Southampton vs Arsenal Prediction, Betting Pick, Latest FA Cup Odds
The FA Cup quarter-final clash sees Championship high-flyers Southampton host Premier League giants Arsenal at St Mary's Stadium on Friday, 4th April 2026, with kick-off scheduled for 19:00 BST. While the Saints are pushing for promotion in their league campaign, the Gunners are battling at the sharp end of the Premier League and Champions League, setting the stage for a classic cup encounter.
OC Staff - April 4, 2026, 12:00 PM EDT
3 Minute ReadSouthampton vs Arsenal: Lineups, Team News and Prediction
The FA Cup quarter-final clash sees Championship high-flyers Southampton host Premier League giants Arsenal at St Mary's Stadium on Friday, 4th April 2026, with kick-off scheduled for 19:00 BST. While the Saints are pushing for promotion in their league campaign, the Gunners are battling at the sharp end of the Premier League and Champions League, setting the stage for a classic cup encounter.
Southampton vs Arsenal Form
The home side enters this FA Cup tie in strong form, having secured a 2-0 victory over Oxford in their last outing in the Championship. This win extends an impressive run for the Saints, who have not lost in their last six matches across all competitions. Their recent fixtures include a hard-fought 1-0 win against Norwich, a 2-1 away victory at Coventry, and a 1-1 draw against WBA. In the FA Cup, they notably overcame Fulham with a 1-0 away win, following a 3-1 league success against Sheffield Wednesday. This consistent form highlights a resilient and capable unit.
Arsenal, meanwhile, faced a 2-0 defeat against Manchester City in the League Cup in their most recent fixture. The Gunners have experienced a mixed bag of results in their last six, including a 2-0 Champions League win over Leverkusen and a comfortable 2-0 Premier League victory against Everton. Away from home, they drew 1-1 with Leverkusen in the Champions League and secured a 2-1 FA Cup win over Mansfield, alongside a narrow 1-0 Premier League triumph at Brighton. The visitors have seen over 2.5 goals in their last three matches against Southampton in all competitions, suggesting a potentially open game.
Southampton vs Arsenal Head to Head
The most recent encounter between these two sides saw Southampton fall to a 2-1 defeat against Arsenal in the Premier League in May 2025.
Looking at their last six meetings, the rivalry has been keenly contested. Arsenal have edged out the Saints with three wins, while Southampton have managed one victory, and two matches have ended in draws. The Gunners have also demonstrated a strong attacking prowess in this fixture, scoring at least two goals in their last three matches against the home side.
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Southampton vs. Arsenal Odds
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Southampton vs Arsenal Probable Lineups
Southampton (4-2-3-1):
- Goalkeeper: Peretz
- Defenders: Manning, Stephens, Harwood-Bellis, Bree
- Midfielders: Charles, Downes
- Attacking Midfielders: Scienza, Azaz, Fellows
- Forward: Larin
Arsenal (4-2-3-1):
- Goalkeeper: Arrizabalaga
- Defenders: Lewis-Skelly, Calafiori, Mosquera, White
- Midfielders: Nørgaard, Zubimendi
- Attacking Midfielders: Trossard, Ødegaard, Dowman
- Forward: Jesus
Southampton vs Arsenal Team News
Southampton will be without Roerslev due to injury, who is ruled out for the rest of the season. Welington is doubtful with a muscle problem, and Robinson also faces a late fitness test for a quad issue. Leo Scienza is expected to return from a groin injury and could feature.
Arsenal are facing a more significant injury crisis, with Mikel Arteta expected to rotate his squad heavily given upcoming Premier League and Champions League commitments. Eze and Madueke are both injured. Doubtful players include Magalhães, Rice, Saliba, Saka, Timber, Hincapié, Zubimendi, and captain Ødegaard, who is hoping to return from a knee injury. Kepa Arrizabalaga is likely to start in goal despite recent errors.
Southampton vs Arsenal Match Facts
- Southampton have seen over 2.5 goals in their last 3 matches against Arsenal in all competitions.
- Arsenal have scored at least 2 goals in their last 3 matches against Southampton in all competitions.
Prediction: Southampton 0-3 Arsenal
While Southampton's current form in the Championship is commendable, Arsenal's superior quality and depth, even with a rotated squad, should prove too much for the hosts. The Gunners possess a potent attack, highlighted by their average of 1.7 shots on target per game and their ability to create chances through individual skill and direct attacks. Despite facing a resilient Southampton side that excels at creating scoring chances and attacking down the wings, Arsenal's solid defensive organisation and ability to cope with set-pieces will be crucial. The visitors' high possession and accurate passing will allow them to control the tempo, exploiting Southampton's weakness in defending against skillful players. Given the Gunners' strength in depth, even with key players rested, they are expected to dominate this FA Cup tie.
Best Bet: Arsenal to Win and Over 2.5 Goals Click here to get the best odds at Caesars Sportsbook
Considering Arsenal's predicted 3-0 victory and the historical fact that both teams have seen over 2.5 goals in recent head-to-head encounters, backing Arsenal to win with over 2.5 goals scored in the match offers a valuable betting angle. Arsenal's consistent scoring record against Southampton (at least two goals in their last three meetings) further supports this outcome.
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