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Trey Lance 49ers

San Francisco 49ers vs. Los Angeles Chargers Predictions: How to Bet on Tonight's Preseason Game

The San Francisco 49ers and the Los Angeles Chargers play the late-night game on Friday's NFL Preseason Week 3 slate. JT Miller explains how he's betting on tonight's preseason game. Don't miss out on this NFL Preseason Week 3 pick.

San Francisco 49ers vs. Los Angeles Chargers Predictions: How to Bet on Tonight's Preseason Game

Well, this weekend, football season really starts to feel as if it is underway, with NFL preseason coming to a close and college football kicking off the festivities with week zero starting tomorrow. Although the guys in this league are well out of high school, they get a feeling tonight that they (and everyone else who has ever put pads on) love and chase in life; that feeling you get on Friday nights under those lights. Tonight, we have three NFL preseason games, and we are going to dive into the late-night matchup between the Los Angeles Chargers and the San Francisco 49ers.

49ers vs. Chargers Date, Time, and Where to Watch

  • Date: August 25, 2023
  • Time: 10:00 pm ET
  • Where to Watch: NFL Network

San Francisco 49ers vs. Los Angeles Chargers Prediction

These are two of football's best teams, and both have high expectations going into the season. San Francisco is coming off a trip to the National Football Conference championship game in which they lost to the Philadelphia Eagles, but the trip was more impressive than you think. The Niners are one of the deepest and most well-rounded teams on both sides of the ball, but they fell to the third and fourth-string QBs by that point.

The good news for us is that means the quarterback room is loaded, and everyone getting reps tonight can effectively move the ball in this wondered offensive scheme.

On the flip side, the Chargers have so many weapons offensively, and assuming the first-stringers get snaps tonight, this first quarter could get off to a hot start. I think there is a lot of opportunity for this game to turn into a high-scoring affair with two great coaches and a lot of talented signal callers getting time in this one against predominately not tier-one defensive units. Each game of the preseason has gone over for these squads so far.

San Francisco 49ers vs. Los Angeles Chargers Pick

LAC/SFG o38 -110 is currently the best odds. Click here to see which sportsbook has the best odds for this pick

NFL Preseason Odds

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