Lions vs. Cardinals Prediction, Betting Pick, Latest NFL Week 5 Odds
The Detroit Lions travel to Arizona with both teams trying to rebound from disappointing Week 4 losses. Can Jared Goff and Detroit rediscover their early-season scoring form while Arizona attempts to exploit a Lions defense that struggled in Carolina? Check out this Lions vs. Cardinals prediction and best bet for Sunday, October 11.
Peter Alexis - October 11, 2026, 2:00 PM EDT
5 Minute ReadLions vs. Cardinals Prediction: Can Jared Goff, Lions Avoid Road Upset on Sunday Afternoon in Arizona?
Detroit fell to 2-2 after losing 32-26 at Carolina, while Arizona dropped to 1-3 following a 36-24 loss to the Giants. The Lions are five-point road favorites with the total rising to 54.5.
This is the highest-scoring market on Sunday's slate. Both recent results and the betting splits suggest another offensive game.
Lions vs. Cardinals Recent Results
Detroit Lions (2-2)
Detroit finally failed to reach 31 points for the first time this season but still scored 26 in Carolina. The bigger issue was a defense that could not get off the field consistently.
Jared Goff, Jahmyr Gibbs, Amon-Ra St. Brown and Sam LaPorta continue to give Detroit one of the deepest offensive groups in football.
Arizona Cardinals (1-3)
Arizona surrendered 36 points to New York one week after allowing 36 to San Francisco. The Cardinals have now given up 72 points over two games.
The offense has still shown enough life to contribute, scoring 30 against San Francisco and 24 against New York.
Lions vs. Cardinals Head to Head
- September 22, 2024: Detroit Lions 20, Arizona Cardinals 13
- December 19, 2021: Detroit Lions 30, Arizona Cardinals 12
- September 27, 2020: Detroit Lions 26, Arizona Cardinals 23
- September 8, 2019: Detroit Lions 27, Arizona Cardinals 27
Detroit has not lost to Arizona in the last four meetings and held the Cardinals to 13 points in the most recent matchup.
Lions vs. Cardinals Date, Time, Where to Watch
- Date: Sunday, October 11, 2026
- Time: 4:25 PM ET
- Location: State Farm Stadium, Glendale, Arizona
- How to Watch: FOX
Lions vs. Cardinals Odds
- Spread: Detroit Lions -5, Arizona Cardinals +5
- Total Points: Over 54.5, Under 54.5
- Moneyline: Detroit Lions -250, Arizona Cardinals +210
Click here for the latest Lions vs. Cardinals Odds
Lions vs. Cardinals Line Movement and Betting Splits
Detroit opened -5.5 and has moved to -5 despite receiving 65% of spread tickets and 71% of the handle.
The total has risen from 53 to 54.5. The over has 65% of bets and 76% of the money, producing a much cleaner directional signal.
Lions vs. Cardinals Team News and Injuries
Detroit's offensive core remains largely intact, allowing the Lions to continue building around Goff and Gibbs. The bigger injury questions have been on defense and along the offensive line.
Arizona has been dealing with defensive injuries in the secondary and on the edge. That is particularly problematic against a Detroit offense capable of attacking both underneath and vertically.
Lions vs. Cardinals Prediction
Detroit's offense remains the strongest unit in this matchup. Even in a loss, the Lions scored 26 points and moved the ball well enough to create repeated scoring opportunities.
Arizona's defense has become increasingly difficult to trust. Allowing 36 points in back-to-back games is a major concern before facing Goff and one of the NFL's deepest skill groups.
The Cardinals can contribute enough themselves. Detroit just allowed 32 to Carolina, showing that the defense is vulnerable when opponents maintain balance.
Arizona's rushing attack can also prevent the Lions from simply pinning their ears back and rushing the passer. That creates more opportunities for intermediate throws and play action.
The risk is that the total has already climbed into the mid-50s. Both offenses must participate for the over to cash.
The market still supports that outcome. The total has increased 1.5 points while 76% of the handle remains on the over.
A 31-27 or 34-24 Detroit win clears the number without requiring an extreme shootout.
Lions vs. Cardinals Best Bet
- Best Bet: Over 54.5 (-110) Check out these best odds at DraftKings Sportsbook
Arizona has surrendered 72 points over its last two games, while Detroit just allowed 32 in Carolina. Both offenses have clear matchup advantages, and the market continues moving upward with heavy over handle.
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