
Liverpool vs Villarreal Lineups, Prediction, Betting Picks & Latest Champions League Odds
Liverpool vs Villarreal lineups, injury news and betting picks for Tuesday's Champions League game. Covers the prediction, odds and Same Game Parlay.
Cody Moore - October 20, 2026, 2:27 PM EDT
6 minutesLiverpool vs Villarreal Game Preview
Competition | UEFA Champions League |
|---|---|
Game Date | Tuesday, October 20, 2026 |
Game Time | 3:00 PM ET / 12:00 PM PT |
Venue (City, Stadium) | Anfield |
Champions League soccer comes to Anfield on Tuesday, and Liverpool's attack makes them the clear side to back against a Villarreal team that is still finding its feet.
Andoni Iraola's Liverpool have a perfect record in this competition so far, but muscle injuries to Dominik Szoboszlai and Jeremie Frimpong leave two notable holes in the squad.
Íñigo Pérez's Villarreal lost their European opener at Borussia Dortmund, then bounced back by beating Napoli at home. Getting a result at Anfield is a much tougher assignment.
Liverpool have won their last 3 games against Villarreal in all competitions. The Liverpool vs Villarreal betting odds agree, with Liverpool priced at -188 (Polymarket) on the moneyline.
Liverpool vs Villarreal Recent Results
Liverpool have won six of their last eight games in all competitions, a run that includes a 6-3 rout of LASK and a win over Atlético Madrid to keep their Champions League record perfect. At home in the league, the Brentford game proved costly with two muscle injuries, but Florian Wirtz and Alexander Isak still give this attack real teeth.
Villarreal have struggled in their domestic league, but they have improved in recent weeks. The 3-1 Champions League win over Napoli steadied things after the loss at Dortmund, and Georges Mikautadze scored in it. The problem is travel. Villarreal have won just once in six away games this season.
Liverpool vs Villarreal Lineups & Team News
Injuries & Suspensions
Liverpool: Jeremie Frimpong (Injured/out), Dominik Szoboszlai (Injured/out)
Villarreal: Absence list not yet available
Liverpool
Szoboszlai and Frimpong both picked up muscle injuries against Brentford and face extended spells on the sidelines. The good news for the Liverpool vs Villarreal lineups is that Ryan Gravenberch is back from suspension and should slot in beside Alexis Mac Allister in midfield. Cody Gakpo could also return after being benched at the weekend.
Villarreal
Georges Mikautadze is expected to keep his starting spot after scoring against Napoli. Pape Gueye and Santi Comesaña should anchor central midfield, Pau Navarro and Renato Veiga look set to continue at center back, and Luiz Júnior is expected to start in goal.
Liverpool vs Villarreal Predicted Lineup
Liverpool
Formation: 4-2-3-1 (probable)
Predicted Starting Lineup: Probable XI: A. Becker; J. Gomez, V. v. Dijk, J. Jacquet, K. Tsimikas; Ryan Gravenberch, Alexis Mac Allister; Bradley Barcola, Florian Wirtz, Cody Gakpo; Alexander Isak
Villarreal
Formation: 4-2-2-2 (probable)
Predicted Starting Lineup: Probable XI: Luiz Júnior; C. Romero, Renato Veiga, Pau Navarro, S. Mouriño; Pape Gueye, Santi Comesaña; A. Moleiro, N. Saliba; G. Moreno, Georges Mikautadze
Liverpool vs Villarreal Prediction & Best Picks
Our Prediction
Our Liverpool vs Villarreal prediction is a 3-1 Liverpool win. Isak, Wirtz and company bring far more firepower than a Villarreal side that has won once in six away games this season, and Anfield should amplify that gap. Mikautadze gives the visitors enough of an outlet to grab a goal, but Liverpool are the stronger team and should control this one.
Best Picks
Both Teams To Score: Yes. Villarreal's attack, led by Mikautadze, should find a way past a Liverpool side missing key players. This one sits in the Both Teams To Score market, and it is the first of our Liverpool vs Villarreal best picks. Our projections have both sides scoring 64.1% of the time, which is higher than the implied probability in the Yes price, and Liverpool's injury list gives Mikautadze something to aim at.
Total Goals Over/Under: Over 3.5 goals. An open, high-scoring Champions League night at Anfield. This selection comes from the Total Goals Over/Under market. Our projected total lands at 3.53 goals, matching the 3-1 call above, and the line has climbed since it opened, pointing to a game that should produce plenty of goals at both ends.
Liverpool vs Villarreal Same Game Parlay
Our Liverpool vs Villarreal same game parlay picks stack a Liverpool moneyline, Alexander Isak to score anytime, both teams to score and a card for Santiago Mouriño.
Liverpool Moneyline: Liverpool have won 3 of the previous meetings between these clubs. Villarreal have managed just one win in that head-to-head, and Anfield tilts the matchup further.
Alexander Isak Anytime Goalscorer: Isak leads the line in a probable attack alongside Wirtz, Barcola and Gakpo, and our projections make his anytime goal close to a coin flip.
Both Teams To Score: Yes: Liverpool have scored multiple goals in each of their last 3 games against Villarreal in all competitions, and Mikautadze gives the visitors a real outlet.
Santiago Mouriño To Be Shown A Card: Our projections put this at roughly one in three, and he figures to be busy against a Liverpool attack that should have plenty of the ball.
Shop around before locking this Same Game Parlay in. Oddschecker's Same Game Parlay Comparison Tool lines up prices from multiple books so you land the strongest payout.
Same Game Parlay odds correct at time of publishing.
Liverpool vs Villarreal Talking Points
The sideline storyline is a good one. Andoni Iraola and Íñigo Pérez are former Athletic Club teammates, and Pérez served as Iraola's assistant at Rayo Vallecano during the 2022-23 season. Iraola called the matchup a privilege, saying, "He knows me very well, he knows everything," before adding that "it is going to be a little bit strange, yes, but in a good way." There is another Liverpool link in the Villarreal squad too. Goalkeeper Péter Gulácsi was once on Liverpool's books and sat on the first-team bench 51 times without ever making a competitive appearance.
Liverpool vs Villarreal Predictions FAQs
When is the Liverpool vs Villarreal Champions League game?
The game is on Tuesday at 3:00 PM ET / 12:00 PM PT.
Where is Liverpool vs Villarreal being played?
The game is being played at Anfield.
Where can I watch Liverpool vs Villarreal?
The listed broadcaster for this game is Amazon Prime, based on a UK listing.
Who is in the probable lineups for Liverpool vs Villarreal?
Liverpool's probable formation is 4-2-3-1 and Villarreal's is 4-2-2-2. Dominik Szoboszlai and Jeremie Frimpong are listed as injured for Liverpool.
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