Roma vs Inter Milan Lineups, Prediction, Betting Picks & Odds
Roma vs Inter Milan square off in Serie A action. Check our game prediction, projected starting lineups, key odds, and smart picks ahead of this showdown.
Grayson Parker - September 19, 2026, 8:12 AM EDT
7 minutesRoma vs Inter Milan Game Preview
Competition | Italian Serie A |
|---|---|
Game Date | September 19, 2026 |
Game Time | 12:00 PM ET / 9:00 AM PT |
Venue (City, Stadium) | Rome, Stadio Olimpico |
The Roma vs Inter Milan prediction headlines Matchday 5 at the Stadio Olimpico, where two unbeaten sides meet with perfect records and a top-of-the-standings showdown on the line.
Roma sit joint-top after winning all four of their opening games, banking 12 points and riding a scoring streak led by Donyell Malen, who has six goals already.
Inter arrive level with Roma on 12 points from four wins, unbeaten across 14 Serie A outings and boasting the meanest attacking numbers in the standings.
There is real history here too: Inter have won their last five away games against Roma in all competitions, giving the visitors a psychological edge in this matchup.
Roma vs Inter Milan Recent Results
Roma are flying, winning their last nine games in Serie A and scoring at least twice in every one of them. They have also kept a clean sheet in five of their last six league games, blending ruthless attack with a stubborn back line. Donyell Malen leads the charge with six goals in the opening four games, and the 2-0 win at Torino showed their control.
Inter are just as hot, going 14 straight without a loss in Serie A and scoring at least two goals in 10 of their last 12 league outings. Their attack looks relentless, with Marcus Thuram and Lautaro Martinez leading the line. The recent 5-3 comeback win over Udinese, after trailing 2-0, underlined both their firepower and their willingness to trade blows.
Roma vs Inter Milan Lineups & Team News
Injuries & Suspensions
Roma: No injuries or suspensions reported.
Inter Milan: Hakan Calhanoglu (Injured/out), John Stones (Injured/out), Djed Spence (Unfit/out).
Roma
Roma have a fully fit squad, welcoming back both Evan Ndicka and Wesley, who are both expected to start against Inter in place of Balerdi and Lulli, though Wesley is in a selection battle with Molina. Manu Kone returns in midfield alongside Cristante. Up front, Soule is favored over Rodrigo Mora to partner Paulo Dybala behind Malen, who has already scored six goals in the opening four games.
Inter Milan
Inter will be without Hakan Calhanoglu, who suffered a muscle injury and returns after the international break, with Zielinski stepping into deep-lying midfield and Barella and Jones as box-to-box runners. Dimarco returns on the left after a knee issue, while Spence is not ready, so Diouf plays on the right. Stones is out injured, leaving Bisseck, Akanji and Bastoni as the back three, with Josep Martinez confirmed in goal.
Roma vs Inter Milan Predicted Lineup
Roma
Formation: 3-4-1-2 (probable)
Predicted Starting Lineup: Svilar; Mancini, Ndicka, Hermoso; Wesley, Kone, Cristante, Molina; Soule; Dybala, Malen
Inter Milan
Formation: 3-5-2 (probable)
Predicted Starting Lineup: J. Martinez; Bastoni, Akanji, Bisseck; Dimarco, Barella, Zielinski, Jones, Diouf; Thuram, L. Martinez
Roma vs Inter Milan Key Stats & Game Facts
- Roma have received 2+ cards in 9 of their last 10 games vs Inter (Serie A).
- Inter have had 7+ shots on target in 3 of their last 3 games (Serie A).
- Marcus Thuram has scored in 3 of their last 4 games vs Roma (Serie A).
- Paulo Dybala has recorded 1+ shots on target in 7 of their last 10 games vs Inter (Serie A).
- Alessandro Bastoni has committed 2+ fouls in 5 of their last 5 games vs Roma (Serie A).
Roma vs Inter Milan Prediction & Best Picks
Our Prediction
This one has fireworks written all over it. Both sides are unbeaten and score for fun, so our prediction leans toward a high-scoring affair that ends in a 2-2 tie. Inter edge the numbers as the slight favorite, but Roma's home firepower keeps this level.
Best Picks
Inter Milan to win against Roma in the Match Result market. In the Moneyline market, Inter come in as the away favorite on a 41.72% implied probability, and the visitors carry real weight here — going undefeated in 14 straight Serie A games and having won their last five away trips to Roma in all competitions.
Both teams to score (Yes) in Roma vs Inter Milan. In the Both Teams To Score market, the numbers point firmly toward goals at both ends, with a 66.53% implied probability on both teams finding the net. Roma have hit at least twice in each of their last nine league games, while Inter have scored two or more in 10 of their last 12 outings.
Roma vs Inter Milan Same Game Parlay
Our Roma vs Inter Milan Same Game Parlay picks lean into a physical, high-shot game: Gianluca Mancini carded, Donyell Malen over 2.5 shots, Malen to score anytime, and over 1.5 total home goals.
Mancini has been carded in 7 of his last 10 games against Inter, and this matchup is exactly the sort of feisty derby that draws a yellow from the Roma defender.
Donyell Malen over 2.5 player shots is our second leg, with the forward attempting 3+ shots in each of his last four Serie A games as Roma's main threat.
Malen to score anytime backs up that shot volume, as he has found the net in three of his last four league appearances and already has six goals this season.
Over 1.5 total home goals rounds it out, with Roma scoring at least twice in each of their last nine Serie A games at a rampant clip.
At the time of writing, this Same Game Parlay pays a best price of +926 and is as short as +775 elsewhere. That represents a gap of $15 in profit on a $10 stake from top price to bottom.
Shop around for the sharpest price on your Roma vs Inter Milan Same Game Parlay using Oddschecker's Same Game Parlay Comparison Tool.
Same Game Parlay odds correct at time of publishing.
Roma vs Inter Milan Talking Points
Two perfect records collide, and something has to give. Roma have won all four of their opening games and Inter have done the same, leaving both clubs joint-top with 12 points and level on style points too. Roma boss Gian Piero Gasperini set the tone in his press conference at Trigoria, calling Inter "the strongest side in our league and have been for some years," framing the visitors as the benchmark his team is chasing. The soccer reasoning matches the talk: Inter's 5-3 comeback over Udinese, after trailing 2-0, showed a side that can outscore anyone, while Roma's 2-0 win at Torino, sealed by Malen and Pisilli, showed control at both ends. This one has the makings of a genuine, direct heavyweight matchup.
Roma vs Inter Milan Predictions FAQs
When is the Roma vs Inter Milan game?
The Roma vs Inter Milan game takes place on Saturday, September 19, 2026, with kickoff scheduled for 12:00 PM ET / 9:00 AM PT.
Where is the Roma vs Inter Milan game being played?
The game is being played at the Stadio Olimpico in Rome.
What is the latest team news for Roma vs Inter Milan?
Roma welcome back Evan Ndicka and Wesley to their squad. Inter Milan will be without the injured Hakan Çalhanoğlu and John Stones, while Djed Spence remains unavailable.
Who is projected to start in attack for Roma and Inter Milan?
Roma are expected to start Paulo Dybala and Donyell Malen up front. Inter Milan are projected to start Marcus Thuram alongside Lautaro Martinez.
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