Oregon vs. Ohio State Prediction, Betting Pick, Latest CFB Odds for Saturday, November 7th

Oregon vs. Ohio State Prediction: Can Ryan Day's Buckeyes Bounce Back Despite Backup QB?

Oregon (5-3, 3-2 Big Ten) visits No. 11 Ohio State (6-2, 4-1 Big Ten) at Ohio Stadium on Saturday, November 7, with kickoff scheduled for 3:30 PM ET on CBS. The Ducks enter following a 34-26 victory over No. 20 Northwestern, while the Buckeyes suffered a disappointing 30-18 road defeat against USC.

Both programs entered the season among the national championship favorites but have struggled with offensive consistency since losing their starting quarterbacks. Ohio State returns home as a substantial favorite behind one of the nation's strongest defenses, while Oregon hopes to build on an improved performance from Raiola and its recently adjusted offensive coaching staff.

Oregon vs. Ohio State Recent Results

Oregon Ducks (5-3), (3-2 Big Ten)

Oregon returned to the win column with an impressive 34-26 comeback victory over No. 20 Northwestern last Saturday. The Ducks trailed 20-6 late in the first half before scoring 28 of the game's final 34 points, demonstrating improved offensive execution under new play-caller Jay Johnson.

Quarterback Dylan Raiola completed 22 of 31 passes for 336 yards and three touchdowns without an interception. Receiver Dakorien Moore caught seven passes for 128 yards and two touchdowns, including a 75-yard fourth-quarter reception that extended Oregon's advantage to eight points.

Freshman running back Brandon Smith also delivered an important performance, rushing for 82 yards and a touchdown on just eight carries. The Ducks generated 441 total yards and averaged 8.5 yards per play after halftime, overcoming an early offensive slump.

Oregon's defense also improved considerably during the second half, allowing just six points and 172 total yards over the final two quarters. The Ducks recorded three sacks and held Northwestern to just one conversion on eight second-half third-down attempts.

Oregon previously suffered a 21-10 defeat against Illinois on October 24, failing to score after building an early 10-point advantage. The Ducks also defeated Nebraska 17-14 and lost to UCLA 17-15 earlier in October, highlighting their difficulties generating consistent offense after losing Dante Moore.

Oregon enters Saturday averaging 33.3 points and 425.4 total yards per game, including 285.3 passing yards. The defense allows 21.4 points and 341.8 yards per contest, while its secondary has generated 49 passes defended, ranking among the nation's leaders.

Ohio State Buckeyes (6-2), (4-1 Big Ten)

Ohio State suffered its second defeat with a 30-18 road loss against USC last Saturday. The Buckeyes generated 464 total yards and 25 first downs compared with 338 yards and 15 first downs for the Trojans, but their inability to finish scoring opportunities prevented them from capitalizing on those advantages.

Freshman quarterback Luke Fahey completed 21 of 38 passes for 260 yards and a touchdown in his first collegiate start. Running backs Bo Jackson and Isaiah West combined for 193 rushing yards on 34 carries, while Jeremiah Smith caught 10 passes for 83 yards and a touchdown.

The Buckeyes controlled possession for more than 39 minutes but settled for four field goals before scoring their only touchdown late in the fourth quarter. Ohio State also struggled with offensive-line protection, allowing significant pressure against an aggressive USC defensive front.

Defensively, the Buckeyes recorded nine tackles for loss but allowed several explosive plays, including a 69-yard touchdown reception by Trent Mosley. Ohio State struggled with tackling and communication, allowing USC to build a 27-9 advantage before the Buckeyes attempted a late comeback.

Ohio State previously defeated No. 4 Indiana 19-15 on October 17, relying on a strong defensive performance despite losing starting quarterback Julian Sayin. The Buckeyes also defeated Maryland 45-16 and Iowa 31-14 earlier in October, demonstrating their ability to generate substantial offense against quality Big Ten opponents.

Ohio State enters Saturday averaging 36.6 points and 474.8 total yards per game, including 315.3 passing yards. The defense allows just 15.5 points and 273.5 total yards per contest, including only 95.8 rushing yards, maintaining one of the strongest statistical profiles in the Big Ten.

Oregon vs. Ohio State Head to Head

Ohio State leads the all-time series 10-2, although Oregon has won two of the last three meetings.

• January 1, 2025: Ohio State 41, Oregon 21 (College Football Playoff)
• October 12, 2024: Oregon 32, Ohio State 31
• September 11, 2021: Oregon 35, Ohio State 28
• January 12, 2015: Ohio State 42, Oregon 20 (National Championship)
• January 1, 2010: Ohio State 26, Oregon 17 (Rose Bowl)

Ohio State dominated the most recent meeting, defeating Oregon 41-21 in the 2025 Rose Bowl before continuing its run to the national championship. The Buckeyes established a 34-0 first-half advantage and consistently disrupted Oregon's passing attack, finishing with eight sacks and 13 tackles for loss.

However, the Ducks won their previous two meetings, including a dramatic 32-31 victory in Eugene during the 2024 regular season and a 35-28 upset in Columbus in 2021.

