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Frosinone vs Sassuolo Lineups, Prediction, Betting Picks & Odds

Frosinone vs Sassuolo Lineups, Prediction, Betting Picks & Odds

Frosinone vs Sassuolo picks, probable lineups, odds and Same Game Parlay angles. Team news, injury updates and game prediction ahead of Friday's kickoff.

Frosinone vs Sassuolo Game Preview

Competition

Italian Serie A

Game Date

Friday, October 16, 2026

Game Time

2:45 PM ET / 11:45 AM PT

Venue (City, Stadium)

Stadio Benito Stirpe

Frosinone host Sassuolo at the Stadio Benito Stirpe on Friday, and the Frosinone vs Sassuolo betting odds barely separate two Serie A sides sitting just two points apart in the standings.

Frosinone come in off a 3-0 loss at Napoli. Massimiliano Alvini's side still love to counter, fire away from everywhere and play with real width.

Sassuolo tied AC Milan 1-1 at home last time out. Alberto Aquilani's group create through individual skill, with Domenico Berardi and Armand Laurienté the danger men out wide.

The visitors have enjoyed this trip. Sassuolo have taken care of business on the road here, winning 5 of their last 6 away games against Frosinone in all competitions.

Frosinone vs Sassuolo Recent Results

Frosinone are sitting at 4 wins from their last 10 games against all opponents, which is respectable rather than spectacular. The attack is where they earn their keep. Giorgi Kvernadze has a goal or an assist in 4 of his last 5 Serie A outings, and he gives this 4-3-3 a genuine outlet down the left.

Sassuolo have only 3 wins in their own last 10 games against all opponents, so this is no juggernaut on paper. The selling point is firepower. Berardi and Laurienté supply the individual quality on the flanks, Vasilije Adzic keeps arriving from midfield, and Nemanja Matic brings the experience in the middle of the field.

Frosinone vs Sassuolo Lineups & Team News

Injuries & Suspensions

Frosinone: Daniel Bîrligea (Injured/out), Florian Grillitsch (Injured/out)

Sassuolo: Daniel Boloca (Injured/out), Ismaël Koné (Injured/out), Edoardo Pieragnolo (Injured/doubtful), Fedde Leysen (Injured/doubtful)

Frosinone

The Frosinone vs Sassuolo lineups mirror each other, and Massimiliano Alvini's probable 4-3-3 has Lorenzo Palmisani in goal behind Gabriele Bracaglia, Giorgio Cittadini, Gabriele Calvani and Anthony Oyono. Patrizio Masini, Giacomo Calò and Romano Schmid make up the midfield, while Kvernadze and Farès Ghedjemis flank striker Antonio Raimondo. Daniel Bîrligea and Florian Grillitsch are both out injured.

Sassuolo

Alberto Aquilani's probable 4-3-3 starts with Arijanet Muric in goal and a back four of Josh Doig, Cas Odenthal, Duje Caleta-Car and Simone Cinquegrano. Kristian Thorstvedt, Matic and Adzic run the midfield, with Laurienté and Berardi on the wings around Sebastiano Esposito. Daniel Boloca and Ismaël Koné are injured, while Edoardo Pieragnolo and Fedde Leysen are doubtful.

Frosinone vs Sassuolo Predicted Lineup

Frosinone

Formation: 4-3-3

Predicted Starting Lineup: Lorenzo Palmisani; Anthony Oyono, Gabriele Calvani, Giorgio Cittadini, Gabriele Bracaglia; Patrizio Masini, Giacomo Calò, Romano Schmid; Farès Ghedjemis, Antonio Raimondo, Giorgi Kvernadze

Sassuolo

Formation: 4-3-3

Predicted Starting Lineup: Arijanet Muric; Simone Cinquegrano, Duje Caleta-Car, Cas Odenthal, Josh Doig; Kristian Thorstvedt, Nemanja Matic, Vasilije Adzic; Domenico Berardi, Sebastiano Esposito, Armand Laurienté

Frosinone vs Sassuolo Key Stats & Game Facts

  • Sassuolo have had 18+ shots in 5 out of 6 games against Frosinone in Serie A.
  • There have been 10+ shots on target in 6 of Sassuolo's last 6 games in Serie A.
  • Vasilije Adzic has scored in 3 of his last 4 appearances in Serie A.
  • Domenico Berardi has won 3+ fouls in 4 of his last 5 appearances against Frosinone in Serie A.
  • Sassuolo have received 2+ cards in 6 of their last 6 games against Frosinone in Serie A.

