Parry/Horschel/Hughes

The Portland State Vikings make the short trip to Eugene for a Friday night in-state matchup against a No. 21 Oregon team coming off one of the biggest upsets of the young season. Can Dante Moore and the Ducks turn last week's stunning loss into a statement performance without Portland State contributing enough offense to push an enormous total over the number? Check out this Portland State vs. Oregon prediction and best bet for Friday, September 18.

The No. 22 Houston Cougars travel to Lubbock for a ranked Friday night Big 12 opener against the No. 13 Texas Tech Red Raiders at Galaxy Stadium. Can Conner Weigman and a much more explosive Houston offense challenge Will Hammond and the defending Big 12 champions in a matchup that has drawn significant market support toward the underdog? Check out this Houston vs. Texas Tech prediction and best bet for Friday, September 18.

The No. 5 Miami Hurricanes travel to Winston-Salem for a Friday night ACC matchup against an unbeaten Wake Forest team at Allegacy Financial Stadium. Can Gio Lopez and the Demon Deacons generate enough offense against Miami’s elite defense to challenge Darian Mensah and one of the most explosive attacks in college football? Check out this Miami vs. Wake Forest prediction and best bet for Friday, September 18.

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