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The Mississippi State Bulldogs take one of the strongest starts of the young season into Columbia for their SEC opener against an unbeaten South Carolina team. Can Kamario Taylor build on his breakout performance at Minnesota against LaNorris Sellers and a Gamecocks defense that has allowed only nine points through two games? Check out this Mississippi State vs. South Carolina prediction and best bet for Saturday, September 19.

The No. 16 SMU Mustangs head to Louisville for a ranked ACC matchup against the No. 23 Cardinals, who are trying to reverse a series that has been completely controlled by SMU. Can Lincoln Kienholz continue his explosive start and protect home field against Kevin Jennings and a Mustangs offense that has already produced more than 1,100 yards through two games? Check out this SMU vs. Louisville prediction and best bet for Saturday, September 19.

The Florida State Seminoles travel to Tuscaloosa for a rematch with a No. 10 Alabama team they upset by two touchdowns in last season's opener. Can Ashton Daniels and Ousmane Kromah use Florida State's rushing attack and extra preparation time to keep the Seminoles competitive against Keelon Russell and the Crimson Tide at Bryant-Denny Stadium? Check out this Florida State vs. Alabama prediction and best bet for Saturday, September 19.

The Kentucky Wildcats make their first road trip of the season to face No. 9 Texas A&M at Kyle Field after showing two very different versions of themselves against Alabama. Can Kenny Minchey and a Kentucky defense with significant familiarity with Mike Elko's system keep the Wildcats within striking distance against Marcel Reed and the unbeaten Aggies? Check out this Kentucky vs. Texas A&M prediction and best bet for Saturday, September 19.

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