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The OddsChecker staff brings you their best bets for Week 16's Thursday Night Football matchup between the San Francisco 49ers and Tennessee Titans. Don't miss out on the plays they like the most this Thursday.

Thursday Night Football Predictions Week 16: Our Staff's Best Bets for San Francisco 49ers vs. Tennessee Titans

Primetime football is back and we've got a great matchup on our hands for this Week 16 Thursday Night Football game. The Tennessee Titans and San Francisco 49ers meet in Nashville, Tennessee.

So, in preparation for this one, we got our staff together so they could give us their favorite bets for this showdown between potential playoff teams.

Click here for the latest 49ers vs. Titans odds

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San Francisco 49ers vs. Tennessee Titans Picks

Titans +3 (-105)

Love the dog at home tonight as they return starting wideout AJ Brown to the lineup, which will be a huge boost for their offense. I think this is a great fade-the-public play, taking the dog at home who has a chance to clinch their division this week. Give me the Titans with the points & sprinkle that money line!!

-- Matt McCuen (@DeadPresPicks)

Deebo Samuel Anytime Touchdown (+115)

Samuel has become a force in the running game for the Niners. During their five-game winning streak, Samuel has seven touchdowns between five rushing touchdowns and two receiving touchdowns. He's getting around 5-8 carries per game and carries that are usually around the goal line. At the end of the day, he's one of two of the Niners' biggest playmakers and they'll want to get him the ball around the endzone. He could also break loose for a long rushing touchdown too!

-- Jason Radowitz (@Jason_Radowitz)

Okay, let's think for a minute. In 13 games played, Deebo has 12 touchdowns on the season, meaning he finds himself in the endzone in 92 percent of the time this year. Hold on it gets better, over the last five games he has seven touchdowns and you're telling me I can get plus money on him scoring tonight? Christmas came early my friends. The value here is too good to pass up so while it might not be some out of the box kind of play tonight, it's likely a safe bet all things considered.

-- Matt O'Leary (@MattOLearyNY)

49ers -3 (-110)

I don't think a team is better prepared to have to play on a short week than the 49ers. I think the simplicity of Kyle Shanahan's offense (I say that as a compliment) gives San Francisco an advantage for this quick turnaround contest. Factor in all the injury concerns for Tennessee, but more importantly the fact that they feel lost on offense. Look at these recent point totals. 13 vs Pittsburgh, 20 vs Jags, 13 vs Pats, and 13 vs Texans. They haven't scored more than 20 points in the last month.

-- Geoff Fienberg (@gfienberg17)

George Kittle Under 70.5 Receiving Yards (+105)

There's no doubt that Goerge Kittle has been unstoppable the last 3 weeks (181, 151, and 93 receiving yards). In the 3 games prior, Kittle was held to 50 or fewer yards. So yes, it is possible for Kittle to have under 70.5 receiving yards. His opponent, the Tennessee Titans have not allowed a tight end to go over 65 yards this season. The closest came in Week 7 when Travis Kelce had 65 receiving yards. The Titans haven't even allowed a tight end to surpass 51 yards since the Travis Kelce performance. It may feel like a crazy bet, but that's why we call it gambling! The Titans aren't about to let their first tight end go over 70 yards tonight. I believe they are able to contain Kittle just enough to make this a safe bet. Plus, I'm loving the money line with this one.

-- Nate Hamilton (@DomiNateFF)

D’Onta Foreman o29.5 Rush Yds + Brandon Aiyuk o34.5 Rec Yds (-115 SGP)

We’ve got a Same-Game Parlay for Thursday Night Football!

D’Onta Foreman has taken over as the lead back in this Tennessee backfield for a team that is committed to running the ball. The Titans drew up 37 run plays and only 32 passing plays in last week’s loss to the Steelers. Ryan Tannehill has struggled, and handing off to Foreman has been their most efficient way of moving the ball. He’s averaging 18 carries and 88 rushing yards per game over his last three games, easily clearing the 30-yard mark in all three. The Niners' run D is a tough matchup but Foreman will probably see around 12-15 carries tonight, so he may even hit this in the first half.

Brandon Aiyuk has emerged as the San Francisco WR1 (kind of). With Deebo Samuel taking plenty of snaps at running back on a weekly basis, Aiyuk has played over 92% of the Niners’ offensive snaps in their last eight games. He has also hit the 35-yard mark in 7 of 8 games during this stretch, averaging 61.1 YPG. The Titans have allowed the most targets, most receptions, and 2nd most yards to opposing wideouts in 2021. This positive matchup certainly works in Aiyuk’s favor, and he doesn’t even need to catch a ton of passes to hit this number.

Good luck if you’re riding with this SGP and let’s enjoy some the last Thursday Night game of the year!

-- Gray Gutfreund (@propbetguru)

Brandon Aiyuk Over 45.5 Receiving Yards (-110)

The Titans have allowed the most receptions and the second-most yards to opposing wide receivers this season. He's topped this number in five of the last seven weeks. Over that span, he's averaging 4.1 receptions and 63.4 yards. In the Titan's 14 games this season, they have allowed at least two wide receivers to top this number in 10 games! The Titans boast one of the NFL's best run defenses making me believe the 49ers will be forced to throw a bit more than usual. Over the last four weeks, they have allowed the fewest rushing yards per game and fewest yards per carry in the NFL. I love Aiyuk to have a solid game tonight against this Tennessee secondary. Best of luck if you tail!

-- Tom Viera (Tom_Viera)

Article Author


Brian is a sports journalist with close to ten years of experience in the business. A lifelong Philadelphia sports fan with a passion for all things sports gambling.

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