Top Anytime Touchdown Scorer Picks for Rams vs. 49ers on Thursday, September 10th
The San Francisco 49ers face the Los Angeles Rams in Melbourne, Australia on Thursday night for the NFL's first regular-season game in the country. Can George Kittle, Puka Nacua and other key playmakers find the end zone in this historic international matchup? Check out these 49ers vs. Rams 3 anytime touchdown scorer picks for Thursday, September 10.
Peter Alexis - September 10, 2026, 3:30 PM EDT
4 Minute ReadWill Puka Nacua, Kyren Williams Find the End Zone in Australia Tonight?
The 49ers and Rams meet at the Melbourne Cricket Ground with a 48.5-point total, creating a much more appealing environment for touchdown props after Seattle and New England combined for just 23 points and two touchdowns Wednesday night. This rivalry also produced 49 points in an overtime meeting last October before exploding for 68 points when Los Angeles won the November rematch 42-26.
Familiarity has not prevented the stars in these offenses from finding the end zone, either. Kyren Williams has repeatedly punished San Francisco near the goal line, Puka Nacua scored in both meetings last season and George Kittle found the end zone in the most recent matchup. All three also have encouraging Thursday-night scoring histories, making the primary offensive weapons the preferred targets in what should be a much more touchdown-friendly primetime game.
Rams vs. 49ers Date, Time, and Where to Watch
- Date: Thursday, September 10th, 2026
- Time: 8:35 PM ET
- Location: Melbourne Cricket Ground, Melbourne, Australia
- How to Watch: Netflix
Rams vs. 49ers Odds
- Spread: San Francisco 49ers +3.5, Los Angeles Rams -3.5
- Total Points: Over 48.5, Under 48.5
Click here for the latest Rams vs. 49ers Odds
Rams vs. 49ers Best Anytime Touchdown Scorer Picks
1. Kyren Williams Anytime Touchdown Scorer (-130) Check out the best odds at DraftKings Sportsbook
Williams does not offer the biggest payout, but his history against San Francisco makes him difficult to leave off the card. He has scored nine touchdowns in five career games against the 49ers, including four across the two meetings last season. Williams caught two touchdown passes in the 26-23 overtime loss in October before rushing for two more scores when the Rams put up 42 points in the November rematch.
That production fits his broader role in Sean McVay's offense. Williams scored 13 total touchdowns last season and remains the back most likely to handle the Rams' valuable work near the goal line. Even with Blake Corum involved, Williams has consistently been trusted when Los Angeles reaches scoring territory, while his receiving ability creates another touchdown path if San Francisco sells out against the run.
There is also a strong statistical case behind the -130 price. The positive-EV model gives Williams a 63.15% chance to score compared to a 56.82% implied probability, creating 11.14% EV. He has scored in six of his last 10 games overall and has four touchdowns in seven career Thursday games, including both scores against San Francisco on Thursday Night Football last October.
2. George Kittle Anytime Touchdown Scorer (+300) Check out the best odds at DraftKings Sportsbook
Kittle at +300 provides the biggest price of the three, and his history in both this rivalry and Thursday games gives that number considerable appeal. He has seven touchdowns in 14 career regular-season games against the Rams and scored in his most recent appearance against them, catching all nine of his targets for 84 yards and a touchdown last November.
The primetime history is even more interesting. Kittle has six touchdowns across nine career Thursday games, the most by a 49ers player on Thursdays, and has produced multiple two-touchdown performances in the spot. That does not guarantee another score, but +300 is a large price for a player with a long track record of becoming a major part of Kyle Shanahan's offense in high-profile games.
Kittle's return also matters enormously to the structure of San Francisco's passing attack. After recording seven touchdowns in only 11 regular-season games last year, he remains one of Brock Purdy's best options in the middle of the field and near the goal line. The model gives him a 35.12% scoring probability against just a 25% implied probability at +300, resulting in a massive 40.48% EV. For a player who has scored in five of his last 10 games and has repeatedly hurt the Rams throughout his career, the price stands out.
3. Puka Nacua Anytime Touchdown Scorer (+130) Check out the best odds at DraftKings Sportsbook
Nacua enters the opener as one of the most important pieces in an already loaded Rams offense. He led the NFL with 129 receptions last season while finishing with 1,715 receiving yards, giving Matthew Stafford an extremely high-volume option who does not have to rely solely on traditional red-zone targets to find the end zone.
He has also developed a strong scoring trend against San Francisco. Nacua scored in both 2025 meetings, catching 10 passes for 85 yards and a touchdown in the Thursday overtime game before adding another touchdown in the Rams' 42-26 victory five weeks later. He now has three touchdowns in five career games against the 49ers, with 41 catches and 434 receiving yards across those matchups.
Thursday games have been particularly productive for Nacua recently. He has four touchdowns in five career Thursday appearances, including a touchdown against San Francisco last October and two more in a 225-yard performance against Seattle in December. His 54.49% AI scoring probability is well above the 43.48% implied probability at +130, creating 25.33% EV, while he has scored in six of his last 10 games. In a matchup carrying a 48.5 total, his combination of massive usage, rivalry success and recent primetime production makes +130 one of the strongest touchdown prices on the board.
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