Northern Arizona Lumberjacks at Montana State Bobcats

The Wake Forest Demon Deacons head back on the road for an ACC matchup against No. 16 Louisville after hanging around with Miami deep into the fourth quarter. Can Gio Lopez and the Demon Deacons create enough explosive offense to stay within two touchdowns against a Cardinals team coming off a ranked victory over SMU? Check out this Wake Forest vs. Louisville prediction and best bet for Saturday, September 26.

The No. 1 Texas Longhorns open SEC play with their first true road test of the season against No. 14 Tennessee in one of the biggest games of Week 4 at Neyland Stadium. Can Faizon Brandon, Daune Morris and the Volunteers take advantage of a Texas offense that looked vulnerable against UTSA while feeding off one of the toughest home environments in college football? Check out this Texas vs. Tennessee prediction and best bet for Saturday, September 26.

The Clemson Tigers make their first West Coast conference trip for a Friday night ACC matchup against California at Memorial Stadium. Can Tait Reynolds and Clemson's improving rushing attack handle the cross-country setting against Jaron-Keawe Sagapolutele and a Cal defense that has been creating turnovers at one of the highest rates in the country? Check out this Clemson vs. California prediction and best bet for Friday, September 25.

The Northwestern Wildcats take their unbeaten start into Bloomington for a Friday night Big Ten opener against defending national champion No. 5 Indiana. Can Aidan Chiles and Chip Kelly's rebuilt offense carry the momentum from a dominant win over Colorado into its first road test against Josh Hoover and an Indiana defense coming off consecutive shutouts? Check out this Northwestern vs. Indiana prediction and best bet for Friday, September 25.

The Navy Midshipmen return from an open week for a Friday night American Conference road matchup against UAB at Protective Stadium. Can Braxton Woodson and one of the nation's most productive rushing attacks maintain Navy's recent dominance of the series against a Blazers team that has been much tougher at home? Check out this Navy vs. UAB prediction and best bet for Friday, September 25.

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