlie Becker produced 165 receiving yards. Indiana struggled more on the ground, finishing with only 73 rushing yards against one of the best defensive fronts in college football.
The performance still showed why Indiana remains a legitimate national contender. The Hoosiers stayed within one possession against another top opponent despite struggling to finish several important drives.
Ball security and quarterback efficiency remain major strengths. Hoover has generally avoided the mistakes that turn close games into comfortable losses, and Indiana has enough receiving talent to challenge Michigan vertically if the Wolverines become overly aggressive against the run.
Michigan Wolverines (4-2), (1-2 Big Ten)
Michigan returned to the win column with a 21-18 victory over Penn State. The Wolverines trailed 3-0 at halftime before scoring 21 second-half points and surviving a late Nittany Lions comeback attempt.
The rushing attack drove the turnaround. Michigan finished with 211 rushing yards, including explosive runs from Bryson Kuzdzal, Savion Hiter and Tommy Carr.
The passing game remained extremely limited with only 90 yards, but Michigan did not need significant passing production once the ground game began creating explosive plays.
The Wolverines are expected to lean more heavily on Carr at quarterback, giving the offense another rushing element against an Indiana defense that just held Ohio State to only 78 yards on the ground.
Indiana vs. Michigan Head to Head
Michigan has dominated the overall series, particularly in Ann Arbor, but Indiana won the most recent meeting.
- November 9, 2024: Indiana 20, Michigan 15
- October 14, 2023: Michigan 52, Indiana 7
- October 8, 2022: Michigan 31, Indiana 10
- November 6, 2021: Michigan 29, Indiana 7
- November 7, 2020: Indiana 38, Michigan 21
Michigan owns a 36-7 home record against Indiana and has won 22 consecutive meetings against the Hoosiers in Ann Arbor.
Indiana has not won at Michigan Stadium since 1967. The current Hoosiers are significantly stronger than most of the teams responsible for that history, but the venue remains one of the most difficult road assignments on their schedule.
Indiana vs. Michigan Date, Time, Where to Watch
- Date: Saturday, October 24th, 2026
- Time: 12:00 PM ET
- Location: Michigan Stadium, Ann Arbor, Michigan
- How to Watch: FOX
Indiana vs. Michigan Odds
- Spread: Indiana -7.5 (-104), Michigan +7.5 (-110)
- Total Points: Over 42.5 (-110), Under 42.5 (-105)
- Moneyline: Indiana (-295), Michigan (+250)
Click here for the latest Indiana vs. Michigan Odds
Indiana vs. Michigan Line Movement and Betting Splits
Indiana opened around a 7.5-point favorite and has remained between seven and 7.5 across the broader market. That half-point becomes extremely important in a game with a total barely above 40.
DraftKings bettors are leaning toward Indiana by ticket count, with roughly 57% of spread wagers on the favorite. The money tells the opposite story, with approximately 60% of the spread handle backing Michigan +7.5.
That means the average Michigan wager is considerably larger than the average Indiana wager. The moneyline remains overwhelmingly tilted toward Indiana, while the Over has attracted the vast majority of total action.
Indiana Hoosiers Injury Report and Team News
No Indiana players appear on the final official availability report.
That is an important advantage for a team coming off an extremely physical game against Ohio State. Indiana enters Ann Arbor without a designated injury absence or game-time decision on the final report.
The clean availability report gives Hoover his normal collection of skill-position options and keeps the offensive line intact against a Michigan defense that will attempt to turn this into a low-possession, field-position game.
Michigan Wolverines Injury Report and Team News
- Kendrick Bell (WR): Out, Undisclosed
- Dom Nichols (EDGE): Out, Undisclosed
- Mason Bonner (TE): Out, Undisclosed
- Braydon Alford (WR): Out, Undisclosed
- Micah Ka’apana (RB): Out, Undisclosed
- Julius Holly (DE): Out, Undisclosed
- Ace Hamilton (OL): Out, Undisclosed
- Andrew Sprague (OL): Out, Undisclosed
- Blake Frazier (OL): Out, Undisclosed
- Zack Marshall (TE): Out, Undisclosed
- Rod Moore (S): Game-Time Decision, Undisclosed
- Enow Etta (DT): Game-Time Decision, Undisclosed
The offensive-line injuries are the biggest concern for the Michigan side. Sprague and Frazier are both unavailable, while Hamilton further reduces the depth of a unit that must establish the run for Michigan’s offensive approach to work.
Nichols and Holly being out also thin the edge-rushing rotation. That could give Hoover additional time against a defense that cannot afford to let Indiana consistently attack from clean pockets.
Moore is one of the most important game-time decisions. Michigan needs as much experience as possible in the secondary against Indiana’s receiving group, particularly after Becker’s 165-yard performance against Ohio State.
The encouraging development is that several players who carried questionable or probable designations earlier in the week were cleared from the final report. Michigan still enters depleted, but the offensive line retains enough healthy pieces to attempt the run-heavy approach that worked against Penn State.
Indiana vs. Michigan Prediction
The number is the starting point. Indiana is clearly the better team through seven weeks, but laying 7.5 on the road in a game carrying a total of only 42.5 creates a difficult margin requirement.
Michigan does not need to score 30 points to cover. A 20-14, 23-17 or 24-17 Indiana victory all leaves the Wolverines inside the number. That creates significant value if Michigan can control tempo and keep the possession count low.
The Wolverines finally found something offensively against Penn State by leaning into the running game. Michigan rushed for 211 yards and generated several explosive runs after halftime, allowing the offense to function without needing consistent downfield passing.
Indiana’s run defense is considerably better than Penn State’s, so repeating that production will be difficult. The Hoosiers just held Ohio State to 78 rushing yards and will likely force Michigan to prove it can complete throws against loaded boxes.
Carr’s mobility still gives Michigan an additional way to manufacture yards. Quarterback movement, rollouts and designed runs can help protect a depleted offensive line while shortening the game through extended drives.
The Big House also matters. Indiana is trying to win in Ann Arbor for the first time since 1967, while Michigan has won 22 consecutive home meetings against the Hoosiers. Historical trends alone do not decide the wager, but the venue creates additional difficulty for a favorite being asked to win by more than a touchdown.
Indiana should have success through the air. Hoover threw for 296 yards against Ohio State, and Michigan is missing Nichols while Moore’s availability remains uncertain. Becker and the rest of the receiving group can create enough production to give the Hoosiers the outright edge.
The spread is a different question. Michigan has enough defense, rushing production and home-field advantage to turn this into another ugly Big Ten game where Indiana has to earn every possession.
The betting splits reinforce that position. More individual wagers are backing Indiana, but the larger share of spread money is sitting on Michigan +7.5.
Indiana vs. Michigan Best Bet
- Best Bet: Michigan +7.5 (-110) Check out these best odds at DraftKings Sportsbook
Indiana is the stronger team and should be favored, but the combination of a 42.5 total and more than a touchdown of spread protection creates value on Michigan.
The Wolverines can shorten the game through the run, have already shown they can win defensive battles at home and do not need to threaten the outright upset for this wager to cash. Getting the hook above seven is enough to back Michigan in Ann Arbor.
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