Odds format
United States
Share to Facebook
Share to Twitter
Copy Link
The Kansas City Chiefs and San Francisco 49ers will look to bounce back after tough losses last week. But only one team will be able to. Jason Radowitz provides an answer on which team it will be.

San Francisco 49ers vs. Kansas City Chiefs Prediction, Pick, Odds: Will Patrick Mahomes, Chiefs Bounce Back?

The Kansas City Chiefs and San Francisco 49ers will look to bounce back after tough losses last week.

Only one team will.

That team will likely be the Chiefs, who are 4-2 on the season and looking like a real playoff contender. The Chiefs have averaged close to 400 yards of offense this season and look good enough on defense.

Meanwhile, the 49ers have only scored 20.3 points per game but have allowed just 14.8 points. The defense for San Francisco has been incredible through the first six games of the season.

Will the Chiefs' offense or the 49ers' defense show up on game day?

Here are our picks, predictions, and odds for Sunday's game between the San Francisco 49ers vs. Kansas City Chiefs.

49ers vs. Chiefs Start Time, Where to Watch, and Odds

  • Date: October 23, 2022
  • Game Time: 4:25 pm ET
  • Where to Watch: FOX

49ers vs. Chiefs Odds

  • Spread: 49ers +3 (-110), Chiefs -3 (-110)
  • Total Odds: O/U 48.5 (-110)
  • Moneyline Odds: 49ers (+145), Chiefs (-165)

Click Here for 49ers vs. Chiefs Odds

49ers vs. Chiefs Injury Report


Questionable: DL Nick Bosa (Groin), DL Ark Armstead (Foot), TE Tyler Kroft (Knee)

Out: OT Trent Williams (Ankle), DB Jimmie Ward (Hand)


Questionable: CB Trent McDuffie (Hamstring), S Bryan Cook (Concussion), CB Rashad Fenton (Hamstring)

San Francisco 49ers vs. Kansas City Chiefs Prediction

The Kansas City Chiefs have easily been the better offense. Patrick Mahomes has thrown 17 touchdowns with just four interceptions on the season. He's also thrown for 1736 yards in six games on the season.

His receivers are still very talented, between Travis Kelce, JuJu Smith Schuster, Marquez Valdes-Scantling, and Mecole Hardman. But the pass protection has been far from excellent for the Chiefs.

Kelce already has seven touchdowns on 41 receptions for 455 yards. The loss to Tyreek Hill hasn't hurt the Kansas City offense much.

Defensively, the Chiefs have struggled against the run and aren't tackling very well. The coverage also has been average at best, allowing 286 yards in the air per game.

After all, the Chiefs' defense is good enough when they have Patrick Mahomes at quarterback.

Bet $5, Win $200 Extra on your favorite NFL Moneyline now, with this HUGE DraftKings promo code!

On the other hand, the 49ers are averaging under 21 points per game. However, they've also held opponents to 14.8 yards per game.

Jimmy Garoppolo has taken over at quarterback and has thrown 1153 yards with seven touchdowns and three interceptions. The passing game has been a bit weak, but his receivers are dropping passes left and right lately.

The 49ers also love running the football, but the run block could be better.

Deebo Samuel has rushed plenty of times, but he's also been a massive factor in the passing game, earning 27 catches and 345 yards through six games.

The defense for the 49ers has been elite, especially in coverage, holding teams to 193.3 yards per game in the air. The pass rush has also been effective, and the 49ers continue to do a solid job at making tackles.

Don't be surprised if the 49ers keep this game close into the fourth quarter. However, the Chiefs should be able to find a way out of San Francisco with a win. Sometimes a good defense isn't good enough against Mahomes.

San Francisco 49ers vs. Kansas City Chiefs Pick

Looking for the best sportsbook offers? Check out the free bets page

Article Author


Jason grew up an avid sports fan. His passion for sports writing grew in high school and he developed a blog that was strictly for New York Sports. From his work, you will quickly realize that he loves looking at games from an analytical and numbers perspective and hopes to provide you with that same perspective in his articles.


Almost there!

We are loading your bets, and they will be here in a second.