DraftKings Pick 6 Thursday Night Football: Four DK Pick 6 Picks for Rams vs. 49ers

DraftKings Pick 6 Thursday Night Football: Four DK Pick 6 Picks for Rams vs. 49ers

The Los Angeles Rams will take on the San Francisco 49ers on Thursday Night Football tonight, with both teams trying to save their chances in the NFC West. The loser is all but eliminated from division title contention, especially in the case of the 49ers. The Rams will still have a slim shot, but would be dependent on the Seahawks also losing several times.

With so much on the line at Levi's Stadium tonight, and so many injuries for San Francisco, who will step up and make a splash on TNF? Let's look at which 49ers can make a dent against the Rams, and which red-hot stars we should fade in our DraftKings Pick 6 entry for Rams vs. 49ers on TNF.

Rams vs. 49ers Date, Time and Where To Watch

• Date: December 12, 2024
• Time: 8:15 pm ET
• Where To Watch: Amazon Prime Video

Rams vs. 49ers DraftKings Pick 6 Picks

Leg 1: Deebo Samuel Over 53.5 Receiving Yards

We're starting this Pick 6 entry off with the most public leg ever, and that's Deebo to bounce back and go over. Everyone is looking at this spot, with Deebo complaining in the media this week about not getting the ball enough. And while we would usually go against that narrative, the 49ers simply have no weapons left. McCaffrey, Aiyuk, and Mason are all gone for the season, so it's literally Deebo and Kittle left, with a little Jennings action. At a certain point, it's not about if he'll get the ball, but how could he not. Rushing + Receiving yards wasn't available in the app at the time of this article, but that would be a good look as well if the line is less than 70 combined, because Deebo is going to get a serious amount of touches tonight. After going under this line for four games in a row and never eclipsing 22 yards, this line flew up four yards during the day today. We'll ride with the public as Deebo gets his lick back in prime time.

Leg 2: Puka Nacua Under 0.5 Touchdowns

Puka Nacua is the only offered TD over/under scorer for DK Pick 6 tonight, and we are going to grab his under. Not only is it beneficial odds as his real sportsbook odds are closer to +125 to score, but he is also one of the most public selections tonight. The implied odds give him a 44% chance of scoring a TD, so we'll fade that in a road divisional game that the 49ers need to save their season. They may not be as good as expected in scoring defense this year, allowing 23.7 points per game, but they will make an extra effort to lock down the Rams' top target. With Cooper Kupp, Kyren Williams, and Demarcus Robinson all in the mix to score, there is a lot of crowding at the top and other options for Stafford to go to. Nacua has scored in his last two games, but failed to find the end zone in three of the previous four. We will target him to regress on the road tonight as the 49ers pay special attention.

Leg 3: George Kittle Over 4.5 Receptions

The 49ers need this game bad, and they don't have any run game to rely on to set the tone. That is usually their go-to strategy, but with both Christian McCaffrey and Jordan Mason gone for the season after the Bills game two weeks ago, things have to change. They started to last week, as we saw George Kittle rack up six receptions for over 150 yards, his biggest game of the year. Brock Purdy is going to have to hit Kittle early and often tonight if the 49ers are going to have a shot at moving the ball. Look for him to haul in some easier grabs over the middle as a possession receiver, instead of the deeper shots that Deebo and Jauan Jennings might take. That's why we'll side with receptions over yards in this high-total matchup of 48.5.

Leg 4: Matthew Stafford Over 0.5 Interceptions

We're going to wrap it up with an INT leg here, as we can't pass up this opportunity in a divisional game. This is a high-stakes battle, and both teams will be airing it out tonight as they fight for positioning in the NFC West. More passes means more chances for an interception, and Stafford hasn't thrown one in the last four games. He has seven on the year however, and was throwing one pretty consistently up until the last month. He didn't throw one in the last matchup between this two earlier this year, and with the 49ers playing desperate ball tonight, they should be sending more blitzes and forcing Stafford to make a mistake late in this one. He's having a great year, but he can't go spotless forever, and there should be a chance tonight with the talent level on this defense.

DraftKings Pick6 Picks - Rams vs. 49ers

• Pick 1: Deebo Samuel Over 53.5 Receiving Yards
• Pick 2: Puka Nacua Under 0.5 Touchdowns
• Pick 3: George Kittle Over 4.5 Receptions
• Pick 4: Matthew Stafford Over 0.5 Interceptions