San Francisco 49ers vs. Los Angeles Chargers Prediction, Pick, Odds: Will Deebo Samuel and 49ers Dominate SNF?

San Francisco 49ers vs. Los Angeles Chargers Prediction, Pick, Odds: Will Deebo Samuel and 49ers Dominate SNF?

49ers vs. Chargers Start Time and Where to Watch, and Odds

• Date: November 13, 2022
• Game Time: 8:20 pm ET
• Where to Watch: NBC

49ers vs. Chargers Odds

• Moneyline: 49ers (-315), Chargers (+275)
• Spread: 49ers -7.5 (-110), Chargers +7.5 (-110)
• Total: Over/Under 45.5 (-110)

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49ers vs. Chargers Prediction

San Francisco 49ers Team Total Over 27 (-110) (Bet $100 to Collect $190) Click here for the best odds, available at FanDuel

You could play this in a million different places, but I chose FanDuel. They've got two options which I think is very cool, with 26.5 (-126) and 27 (-110). Obviously, we're not soft, so we're going 27 (-110), but it's nice to know they cater to the weak as well. We all deserve lines to bet. It should be noted that if you do like the line made for the weak, DraftKings has 26.5 (-120), which is actually better than FanDuel. Just a thought.

By the time this bet kicks off, we'll be in need of a bet that has no chance of losing. It's been a long weekend with a ton of bets, and after a weekend like that, we all just need a banger that cashes easily. That's why I chose this one. As of the time of writing, there is no chance this thing could lose. In fact, I can't even believe there's a book on this planet that would allow us to bet the 49ers anywhere under 30. Seems reckless.

For starters, the 49ers are now a 30-burger team. With Deebo Samuel back and Christian McCaffrey fully assimilated, it doesn't matter that Jimmy Garoppolo is their quarterback. They are going to put up points. It's just how it is. But this one really isn't totally about the 49ers. This one is about the Los Angeles Chargers, who've given up more points per game this season than every team in the NFL except two. That's bad.

The issue with the Chargers is the fact that they give up yards on the ground like no other team in the NFL. Literally. They are the worst in the NFL in opponent yards per attempt this season. They give up 5.7 yards per attempt. Now they are tasked with stopping a Kyle Shannahan offense with McCaffrey and Samuel. Remember that Kyle Juszcyk will be back, too, so we can expect to see weird stuff with him. I can't imagine the 49ers scoring less than 30 points tonight. This could be the greatest bet of all time.