Cardinals vs. Cowboys Prediction, Betting Pick, Latest NFL Odds for Monday Night Football
The Dallas Cowboys will try to come out on the right side of a potential shootout on Monday Night Football between two struggling defenses. Dak Prescott and the Cowboys have been lighting up the scoreboard, but can they get stops against veteran Cardinals backup Jacoby Brissett? Let's take a look at this Cardinals vs. Cowboys prediction and best betting pick for MNF on November 3rd.
OC Staff - November 3, 2025, 8:00 AM EST
5 Minute ReadCardinals vs. Cowboys Prediction, Betting Pick, Latest NFL Odds for Monday Night Football
The Arizona Cardinals return from their bye looking to stop the bleeding after five straight losses, but they’ll have to do it without Kyler Murray once again. Veteran Jacoby Brissett gets another start under center, and while he’s yet to get Arizona over the hump, he’s kept them competitive against elite opponents like the Packers and Colts. The Cardinals have been close, but not quite there, and with head coach Jonathan Gannon’s seat starting to warm up, they’re running out of time to turn moral victories into actual wins.
On the other side, the Dallas Cowboys enter this Week 9 matchup at 4-4, still searching for consistency on both sides of the ball. The offense has been firing, with Dak Prescott clicking in rhythm alongside George Pickens and CeeDee Lamb, giving Dallas one of the league’s more dynamic passing attacks. The problem has been on defense, where the Cowboys rank 31st in points allowed — a shocking collapse for a unit once considered among the NFL’s elite.
Oddsmakers haven’t moved much on this game despite Murray’s absence, keeping the line at Cardinals +3 even as nearly 84% of bets pour in on Dallas. That suggests a potential trap spot for the Cowboys, who have struggled to put away lesser teams. If Brissett can continue to manage the game effectively and Arizona’s defense can create a few key stops, the Cardinals could be in prime position to pull off a much-needed upset and snap their losing streak.
Looking for advanced AI predictions and props to enhance your NFL betting? Try out oddschecker+ now on this limited time 7-day free trial!
Cardinals vs. Cowboys Date, Time, and Where to Watch
- Date: Monday, November 3, 2025
- Time: 8:15 PM ET
- How to Watch: ESPN
Cardinals vs. Cowboys Odds
Click here for the latest Cardinals vs. Cowboys Odds
Cardinals vs. Cowboys Prediction
On the other side of the ball, Cowboys QB Dak Prescott faces a daunting task against a surprisingly stout Arizona pass defense. Prescott is projected for 26 completions on 37 attempts, 272.5 yards, and 0.6 interceptions. However, his historical splits against Top-10 Pass Defenses tell a concerning story: a mere 76.6 Passer Rating, 169.5 passing yards per game, and a dismal 0.5 TD:INT ratio across three games. The Cardinals, despite their losing record, rank 10th in QB Rating Allowed, positioning them squarely as a top-tier pass defense in this critical metric. This creates a significant mental and statistical hurdle for Prescott, who has historically struggled to perform efficiently against elite secondaries.
While Dallas enjoys a perfect 2-0 home record and Arizona's pass rush is weak (26th in Sacks), giving Prescott potentially more time in the pocket, his ability to translate that time into effective throws against tight coverage will be the ultimate test. Can he elevate his game at home to overcome his historical struggles and penetrate Arizona's disciplined secondary? The outcome of this individual battle will largely determine the Cowboys' offensive rhythm and scoring potential.
In an offense where Dak Prescott might struggle against a top-tier pass defense, the performance of his top receiving target, George Pickens, becomes even more paramount. Pickens is projected for 4.8 receptions and 69.5 receiving yards, and our model has identified a significant edge on his Over 69.5 Receiving Yards at 1.909 odds (EV: 10.6%). This high-value opportunity suggests that even with the challenging matchup for Prescott, Pickens is poised to be a consistent and productive target.
Whether it's winning contested catches, finding open seams against tight coverage, or serving as Prescott's primary outlet on critical downs, Pickens' ability to exceed his yardage projection signals that he is expected to be a focal point regardless of the overall offensive efficiency. If Prescott faces pressure or struggles to read the defense, he will likely lean heavily on Pickens to make plays, especially in a game where offensive sparks will be at a premium.
Cardinals vs. Cowboys Pick
Pick: Cardinals +3 (-105) Check out these these best odds on DraftKings Sportsbook
More NFL Odds
Affiliate Disclosure.
We are not a gambling or betting operator, but we receive a commission from these companies when we advertise their brands and refer customers to them (affiliate marketing). We provide information, odds information and links to websites of these companies. Some of the information made available on our site may be positioned as a result of a commission paid to us by a third party. We do not take or place bets/transactions and any information on Our Products is provided for entertainment purposes only.
