Napoli vs Roma Lineups, Prediction, Betting Picks & Odds

Napoli vs Roma Game Preview

Napoli host Roma in a Serie A matchup that carries plenty of intrigue, with the visitors arriving as the sharper side on paper heading into kickoff at the Maradona.

Napoli arrive bruised after a defeat at Venezia, their third loss of the Serie A campaign. The home crowd will want a response, and they will want it early.

Roma are flying under Gasperini, unbeaten in the league and third in the standings. Their haul from the opening weeks is their best start to a Serie A campaign since 2014/15.

History backs the hosts on their own field. Napoli are unbeaten in their last eight home games against Roma in all competitions, which shapes any Napoli vs Roma prediction.

Napoli vs Roma Recent Results

Napoli's Serie A campaign has stalled. They have already lost more league games at this stage than in any top-flight season since 2009/10. The Champions League has been kinder, with McTominay striking twice in a thrilling win over Bodø/Glimt. Højlund leads the line, but keeping opponents quiet is still a real weakness.

Roma beat Genoa last weekend to stay within touching distance of the summit, then kept rolling in Europe with a 4-0 Champions League rout of Slovan Bratislava. The unbeaten run now stretches to 14 domestic outings. Soulé is the creative hub, and Malen brings the shot volume up front.

Napoli vs Roma Lineups & Team News

Injuries & Suspensions

Napoli: Alisson Santos (Injured/out), D. Neres (Injured/out), A. Buongiorno (Injured/out), A. Vergara (Injured/out), C. Favasuli (Injured/out)

Roma: P. Dybala (Injured/out), M. Koné (Injured/out), L. Pellegrini (Injured/out), M. Svilar (Injured/out)

Napoli

Allegri is set to go with a 3-4-2-1. Meret keeps his place behind Beukema, Rrahmani and Badiashile, with Marín rested. Lobotka and Gilmour form the midfield pivot, which leaves De Bruyne and Anguissa on the bench. Di Lorenzo and Spinazzola provide the width, and Giovane could start alongside McTominay behind Højlund.

Roma

The Napoli vs Roma lineups should mirror each other, with Gasperini expected to match the 3-4-2-1 despite a selection crisis. Gollini starts in goal, and Mancini and Ndicka return alongside Hermoso. Cristante is expected to recover in time to partner De Roon. Lulli and Molina are in a toss-up at right wing back, with Wesley on the left. Pisilli pushes higher next to Soulé, and the latest news has Malen leading the line.

Napoli vs Roma Predicted Lineup

Napoli

Formation: 3-4-2-1 (probable)

Predicted Starting Lineup: Probable XI: Meret; Beukema, Rrahmani, Badiashile; Spinazzola, Lobotka, Gilmour, Di Lorenzo; McTominay, Giovane; Højlund

Roma

Formation: 3-4-2-1 (probable)

Predicted Starting Lineup: Probable XI: Gollini; Hermoso, Ndicka, Mancini; Wesley, Cristante, De Roon, Lulli; Soulé, Pisilli; Castro

Napoli vs Roma Key Stats & Game Facts

• Roma have received 2+ cards in 8 of their last 10 games against Napoli in Serie A.
• There have been 29+ shots taken in 3 of Napoli's last 3 games in Serie A.
• Matías Soulé has recorded 1+ shots on target in 5 of his last 7 appearances in Serie A.
• Marten de Roon has made 4+ tackles in 3 of his last 3 appearances against Napoli in Serie A.
• Leonardo Spinazzola has scored in 2 of his last 3 appearances against Roma in Serie A.

Napoli vs Roma Prediction & Best Picks

Our Prediction

We're calling a 2-2 tie. Roma arrive in better shape and hold a slight edge in our projections, but Napoli's attack, built on width and McTominay's late runs, has enough to hurt a Roma back line playing without Svilar in goal. The tie is +250 (Polymarket), and two creative sides trading blows is the read. Our Napoli vs Roma best picks follow the same logic.

Best Picks

Over 2.5 in the Total Goals Over/Under market. Both sides carry goals, and the model projects a high-scoring game. This one sits in the Total Goals Over/Under market. Our projections point to a high-scoring afternoon, and Roma have found the net multiple times in 11 of their last 12 Serie A outings. A Napoli defense missing Buongiorno doesn't inspire much confidence either.

Yes in the Both Teams To Score market. Both Napoli and Roma are expected to find the net. This one lives in the Both Teams To Score market. Our projections put both sides scoring at 63.25%, and that fits a game we expect to end level. Roma finish their looks well, and Napoli create plenty down the wings, so a scoreless half from either attack would be a surprise.

Napoli vs Roma Same Game Parlay

Our Napoli vs Roma same game parlay picks lean on the visitors: two Malen player props, plus Roma goals and Roma cards in a four-leg build.

Donyell Malen Over 2.5 Player Shots: he has attempted 3+ shots in 5 of his last 6 Serie A outings, and the latest news has him leading the line.

Roma Over 1.5 Total Away Goals: the Giallorossi have found the net twice or more in 6 of their past 7 domestic outings, and Napoli's crowded treatment table hits the back line.

Donyell Malen Over 0.5 Player Shots On Target: he has recorded 1+ shots on target in 5 of his last 6 Serie A outings. Volume plus accuracy is what you want.

Roma Over 1.5 Total Away Team Cards: this line has landed in each of Roma's last four games, and an aggressive side built to steal the ball will commit fouls.

Make sure to get the best odds on your Same Game Parlay with Oddschecker's Exclusive Same Game Parlay Comparison Tool.

Same Game Parlay odds correct at time of publishing.

Napoli vs Roma Talking Points

The pressure on Allegri is the storyline. Napoli's points haul at this stage is their lowest in 17 years, and losing at home to a Roma side unbeaten in the league would only sharpen the questions. Roma's concern is personnel. With so many senior pieces sidelined, Gasperini needs Soulé and Pisilli to carry the creative load. Neither coach can afford a cagey afternoon, so expect a messy, open game in Naples.

Napoli vs Roma Predictions FAQs

When is the Napoli vs Roma Italian Serie A game?

The game kicks off at 12:00 PM ET / 9:00 AM PT on Saturday, October 24, 2026, in the 2026/2027 Serie A season.

Where is Napoli vs Roma being played?

The game is being played at Diego Armando Maradona.

Where can I watch Napoli vs Roma?

Broadcast listings for the game include ESPN and TNT Sports 4.

Who is expected to start for Napoli and Roma?

Napoli's probable lineup has Meret in goal and Højlund up front, while Roma's has Gollini in goal and Castro as the forward. Both sides are listed in a 3-4-2-1 formation.

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