Sassuolo vs Lazio prediction, probable lineups and bet builder tips. Explore the odds and standout bets ahead of Tuesday's Serie A clash in Italy.
Sassuolo vs Lazio Match Summary
Competition | Italian Serie A |
|---|---|
Match Date | Tuesday 27 October 2026 |
Match Time | 17:30 UK time |
Venue (City, Stadium) | MAPEI Stadium - Città del Tricolore |
Sassuolo vs Lazio pits a side in freefall against one of the form teams in Serie A, and the gulf looks wide heading into Tuesday's kick-off at the MAPEI Stadium.
Sassuolo sit 14th and have stalled badly since a bright start that featured a September win over Juventus. They are now winless in four league outings and leaking goals.
Lazio arrive second in the table under Gennaro Gattuso. It is the club's best start to a Serie A season since their 1999-00 Scudetto-winning campaign.
Lazio have won four of the six previous meetings, against one Sassuolo win and one draw. Add the gap in the table and any Sassuolo vs Lazio prediction points one way.
Sassuolo vs Lazio Form
Sassuolo have taken a single point from the last 12 available in Serie A, and the defence is the obvious problem. They have conceded at least two goals in five of their last six league matches. Vasilije Adzic remains their brightest spark in the engine room, regularly chipping in with goals and assists when little else is working.
Lazio have won 8 of their last 9 matches in Serie A, and they are not scraping by. There have been over 2.5 goals in 5 of Lazio's last 6 league games, with Mattia Zaccagni the standout threat from the left and Gustav Isaksen giving them a direct outlet on the other side.
Sassuolo vs Lazio Lineups & Team News
Injuries & Suspensions
Sassuolo: Fedde Leysen (Injured/out), Ismaël Koné (Injured/out), Jay Idzes (Injured/out), Daniel Boloca (Injured/out)
Lazio: Albert Gudmundsson (Injured/out), Adam Marusic (Injured/out), Andrea Pinamonti (Injured/out)
Sassuolo
On the Sassuolo vs Lazio lineups, Alberto Aquilani is set to go with a probable 4-3-3, with Arijanet Muric in goal and Nemanja Matic anchoring the engine room alongside Kristian Thorstvedt and Vasilije Adzic. Domenico Berardi and Armand Laurienté should flank Sebastiano Esposito up top. Four injuries bite, with Fedde Leysen, Ismaël Koné, Jay Idzes and Daniel Boloca all unavailable.
Lazio
Gennaro Gattuso's probable XI is his settled 4-3-3, built around Christos Mandas in goal and Oliver Provstgaard and Josip Sutalo at centre-back. Davide Frattesi, Reda Belahyane and Kenneth Taylor make up the midfield, with Mattia Zaccagni and Gustav Isaksen supporting Tijjani Noslin. Albert Gudmundsson, Adam Marusic and Andrea Pinamonti are all ruled out injured.
Sassuolo vs Lazio Predicted Lineup
Sassuolo
Formation: 4-3-3
Predicted Starting Lineup: Probable XI: Muric; Cinquegrano, Odenthal, Caleta-Car, Doig; Thorstvedt, Matic, Adzic; Berardi, Esposito, Laurienté
Lazio
Formation: 4-3-3
Predicted Starting Lineup: Probable XI: Mandas; Mussolini, Provstgaard, Sutalo, Tavares; Frattesi, Belahyane, Taylor; Isaksen, Noslin, Zaccagni
Check out all the latest oddschecker Free Bets & Sign-Up Offers for Sassuolo vs Lazio.
Sassuolo vs Lazio Key Stats & Match Facts
Lazio have scored 2+ goals in 5 out of 7 matches against Sassuolo in Serie A.
Lazio have had 5+ shots on target in 4 out of 5 matches against Sassuolo in Serie A.
Domenico Berardi has attempted 3+ shots in 4 of his last 6 appearances against Lazio in Serie A.
There have been 10+ shots on target in 7 of Sassuolo's last 8 matches in Serie A.
There have been 6+ cards in 4 of the last 6 meetings between Lazio and Sassuolo in Serie A.
Sassuolo vs Lazio Prediction & Best Bets
Our prediction: Sassuolo 1-2 Lazio. The visitors are the better side in every department that matters, and the away win carries a strong implied probability in the Sassuolo vs Lazio betting odds. Sassuolo have enough going forward to nick a goal, but Lazio have the quality to take the points.
Best Bets
Lazio to win at Sassuolo in the Win Market. This heads our Sassuolo vs Lazio best bets. Lazio carry a 52% Oddschecker AI implied probability, and the away win has been flagged as 4-star value at several bookmakers, which tells you the market has not fully caught up with the gulf in the table.
Both teams to score: Yes, in the Both Teams To Score market. Both teams to score carries a 62.7% implied probability in our numbers, with Sassuolo projected for 1.32 goals. Lazio's attack will do its part, and a home side with Berardi and Adzic in the side can find a way through even when the defence keeps letting them down.
Sassuolo vs Lazio Bet Builder
Our Sassuolo vs Lazio bet builder tips lean into Lazio's attack: the visitors to score at least twice, Mattia Zaccagni to be busy in front of goal, and Vasilije Adzic to score anytime.
Lazio Over 1.5 Total Away Goals. They have scored 2+ goals in 6 of their last 6 Serie A matches, and Sassuolo's leaky back line gives little reason to expect a quiet night.
Mattia Zaccagni Over 2.5 Player Shots. The winger gets at goal regularly, having attempted 3+ shots in 6 of his last 8 league outings, and Sassuolo struggle to defend attacks down the wings.
Vasilije Adzic Anytime Goalscorer. The midfielder has found the net three times across his last five top-flight games, making him Sassuolo's most obvious route to a goal of their own.
Mattia Zaccagni Over 0.5 Player Shots On Target. He has tested the keeper in five of his previous six Serie A outings, a sensible partner for his shots leg.
At the time of writing, this bet builder pays a best price of 17/1 and is as short as 11/1 elsewhere.
Make sure to get the best odds on your Bet Builder with Oddschecker's Exclusive Bet Builder Comparison Tool.
Bet builder odds correct at time of publishing.
Sassuolo vs Lazio Talking Points
The big question is whether Sassuolo can lay a glove on the meanest defence in the division. Lazio have conceded just five league goals, the tightest record in Serie A, and have not shipped a first-half goal in any of their eight league matches this term. Sassuolo's best routes are counter-attacks and set pieces, where direct free kicks are a genuine strength, and that is where Berardi and Laurienté come in. At the other end, Sassuolo are vulnerable to attacks down the wings, which is exactly where Lazio like to hurt teams through Zaccagni and Isaksen. Expect the visitors to keep it stubborn early and do their real damage after the break.
Sassuolo vs Lazio Predictions FAQs
When is the Sassuolo vs Lazio Italian Serie A game?
The match is on Tuesday 27 October 2026 at 17:30 UK time.
Where is Sassuolo vs Lazio being played?
The match is being played at MAPEI Stadium - Città del Tricolore.
What competition is Sassuolo vs Lazio in?
Sassuolo vs Lazio is a Serie A match in the 2026/2027 season.
Disclaimer
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