NFL Week 10 Prop Pick Parlay: Targeting James Cook, Justin Jefferson to Shine on Sunday Afternoon
As we enter the second half of the NFL season, many NFL stars will have to play through injuries. Can James Cook step up on Sunday, and will we see a big game from Justin Jefferson? McBets is targeting both in his Week 10 NFL Prop Pick Parlay for Sunday, November 9th.
McBets - November 9, 2025, 11:00 AM EST
5 Minute ReadNFL Prop Pick Parlay: Can James Cook, Justin Jefferson Deliver in Week 10?
We’re rolling into Week 10 looking to stay hot, and this two-leg parlay sets up perfectly around two elite playmakers — both in favorable matchups and backed by strong data trends. Let’s break down why James Cook and Justin Jefferson are primed to deliver again this Sunday.
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NFL Week 10 Prop Pick Parlay: Sunday, November 9th
Leg 1: James Cook 70+ Rushing Yards
Cook has been one of the most consistent running backs in football this season, covering this number in six of his last seven games while averaging an impressive 117 rushing yards per game over that stretch. He’s already proven he can carve up this Dolphins defense — posting 108 yards back in Week 3 — and the matchup looks even better this time around.
Miami has struggled mightily against the run, allowing the third most rushing yards to opposing running backs this season. Combine that with the fact that Buffalo enters as 8.5-point favorites, and this game script screams “run-heavy.” If the Bills play with a lead as expected, Cook should see plenty of volume in the second half to comfortably clear this number again.
Leg 2: Justin Jefferson 50+ Receiving Yards
Jefferson has looked every bit like his old self since returning from injury, covering this line in six of his last seven games while averaging 86 receiving yards per game. He remains the clear focal point of the Minnesota passing attack with a massive 30.8% target share, which ensures steady volume regardless of matchup.
This week, he gets a Baltimore defense that’s been beatable through the air — allowing the seventh most receiving yards to opposing wide receivers this season. With J.J. McCarthy back under center, Jefferson should see plenty of early looks as the Vikings look to keep pace in what oddsmakers project as a shootout. The 48.5-point total is one of the highest on the slate, and that bodes well for Jefferson’s yardage floor and upside.
NFL Prop Pick Parlay (-111) Check out these best odds at DraftKings Sportsbook
- Leg 1: James Cook 70+ Rushing Yards
- Leg 2: Justin Jefferson 50+ Receiving Yards
Two alpha playmakers in great matchups, both with reliable usage and proven track records against these defenses. Expect Cook to set the tone on the ground while Jefferson lights up the scoreboard through the air.
This combo brings a balanced mix of efficiency and opportunity — a perfect recipe to keep the winning momentum rolling into Week 10.
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