Liverpool vs Atletico Madrid Prediction, Betting Pick, Latest Champions League Odds
Liverpool and Atletico Madrid will open up their 2025-26 Champions League campaigns on Wednesday night at Anfield. Can Mo Salah and Liverpool win as heavy favorites at home? Let's take a look at our Liverpool vs. Atletico Madrid prediction and best betting pick for the Champions League opener.
OC Staff - September 17, 2025, 12:10 PM EDT
4 Minute ReadLiverpool vs Atletico Madrid Prediction: Can Liverpool Shut Out Atletico in Champions League Opener?
Liverpool will host Atletico in the Champions League at Anfield on Wednesday, September 17, 2025, at 19:00 UTC.
Liverpool vs Atletico Form
Liverpool are currently sitting in 27th position in the league standings. In their most recent match, they secured a narrow 1-0 victory against Burnley.
Atletico, positioned 15th in the league, enters this match on the back of a 2-0 win against Villarreal.
Liverpool vs Atletico Head to Head
The historical record between these two clubs suggests a balanced rivalry. Over the past six encounters, Liverpool have won three matches, while Atletico have secured two victories, with one game ending in a draw.
The last time they met, Liverpool emerged victorious with a 2-0 win in the Champions League back in November 2021.
Looking for advanced AI predictions and props to enhance your soccer betting? Try out oddschecker+ now on this limited time 7-day free trial!
Liverpool vs. Atletico Odds
Click here for complete Liverpool vs. Atletico Odds
Liverpool vs Atletico Probable Lineups
Liverpool (4-2-3-1): G. Mamardashvili; A. Robertson, V. v. Dijk, I. Konaté, J. Frimpong; A. M. Allister, R. Gravenberch; F. Chiesa, F. Wirtz, M. Salah; H. Ekitiké
Atletico (4-4-2): J. Oblak; M. Ruggeri, C. Lenglet, J. Galán, M. Llorente; N. González, P. Barrios, Koke, G. Simeone; J. Alvarez, A. Griezmann
Liverpool vs Atletico Team News
Liverpool will be without M. Kerkez and C. Jones due to injury. S. Bajcetic is doubtful for the match. Alexander Isak's fitness is still being built up, and while he could make his Liverpool debut on Wednesday night, it is likely to be from the bench. G. Mamardashvili could get his opportunity to shine in the cups with Alisson being the clear number one in the Premier League.
Atletico are facing several injury concerns, with Á. Baena, R. L. Normand, and D. Hancko all ruled out. J. M. Giménez and T. Almada are doubtful. J. Galán is expected to fill in the back four, while Conor Gallagher is pushing for a recall in midfield.
Liverpool vs Atletico Match Facts
- Liverpool have kept a clean sheet in their last 3 home matches against Atletico in all competitions.
- Liverpool have been winning at both half time and full time in their last 3 home matches against Atletico in all competitions.
- Liverpool have seen under 2.5 goals in 6 of their last 7 matches against Atletico in all competitions.
- Liverpool have won their last 3 home matches against Atletico in all competitions.
Liverpool vs Atletico Prediction
Liverpool relied on a 94th-minute Mohamed Salah penalty to secure a 1-0 away win against newly promoted Burnley on Sunday, narrowly avoiding a humbling result on the road at Turf Moor. Arne Slot's side are off to a perfect start for their Premier League title defence, recording four consecutive victories to kick off the new campaign ahead of this Champions League clash.
While Liverpool have started their league campaign in fine form, the same cannot be said for their visitors. Atletico Madrid were beaten 2-1 by Espanyol on the opening weekend of the La Liga season, and followed up that result with back-to-back draws. A 2-0 win against Villarreal on Saturday finally launched Diego Simeone's side's campaign, but they now face a daunting task at Anfield on Wednesday night.
- Prediction: Liverpool 2-0 Atletico
Liverpool vs Atletico Best Bet
With Liverpool's strong home record against Atletico, including three consecutive clean sheets, backing them to win without conceding seems a solid bet.
- Best Bet: Liverpool to Win to Nil (+162) Click here to get the best odds at Bet365 Sportsbook
More Soccer Odds
Affiliate Disclosure.
We are not a gambling or betting operator, but we receive a commission from these companies when we advertise their brands and refer customers to them (affiliate marketing). We provide information, odds information and links to websites of these companies. Some of the information made available on our site may be positioned as a result of a commission paid to us by a third party. We do not take or place bets/transactions and any information on Our Products is provided for entertainment purposes only.
