Johns Hopkins vs. Notre Dame Prediction, Betting Pick, Latest College Lacrosse Odds for NCAA Tournament Quarterfinal
The Notre Dame Fighting Irish will meet the Johns Hopkins Blue Jays on Saturday afternoon in Long Island. Can Hopkins keep it close, or will the Irish defense shut them down and advance to the Semifinal? Let's take a look at this Johns Hopkins vs. Notre Dame prediction and best betting pick for NCAA Lacrosse Tournament Quarterfinal on May 16th.
Peter Alexis - May 16, 2026, 10:15 AM EDT
4 Minute ReadJohns Hopkins vs. Notre Dame Prediction: Can Hopkins Continue Underdog Run Against No. 2 Irish?
Johns Hopkins and Notre Dame meet Saturday, May 16, at 12 p.m. ET at Shuart Stadium in Hempstead, New York, with a spot in Championship Weekend on the line. Notre Dame enters as the No. 2 seed and a heavy -350 favorite, while unseeded Johns Hopkins sits at +270 after stunning defending champion Cornell in the first round.
The spread is Notre Dame -3.5, but the better angle is under 20.5 total goals at -104. Hopkins is gritty enough to slow this game down and make Notre Dame work, but the Irish have the defensive structure, goaltending, and postseason experience to control the pace on a neutral field.
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Johns Hopkins vs. Notre Dame NCAA Lacrosse Odds
- Spread: Johns Hopkins +3.5 (+105), Notre Dame -3.5 (-120)
- Moneyline: Johns Hopkins (+275), Notre Dame (-335)
- Total: Over 20.5 (-110), Under 20.5 (-110)
Johns Hopkins vs. Notre Dame Date, Time, and Where to Watch NCAA Lacrosse Tournament Quarterfinal
- Date: Saturday, May 16, 2026
- Time: 12:00 PM ET
- Where to Watch: ESPNU
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Johns Hopkins vs. Notre Dame Prediction - NCAA Lacrosse Tournament
Notre Dame’s tournament opener was dominant. The Irish beat Jacksonville 18-5 behind a massive defensive and goaltending performance, with Thomas Ricciardelli making 18 saves while allowing only three goals. Luke Miller tied a program NCAA Tournament record with five goals, and Notre Dame improved to 11-2 while advancing to the quarterfinals for the fourth straight year. This is one of the most talented teams in the country, and the Irish have reached the title game twice in the last three seasons.
Johns Hopkins brings real upset confidence after beating Cornell 9-8 in overtime. Jimmy Ayers scored the winner, seven different Blue Jays found the net, and the defense held a defending champion offense to single digits in a hostile road environment. That win explains why Hopkins cannot be dismissed despite the +270 price, but it also points directly toward the total. The Blue Jays’ best chance is not trading goals with Notre Dame. It is turning this into a physical, low-possession game where every faceoff, clear, and settled possession matters.
The matchup should favor Notre Dame over 60 minutes. The Irish have more offensive balance, better tournament experience, and the defensive spine to handle Hopkins’ pace. Still, the Blue Jays are disciplined enough to keep this from becoming a full track meet, especially after proving they can drag a national title contender into a grind. On a neutral field in Long Island, the more likely script is Notre Dame gradually separating without the game exploding offensively.
Johns Hopkins vs. Notre Dame Best Bet
- Pick: Under 20.5 Total Goals (-104) Check out the best odds at FanDuel Sportsbook
Notre Dame should overpower Hopkins and advance, but the total is the cleaner betting angle because both teams have clear defensive paths. Hopkins just won a 9-8 grinder against Cornell, while Notre Dame is coming off a game where its goalie and defense completely shut down Jacksonville. Expect a locked-in quarterfinal where the Irish win, but the pace and pressure keep this under the number.
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