Oklahoma State vs. Iowa State Prediction, Betting Pick, Latest CFB Odds for Saturday, October 31st
No. 24 Oklahoma State travels to Ames for a Saturday night Big 12 showdown against Iowa State, with the Cowboys looking to strengthen their conference championship hopes against a Cyclones team struggling to generate consistent offense. Can Drew Mestemaker and Oklahoma State's explosive passing attack capitalize on Iowa State's recent defensive struggles while containing Aiden Flora and the Cyclones' rushing game? Check out this Oklahoma State vs. Iowa State prediction and best bet for Saturday, October 31.
Peter Alexis
October 31, 2026, 6:00 PM EDT