Odds format
United States
Share to Facebook
Share to Twitter
Copy Link
The New Orleans Saints vs. the Arizona Cardinals will clash from Glendale, Arizona, for Thursday night football. Both teams enter play with a record of 2-4. Who's going to be 3-4 at the end of this game? Matt McCuen answers.

Arizona Cardinals vs. New Orleans Prediction, Pick Against the Spread, and Latest Odds

The New Orleans Saints vs. the Arizona Cardinals will clash from Glendale, Arizona, for Thursday night football. These teams both enter play having a disappointing team so far with a record of 2-4. Let's get into my prediction, pick, and odds for the Cardinals vs. Saints.

Cardinals vs. Saints Start Time, Where to Watch, and Odds

  • Date: October 20, 2022
  • Game Time: 8:15 pm ET
  • Where to Watch: Prime Video

Cardinals vs. Saints Odds

  • Spread: Cardinals -3 (+100), Saints -3 (-110)
  • Total Odds: Over 43.5 (-110), Under 43.5 (-105)
  • Moneyline Odds: Cardinals (-140), Saints (+125)

Click Here for Cardinals vs. Saints Odds

Arizona Cardinals vs. New Orleans Prediction

New Orleans came into the year with a new look team as Sean Payton retired, to the surprise of many in the off-season. Payton was the most successful coach in Saints history, and new head coach Dennis Allen will have a lot of pressure on him to continue the Saint's winning ways. New Orleans has had a lot of issues so far this season with injuries. Starting QB Jamies Winston has missed the last three games, which forced veteran gunslinger Andy Dalton into action.

Dalton will get the start tonight. It also appears that the Saints will be without two of their top wideouts, Michael Thomas and Jarvis Landry. You thought that was all? They will also be without star cornerback Marshon Latimore and starting guard Andrus Peat. The bottom line is that the Saints are pretty depleted at the moment, and they will need guys to step up if they want to pull off this win tonight.

Arizona, on the other side of things, will be returning their top playmaker in the form of Deandre Hopkins. Hopkins was suspended to start the year, but the return of number ten should be massive for the Cardinals. He has been his favorite option of Murray when on the field. Running back James Conner will also be back in action tonight. They will be without star wideout Holly Wood Brown, however. 

I love this spot for the Cardinals. New Orleans is dealing with a ton of injuries, and these are key players that they will be without. I think it is extremely difficult to overcome all of these injuries in a short week. The Cardinals are a team that j still believe is better than their 2-4 record indicates.

The addition of Hopkins on the field should be massive for Murray. I know Brown is out and that he was a huge part of this offense, but Murray and Hopkins have shown how dominant they can be together. I also believe that without Latimore tonight, they should be able to exploit that matchup all night. I trust that we will see this Cardinals offense finally get going and pull off the win at home tonight. 

Arizona Cardinals vs. New Orleans Saints Pick

Pick: Arizona Cardinals ML -140 (Bet $140 to collect $100)

Additional Thursday Night Football Picks

Tired of scouring the internet for the best sportsbook offers? Don't worry, we have you covered! Click here for all of the very best offers in your state

Error fetching data.

Article Author


Matt McCuen is a native of Delco, PA. He has been working in the sports gambling industry and creating content for the last few years. He is an expert in numerous different sports, including the NFL, NBA, MLB, NHL, and collegiate sports. You can follow Matt on Twitter at @DeadPresPicks.


Almost there!

We are loading your bets, and they will be here in a second.