Saturday marks Oregon's first trip to Ohio Stadium since that 2021 victory. Both programs have undergone significant personnel changes, particularly at quarterback, making their current offensive execution and defensive matchups considerably more important than the historical results.

Oregon vs. Ohio State Date, Time, Where to Watch

• Date: Saturday, November 7th, 2026
• Time: 3:30 PM ET
• Location: Ohio Stadium, Columbus, Ohio
• How to Watch: CBS

Oregon vs. Ohio State Odds

• Spread: Oregon +7.5 (-105), Ohio State -7.5 (-105)
• Total Points: Over 46 (+100), Under 46 (-110)
• Moneyline: Oregon (+245), Ohio State (-275)

Click here for the latest Oregon vs. Ohio State Odds

Oregon vs. Ohio State Line Movement and Betting Splits

Ohio State opened as approximately a 9.5-point favorite before the market moved toward Oregon. The supplied sportsbook currently lists the Buckeyes at -7.5, representing two points of movement toward the Ducks following Ohio State's defeat against USC and Oregon's victory over Northwestern.

The total has remained relatively stable around 46 points, reflecting the offensive adjustments both programs have experienced following injuries to their starting quarterbacks. Ohio State's defensive efficiency has also contributed to lower scoring expectations, particularly with Oregon struggling to consistently establish its rushing attack.

Ohio State enters with a 5-3 record against the spread, while Oregon has covered three of its first eight games. Reliable ticket and handle percentages have not established a consistent directional advantage, but the availability of Ohio State -7 provides a meaningful improvement over -7.5 by offering push protection against an exact touchdown victory.

Oregon Ducks Injury Report and Team News

• Aaron Flowers (DB): Out, Undisclosed
• Andrew Olesh (TE): Out, Undisclosed
• Brayden Platt (LB): Out, Undisclosed
• Dante Moore (QB): Out, Concussion
• Dave Iuli (OL): Out, Undisclosed
• Jordon Davison (RB): Out, Undisclosed
• Matthew Johnson (DL): Out, Undisclosed
• Messiah Hampton (WR): Out, Undisclosed
• Trent Ferguson (OL): Out, Undisclosed
• Jeremiah McClellan (WR): Probable, Foot

Oregon's biggest concern remains the absence of Moore, whose season-ending injury has forced Raiola into the starting role. The Ducks will also be without leading rusher Davison, creating additional pressure on Dierre Hill Jr. and Smith to maintain offensive balance. Smith demonstrated encouraging explosiveness against Northwestern, but Ohio State's defensive front presents a substantially more difficult matchup.

The Ducks face additional injuries along the offensive line, with Iuli and Ferguson unavailable. Those losses could become particularly important against an Ohio State defense allowing fewer than 96 rushing yards per game, especially with Oregon attempting to protect Raiola against a physical defensive front.

Defensively, Oregon will be without Platt, Flowers and Johnson, reducing depth across multiple position groups. However, the pass-rushing combination of Matayo Uiagalelei and Teitum Tuioti remains one of the Big Ten's strongest, with the duo accounting for 11.5 sacks this season. Their ability to pressure Fahey will be critical to Oregon's chances of remaining competitive.

Ohio State Buckeyes Injury Report and Team News

• Deshawn Stewart (S): Out, Undisclosed
• Jaxon Powell (OL): Out, Undisclosed
• Ja'Kobi Jackson (RB): Out, Foot
• Julian Sayin (QB): Out, Arm
• Maxence LeBlanc (TE): Out, Undisclosed
• Brandon Inniss (WR): Questionable, Undisclosed
• Brock Boyd (WR): Questionable, Undisclosed
• Eli Lee (LB): Questionable, Undisclosed
• Ian Moore (OL): Questionable, Undisclosed

Ohio State continues operating without Sayin, who suffered a significant throwing-arm injury against Indiana. Fahey will make his second consecutive start after throwing for 260 yards against USC, while the absence of Ja'Kobi Jackson places additional responsibility on Bo Jackson and West in the backfield.

The Buckeyes also face uncertainty at left tackle, with Moore questionable after leaving the USC matchup. Austin Siereveld could move into the starting role if Moore is unavailable, creating another potential adjustment against Oregon's disruptive defensive line. Inniss and Boyd also remain questionable, potentially limiting receiving depth behind Smith.

Defensively, Ohio State could receive an important boost from the anticipated return of nickelback Jay Timmons, who has missed three of the last four games. Defensive tackle Eddrick Houston is also expected to be available despite suffering an injury against USC, providing additional stability for a unit attempting to rebound from an inconsistent performance.

Oregon vs. Ohio State Prediction

Ohio State enters as the deserved home favorite, and several important matchup factors support the Buckeyes' ability to rebound with a victory by more than a touchdown against an Oregon team struggling with offensive consistency and significant personnel losses.

The most significant advantage comes from Ohio State's rushing defense. The Buckeyes allow just 95.8 rushing yards per game, ranking among the nation's strongest units, while Oregon averages 140.1. That creates a difficult matchup for an Oregon offense already dealing with the loss of Davison and significant injuries along its offensive line.

