Daniil Medvedev vs. Frances Tiafoe Prediction, Betting Pick, Latest US Open Odds for Sunday, September 6th
Daniil Medvedev and Frances Tiafoe meet in the fourth round of the US Open on Sunday, September 6. Both players arrive after impressive straight-sets victories as a place in the quarterfinals awaits in New York.
Peter Alexis - September 6, 2026, 1:00 PM EDT
4 Minute ReadDaniil Medvedev vs. Frances Tiafoe Prediction: Can Medvedev Continue Dominant Series Over Tiafoe on Sunday in US Open Round of 16?
Daniil Medvedev faces Frances Tiafoe at Louis Armstrong Stadium on Sunday, with their fourth-round matchup scheduled for 3:00 PM ET. The 2021 champion is a -165 moneyline favorite against the +130 American, who will have a vocal home crowd behind him in one of the afternoon’s biggest matches.
Medvedev has been outstanding through three rounds, winning all nine sets without needing a tiebreak. He defeated Hugo Gaston 6-4, 6-2, 6-4 and Sebastian Gorzny 6-1, 6-3, 7-5 before dispatching Arthur Rinderknech 6-4, 6-4, 6-4. Against Rinderknech, he recovered from an early 4-2 deficit and then avoided facing a break point throughout the second set.
Daniil Medvedev vs. Frances Tiafoe Odds
- Moneyline: Medvedev (-160), Tiafoe (+140)
Daniil Medvedev vs. Frances Tiafoe Date, Time, and Where to Watch
- Date: Sunday, September 6th, 2026
- Time: 3:00 PM ET
- Where to Watch: ESPN2
Click here for complete Daniil Medvedev vs. Frances Tiafoe Odds
Daniil Medvedev vs. Frances Tiafoe Prediction
Tiafoe has also raised his level after needing five sets against Martin Damm in the opening round. He followed that escape with straight-sets victories over Rei Sakamoto and Valentin Vacherot, beating the latter 6-4, 6-2, 6-4. Tiafoe was not broken against Vacherot and finished with 30 winners against only 13 unforced errors, making this a meaningful test of Medvedev’s current form.
The rivalry still points strongly toward Medvedev. He leads the ATP head-to-head 6-1 and won their latest meeting 6-3, 6-2 in Brisbane in January. Their previous US Open encounter was even more decisive, with Medvedev winning 6-4, 6-1, 6-0 in the fourth round in 2020. He also beat Tiafoe in four sets at that year’s Australian Open, giving the set-spread selection support from both previous Grand Slam meetings.
Medvedev’s deep returning position and ability to absorb pace have repeatedly complicated Tiafoe’s attacking game. The American wants to establish control quickly and finish points before getting pulled into prolonged exchanges, but Medvedev makes him hit additional shots from uncomfortable positions. Tiafoe’s recent serving is a concern for the favorite, although maintaining those numbers against this caliber of returner is a substantially harder assignment.
Daniil Medvedev vs. Frances Tiafoe Best Bet
- Best Bet: Medvedev -1.5 Sets (-110) Check out the best odds at DraftKings Sportsbook
The -1.5-set spread at +110 provides room for Tiafoe to capture one set without requiring another Medvedev sweep. A 3-0 or 3-1 victory cashes, matching the outcomes of their previous major meetings. With nine consecutive sets won in New York and another convincing head-to-head victory already secured this season, Medvedev has the consistency and matchup advantage to finish this inside five sets.
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