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Josh Allen & Devin Singletary Bills celebrate

Kansas City Chiefs vs. Buffalo Bills Prediction, Pick, Odds: Can Josh Allen and Bills Offense Go Off?

The Kansas City Chiefs host the Buffalo Bills this afternoon. Can Josh Allen and the Bills' offense go off? John Hyslop breaks it down.

Kansas City Chiefs vs. Buffalo Bills Prediction, Pick, Odds: Can Josh Allen and Bills Offense Go Off?

We need a banger for today. It's Sunday and I'm on a plane headed for Disney World right now. That's right, I'm legit on a plane, headed to Disney World, telling you about the Play of the Millennium. That's what I call dedication people. I actually don't even know what else you could call it. The thing is, today at 4:25 pm ET, we're going to watch the Buffalo Bills get it on with the Kansas City Chiefs. I don't need to tell you that we will need a play. Not just any play, but a big one. Lucky for us, after going through every possible way we could play this thing, I've found what many already know to be the greatest play of this millennium. It could be the greatest play of all time. We'll have to wait and see about that.

Chiefs vs. Bills Start Time, Where to Watch, and Odds

  • Date: October 16, 2022
  • Game Time: 4:25 pm ET
  • Where to Watch: CBS

Chiefs vs. Bills Odds

  • Spread: Bills -3 (-110), Chiefs +3 (-110)
  • Total Odds: O/U 54 (-110)
  • Moneyline Odds: Bills (-135), Chiefs (+130)

Click Here for Chiefs vs Bills Odds

Kansas City Chiefs vs. Buffalo Bills Pick

Buffalo Bills Team Total Over 28 Points (-108) (Bet $108 to win $100)

*Odds Available at FanDuel at Time of Publishing*

We're at FanDuel for this one since they have this number. Right now at DraftKings, we're looking at 28.5 (-105). I think they get that but at the end of the day, I'd way rather have 28 at -108 than 28.5 at -105. It just makes sense. You know it, I know it, the books know it. I wish I knew which way this thing would move, but I don't so betting it right now is probably a good idea.

Kansas City Chiefs vs. Buffalo Bills Prediction

This is probably the best game of the regular season. I'm serious. You can look through the rest of the season and I doubt you'll find anything better. It's that good. There's the number one seed in the AFC going on here. Maybe a little MVP stuff with Josh Allen and Patrick Mahomes, who knows? The thing that concerns me more than anything else though is the points that could be scored in this one.

I know most "over" games don't live up to the billing but I think this one does. It has all the makings of a points extravaganza. For starters, the Buffalo Bills appear to be out for blood this season. They've hung 30+ three different times already. The two times they didn't, weird stuff happened. They had the heat game in Miami and they had the game in Baltimore where the Ravens played keep away. I doubt anything like that happens tonight.

The Chiefs' do look good on defense but they are coming off two games where they looked sieve-like. We've seen them give up this number to both teams they've played in the last two weeks. In the other three games they've played, they've given up at least 20. Two of those games were against the Indianapolis Colts and Arizona Cardinals so they don't even count. I don't want to say it, but this game reminds me of the Los Angeles Rams vs. Kansas City Chiefs game a few years ago when both teams combined for 1000 points. Feels right.

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