TSG Hoffenheim vs Lyon Lineups, Prediction, Betting Picks & Odds

TSG Hoffenheim vs Lyon Game Preview

TSG Hoffenheim host Lyon at the SNP Arena in a Europa League matchup where the standings and the betting market disagree. Our TSG Hoffenheim vs Lyon prediction sides with the market.

Hoffenheim opened their Europa League campaign with losses to OFI Crete and Beşiktaş. A win over Borussia Mönchengladbach last weekend finally ended a four-game losing streak in all competitions.

Lyon arrive eighth in the standings after beating Anderlecht and Crystal Palace. Paulo Fonseca's side have lost only once across their last nine competitive games, so nothing about this trip is soft.

These sides have split the points evenly in their recent meetings, with goals flowing at both ends each time. With the hosts leaking goals at the back, expect another open, messy night.

TSG Hoffenheim vs Lyon Recent Results

Hoffenheim's Europa League start has been ugly. A home loss to Beşiktaş left them without a point, and they have already given up five goals in the competition. At home in the league, a win over Borussia Mönchengladbach stopped the bleeding. Fisnik Asllani is the spark, scoring against Beşiktaş and contributing directly to a second-half goal in each of the last two home games.

Lyon are rolling. A win over Crystal Palace in their last Europa League outing, with Corentin Tolisso and Ernest Nuamah on the scoresheet, kept their record perfect, while a win over Nice has them near the top of the Ligue 1 standings. On the road, they have lost only two of their last 19 Europa League away games.

TSG Hoffenheim vs Lyon Lineups & Team News

Injuries & Suspensions

TSG Hoffenheim: Albian Hajdari (Injured/out), Patrick Wimmer (Injured/out), Nathan De Cat (Injured/out)

Lyon: Loïs Openda (Injured/out), Mohamed Ouédraogo (Injured/out), Nicolás Tagliafico (Injured/out)

TSG Hoffenheim

Christian Ilzer is without Nathan De Cat, Albian Hajdari and Patrick Wimmer, but the core of this team is intact. Oliver Baumann is in line to start in goal in our probable TSG Hoffenheim vs Lyon lineups. The creative burden falls on Andrej Kramaric, who will look to find space between Lyon's midfield and defense, with Fisnik Asllani and Adam Hlozek leading the attack.

Lyon

Paulo Fonseca is without Nicolás Tagliafico, Mohamed Ouédraogo and Loïs Openda, which thins his options at left-back and in attack. Corentin Tolisso remains an important presence in both phases, but the player to watch is Keito Nakamura. He leads all players in this season's Europa League for expected assists and has teed up seven shots from open play.

TSG Hoffenheim vs Lyon Predicted Lineup

TSG Hoffenheim

Formation: 4-4-2 (probable)

Predicted Starting Lineup: O. Baumann; V. Coufal, O. Kabak, K. Machida, Bernardo; A. Kramaric, W. Burger, L. Avdullahu, A. Daghim; A. Hlozek, F. Asllani (probable)

Lyon

Formation: 4-3-1-2 (probable)

Predicted Starting Lineup: D. Greif; Z. Athekame, F. Bacher, R. Kluivert, A. Vinícius; C. Tolisso, T. Morton, N. Nartey; K. Merah; K. Nakamura, E. Nuamah (probable)

TSG Hoffenheim vs Lyon Prediction & Best Picks

Our Prediction

Our prediction is a Hoffenheim win in a game with goals at both ends. The projection makes the hosts favorites with a 45.11% win probability. The market agrees, pricing Hoffenheim at +105 (Polymarket) on the moneyline. Lyon's form is the real deal, but a Hoffenheim attack with Andrej Kramaric pulling the strings and Fisnik Asllani finishing is built to hurt visitors at the SNP Arena. That view drives our TSG Hoffenheim vs Lyon best picks.

Best Picks

Over 2.5 in the Total Goals Over/Under market. The model projects a high-scoring game. This one sits in the Total Goals Over/Under market, and it is the cleanest read on the board. The projection lands at 3.37 total goals, and both sides found the net at a high clip the last time out, with Hoffenheim's leaky back line only adding to the case for goals.

TSG Hoffenheim to win in the Moneyline market. They are the model's favorites at home. This is a Moneyline play, and home field matters here. The projection has Hoffenheim about a third of a goal better than Lyon. The visitors also travel without Loïs Openda, Nicolás Tagliafico and Mohamed Ouédraogo, which is a lot of missing quality for a team trying to protect a perfect record.

TSG Hoffenheim vs Lyon Same Game Parlay

Our TSG Hoffenheim vs Lyon same game parlay picks stack a Hoffenheim win with Andrej Kramaric to score anytime, Both Teams To Score and Ozan Kabak to be shown a card.

Hoffenheim on the Moneyline anchors the parlay. The hosts carry the higher win probability in the projection, and their price has shortened since the open.

Kramaric in the Anytime Goalscorer market makes sense. He remains one of Hoffenheim's most important creative players, and he will be hunting space between Lyon's midfield and defense.

Both Teams To Score is the natural partner. The projection rates both sides scoring at 65.92%, and both teams have scored in seven of Hoffenheim's last eight games.

Ozan Kabak rounds it out in the To Be Shown A Card market. The center back faces a Lyon attack fed by Keito Nakamura, and the projection gives Kabak a 31.84% probability of a card.

Make sure to get the best odds on your Same Game Parlay with Oddschecker's Exclusive Same Game Parlay Comparison Tool.

Same Game Parlay odds correct at time of publishing.

TSG Hoffenheim vs Lyon Talking Points

The TSG Hoffenheim vs Lyon betting odds have moved with purpose, and the market's goals line has climbed since the open. That fits the history between these two clubs, which has produced plenty of goals and an even split of results. Christian Ilzer is not underselling the visitors either, calling Lyon "extremely dangerous" because of their tactical flexibility and transition play. He is right to respect a team with that kind of road record, but the home attack is the edge here, and we expect Kramaric and Asllani to give Lyon's back line a long night.

TSG Hoffenheim vs Lyon Predictions FAQs

What are the probable lineups for TSG Hoffenheim vs Lyon?

Hoffenheim's probable XI is O. Baumann, Bernardo, K. Machida, O. Kabak, V. Coufal, A. Daghim, L. Avdullahu, W. Burger, A. Kramaric, A. Hlozek and F. Asllani. Lyon's probable XI is D. Greif, A. Vinícius, R. Kluivert, F. Bacher, Z. Athekame, C. Tolisso, T. Morton, N. Nartey, K. Merah, K. Nakamura and E. Nuamah.

What recent form do the teams bring into TSG Hoffenheim vs Lyon?

Lyon have lost only once in their last nine competitive games. Hoffenheim have conceded five goals in their opening two Europa League games and beat Borussia Mönchengladbach 2-1 last weekend.

When is the TSG Hoffenheim vs Lyon Europa League game?

The game is on Thursday, October 22, 2026, with kickoff at 3:00 PM ET / 12:00 PM PT.

Where can I watch TSG Hoffenheim vs Lyon?

TNT Sport Extra is the listed TV channel for this game in the UK.

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