The absence of Davison is particularly important because Oregon has relied on its rushing attack to establish offensive balance and limit the pressure on Raiola. Smith provided an explosive performance against Northwestern, averaging more than 10 yards per carry, but Ohio State possesses a considerably more physical defensive front. Preventing Oregon from consistently generating early-down rushing production would force Raiola into difficult passing situations against a talented secondary.

Raiola's improvement against Northwestern deserves respect, particularly after throwing for 336 yards and three touchdowns while helping Oregon erase a 14-point deficit. However, the Buckeyes allow just 177.8 passing yards per game, creating a substantially more difficult matchup than the one Oregon encountered last weekend. Ohio State also benefits from the potential return of Timmons, whose coverage and tackling ability could help limit the Ducks' explosive receiving threats.

Oregon's passing attack presents challenges through Dakorien Moore and Evan Stewart. Moore has accumulated 545 receiving yards and six touchdowns, while Stewart provides another experienced downfield threat. However, Ohio State should be capable of generating pressure through its defensive front, particularly with Oregon operating without multiple offensive linemen. If the Buckeyes consistently disrupt Raiola's pocket, the Ducks could struggle to replicate their recent passing efficiency.

Ohio State's offense also possesses considerable opportunities despite Fahey's inexperience. The Buckeyes generated 464 yards and 25 first downs against USC, demonstrating their ability to move the football against a talented opponent. Their biggest problem was converting those possessions into touchdowns, particularly after reaching scoring territory. Improved red-zone execution could substantially increase Ohio State's scoring production without requiring a major change in offensive approach.

Bo Jackson provides another important matchup advantage. The Ohio State running back rushed for 121 yards against USC, while West added productive complementary rushing contributions. Oregon allows 133.8 rushing yards per game, creating opportunities for the Buckeyes to establish control on the ground and reduce the burden on Fahey. Ohio State's ability to generate more than 200 rushing yards against USC also suggests the offensive line can create production despite its protection difficulties.

Smith remains the most dangerous individual offensive weapon in the matchup. The Ohio State receiver has accumulated nearly 1,000 receiving yards and continues generating explosive plays despite the team's quarterback change. His ability to create separation, win contested catches and produce near the goal line provides Fahey with a dependable target against an Oregon secondary allowing 208 passing yards per game.

The biggest concern for Ohio State is Oregon's pass rush. Uiagalelei and Tuioti have combined for 11.5 sacks, while the Ducks have demonstrated the ability to generate pressure without consistently committing additional defenders. Ohio State allowed 21 quarterback pressures against USC, creating significant challenges for Fahey. If Oregon reproduces that disruption, the Buckeyes could struggle to establish the offensive efficiency necessary to cover a full touchdown.

However, Ohio State benefits from returning to Columbus after a difficult road defeat. The Buckeyes have won 12 consecutive games at Ohio Stadium and remain undefeated at home this season. Oregon has struggled offensively in several road matchups, including its 21-10 defeat against Illinois, while Ohio State should benefit from a more familiar environment for Fahey's second collegiate start.

The possession matchup also supports Ohio State's ability to establish control. The Buckeyes average more than 33 minutes of possession per game, compared with Oregon's approximately 28 minutes. Ohio State should have opportunities to sustain drives through Jackson and West, reduce Oregon's offensive possessions and gradually create separation if its defense prevents explosive passing plays.

Oregon has demonstrated the ability to challenge elite opponents, including defeating Ohio State during its previous trip to Columbus. However, the Ducks' current offensive personnel situation is considerably different, with Moore and Davison unavailable and multiple offensive-line injuries affecting their ability to establish balance. Ohio State possesses the defensive front and offensive playmakers required to capitalize on those limitations.

The decisive factor could be red-zone execution. Ohio State struggled to finish drives against USC, but Oregon's defense is more vulnerable against the run and has allowed more than 21 points per game. If the Buckeyes convert a greater share of their scoring opportunities into touchdowns, while their defense forces Raiola into long-yardage situations, a victory by multiple possessions becomes realistic.

Oregon vs. Ohio State Best Bet

• Best Bet: Ohio State -7 (-120) Check out these best odds at DraftKings Sportsbook

Ohio State enters with one of the nation's strongest defenses and a favorable matchup against an Oregon offense dealing with significant quarterback, running back and offensive-line injuries. The Buckeyes allow fewer than 96 rushing yards per game, creating opportunities to force Raiola into predictable passing situations while limiting the Ducks' ability to sustain drives.

Oregon possesses enough passing talent and defensive pressure to remain competitive, but Ohio State should benefit from returning home after its defeat against USC. Jackson provides a dependable rushing option, while Smith gives Fahey an explosive receiving threat capable of changing the game through individual plays. Getting the Buckeyes at -7 rather than -7.5 provides valuable push protection against an exact touchdown victory, making Ohio State an attractive home favorite in this important Big Ten matchup.

More College Football Odds

• Click here for complete College Football Odds
• Looking for more CFB picks, check out the best picks from our OC Staff
• Can Ohio State Bounce Back in 2026? The Buckeyes are National Title Favorites Once Again