Frosinone vs Sassuolo Prediction & Best Picks

Our Prediction

Our Frosinone vs Sassuolo prediction is a wide-open, end-to-end game with both nets rippling and the result too close to call. Frosinone are only marginal favorites on the moneyline at +150 (Polymarket), and Sassuolo's quality on the wings keeps them right in it. These are two sides that take a lot of shots and leave the door open at the back, so we are backing goals rather than picking a winner.

Best Picks

Both teams to score: Yes in the Both Teams To Score market. Both sides carry a clear attacking threat in a fixture with a high projected goal count. Both Teams To Score is the cleanest of our Frosinone vs Sassuolo best picks. The projection has both sides scoring 69.8% of the time, and Sassuolo have found the net at least twice in 6 of their last 7 away games against Frosinone in all competitions.

Over 3.5 in the Total Goals Over/Under market. It backs an open, high-scoring game between two attack-minded sides. The Total Goals Over/Under line has already climbed to 3.5, a sign of where this one is heading. The projected total sits at 3.61, and with Frosinone shaky defending counters and set pieces while Sassuolo struggle to protect a lead, this has shootout written all over it.

Frosinone vs Sassuolo Same Game Parlay

Our Frosinone vs Sassuolo Same Game Parlay picks lean into the visitors' attack: Berardi shots, Adzic to score, both teams to score and a Bracaglia card.

Domenico Berardi Over 3.5 in the Player Shots market. He has attempted 4+ shots in every one of his last 5 appearances against Frosinone in Serie A.

Vasilije Adzic in the Anytime Goalscorer market. The midfielder has found the back of the net in 3 of his last 4 Serie A outings and is in line to start next to Matic.

Yes in the Both Teams To Score market. Sassuolo have hit this in 6 of their last 6 Serie A games, and it lines up with our best pick.

Gabriele Bracaglia in the To Be Shown A Card market. The left back has been carded in 2 of his last 3 games and draws the job of tracking Berardi.

Make sure to get the best odds on your Same Game Parlay with Oddschecker's Exclusive Same Game Parlay Comparison Tool.

Same Game Parlay odds correct at time of publishing.

Frosinone vs Sassuolo Talking Points

The pregame ceremony says plenty about Frosinone's start. Massimiliano Alvini was named Serie A Coach of the Month for August and September, and Antonio Raimondo picked up the Rising Star award after scoring four goals in his opening five league games. Both awards are presented before kickoff. Alberto Aquilani has already called the Stadio Benito Stirpe a tough place where visiting teams struggle, and he wants his side to match Frosinone's intensity and show more bite in front of goal. Put a confident home attack up against a visiting forward line full of individual quality and you get the open, messy game we are expecting.

Frosinone vs Sassuolo Predictions FAQs

When is the Frosinone vs Sassuolo Italian Serie A game?

Friday's game kicks off at 2:45 PM ET / 11:45 AM PT.

Where is Frosinone vs Sassuolo being played?

The game is being played at Benito Stirpe.

What are the probable lineups for Frosinone vs Sassuolo?

Both sides are listed as probable in a 4-3-3 formation. Frosinone's probable XI includes Lorenzo Palmisani in goal and Antonio Raimondo up front, while Sassuolo's includes Arijanet Muric in goal and Domenico Berardi among the attackers.

What is the recent head-to-head record between Frosinone and Sassuolo?

Sassuolo have won 5 of their last 6 away games against Frosinone in all competitions. They have also scored at least 2 goals in 6 of their last 7 away games against Frosinone in all competitions.

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