Real Betis vs Feyenoord Lineups, Prediction, Betting Picks & Odds

Real Betis vs Feyenoord Game Preview

Real Betis host Feyenoord at Estadio La Cartuja de Sevilla in the Champions League. The hosts bring a perfect record in the competition into this one.

Manuel Pellegrini's side are coming off a 5-2 home loss to Barcelona in La Liga. A heavily rotated lineup took that hit, and several regulars are now back.

Feyenoord bounced back from a loss to Barcelona by edging Como 3-2. The bad news for Giovanni van Bronckhorst is an injury list that runs nine names deep.

Betis hold the edge in previous meetings with one win and one tie. Feyenoord are still waiting for their first win against them.

Real Betis vs Feyenoord Recent Results

Betis have been perfect in the Champions League, coming from behind to beat Lille and Porto 3-2 apiece. Things have been shakier at home in La Liga, where a heavily rotated side got thumped 5-2 by Barcelona on Saturday. Isco, Natan and Marc Bartra are due back, and that matters more than the weekend scoreline.

Feyenoord finished as Eredivisie runners-up to earn a direct Champions League spot, then got welcomed to the competition with a 5-1 beating by Barcelona. They answered by taking down Como 3-2. Nacho Ferri, a summer addition, leads the line as the focal point of the attack.

Real Betis vs Feyenoord Lineups & Team News

Injuries & Suspensions

Real Betis: J. Firpo (Injured/out)

Feyenoord: T. Beelen (Injured/out), B. Nieuwkoop (Injured/out), G. Smal (Injured/out), J. Moder (Injured/out), J. Bos (Injured/out), S. v. Persie (Injured/out), T. Watanabe (Injured/out), G. Borges (Injured/out), R. Nelson (Injured/out)

Real Betis

Facundo Bernal was sent off against Barcelona in La Liga but is available for selection on Wednesday. The bigger story is who returns: Natan, Marc Bartra and Isco all come back into the probable lineup. Up top, Troy Parrott replaces Cucho Hernandez.

Feyenoord

Javi Lopez and Oussama Targhalline could be recalled for the trip to Seville, and both feature in the probable XI. The Real Betis vs Feyenoord lineups tell the story of the visitors' week, though, because their injury list includes Reiss Nelson and Jordan Bos.

Real Betis vs Feyenoord Predicted Lineup

Real Betis

Formation: 4-2-3-1

Predicted Starting Lineup: Á. Valles, F. García, M. Bartra, Natan, Á. Ortiz, M. Roca, N. Deossa, A. Ezzalzouli, Isco, Antony, T. Parrott

Feyenoord

Formation: 4-3-3

Predicted Starting Lineup: T. Ernst, J. López, M. Mármol, J. S. Juste, G. Read, O. Targhalline, G. Zechiël, C. Vanhoutte, L. Valente, N. Ferri, A. H. Moussa

Real Betis vs Feyenoord Prediction & Best Picks

Our Prediction

Our Real Betis vs Feyenoord prediction is a Betis win in a wide-open game where neither side keeps a clean sheet. The hosts get their spine back with Isco, Natan and Marc Bartra, while Feyenoord arrive short-handed. Betis are clear favorites at -150 (Polymarket) on the moneyline, and that price has landed in 7 of their last 10 games against all opponents. Feyenoord will find the net, but Betis have too much quality going forward.

Best Picks

Over 3.5 goals in the Total Goals Over/Under market. The projected total sits at 3.92 goals, clearing that line, and the implied probability on the over is close to a coin flip, which undersells a game where a Betis attack led by Isco faces a short-handed Feyenoord squad.

Yes in the Both Teams To Score market. Both sides are expected to find the net. The Both Teams To Score market fits the same read, with the projection giving both sides scoring a 71.8% probability. Betis conceded twice in each of their Champions League wins, so Ferri and the Feyenoord front three have a real path to goal.

Real Betis vs Feyenoord Same Game Parlay

Our Real Betis vs Feyenoord Same Game Parlay picks stack Betis on the moneyline, Troy Parrott as an Anytime Goalscorer, Both Teams To Score and Facundo Bernal to be shown a card.

Betis on the moneyline is the anchor. They are perfect in the Champions League so far and face a Feyenoord squad stretched thin by injuries.

Troy Parrott gets the nod up top in place of Cucho Hernandez. With Isco and Antony feeding him, the Anytime Goalscorer leg rides on the hosts' attack.

Both Teams To Score suits this matchup. Feyenoord scored three against Como, and a Betis defense that got carved open by Barcelona hardly screams clean sheet.

Bernal was sent off against Barcelona in La Liga and is available again. He isn't in the probable XI, which makes this the boldest leg, but his edge is hard to ignore.

Make sure to get the best odds on your Same Game Parlay with Oddschecker's Exclusive Same Game Parlay Comparison Tool.

Same Game Parlay odds correct at time of publishing.

Real Betis vs Feyenoord Talking Points

The big question is how fast Betis shake off the Barcelona mess now that the regulars are back. Isco pulling the strings behind Parrott, with Antony and Ezzalzouli wide, is a different animal from the rotated group that got embarrassed on Saturday. For Feyenoord, trips to Spain have been rough: they have won three of 12 European away games there. Add a lengthy injury list and Feyenoord have a lot to solve in Seville.

Real Betis vs Feyenoord Predictions FAQs

What time does Real Betis vs Feyenoord kick off?

The Champions League game kicks off at 3:00 PM ET / 12:00 PM PT on Wednesday, October 21, 2026.

Where is Real Betis vs Feyenoord being played?

The game is being played at Estadio La Cartuja de Sevilla.

Who is in the probable lineups for Real Betis vs Feyenoord?

Real Betis are projected in a 4-2-3-1 with Á. Valles, F. García, M. Bartra, Natan, Á. Ortiz, M. Roca, N. Deossa, A. Ezzalzouli, Isco, Antony and T. Parrott. Feyenoord are projected in a 4-3-3 with T. Ernst, J. López, M. Mármol, J. S. Juste, G. Read, O. Targhalline, G. Zechiël, C. Vanhoutte, L. Valente, N. Ferri and A. H. Moussa.

Where can I watch Real Betis vs Feyenoord?

The listed broadcaster for the game is TNT Sport Extra in the UK.

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