Rams vs. 49ers Prediction: Can Matthew Stafford, Rams Stay Hot Against Banged-Up 49ers on TNF?

Today, we’re in for a good game as these divisional matchups between the Rams and 49ers are always exciting. The NFC West is tightly contested, with the 49ers entering at 6-7 and the Rams at 7-6. This game has all the makings of a close battle! Let’s dive into the best bet for tonight’s game!

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Los Angeles Rams vs. San Francisco 49ers Odds

Los Angeles Rams vs. San Francisco 49ers Date, Time, and Where To Watch

• Date: December 12, 2024
• Time: 8:15 pm ET
• Where To Watch: Amazon Prime Video

Los Angeles Rams vs. San Francisco 49ers Prediction

This year has been challenging for the 49ers, who have dealt with a significant amount of injuries. Brandon Aiyuk is out for the season, and Christian McCaffrey is also sidelined after returning briefly from injury. Adding to their woes, star left tackle Trent Williams is ruled out, and Nick Bosa is questionable and unlikely to play. These injuries have heavily impacted the 49ers’ ability to perform consistently this season.

The Rams, on the other hand, are riding solid momentum. Matthew Stafford has been delivering excellent performances with his top targets, Cooper Kupp and Puka Nacua, who just lit the scoreboard up against a strong Bills defense. While the Rams defense has struggled against the run, they are positioned well against a depleted 49ers offense that lacks its key playmakers, and with no Christian McCaffrey or Jordan Mason, this is huge!

Overall, the Rams have been playing strong football recently, and this momentum should carry into tonight’s game. They have an excellent opportunity to cover the spread against a 49ers team that has been unable to overcome its injury challenges.

Los Angeles Rams vs. San Francisco 49ers Pick

• Pick: LA Rams +3 (-115) Get oddschecker+ right now for just $9.99 per month. Don't miss out on this December deal!