UFC 321 Odds: Betting Odds for Every Fight on the UFC 321 Card
UFC 321 is headlined by Tom Aspinall's heavyweight title defense, while also getting a co-main thriller with MacKenzie Dern as a slight favorite in strawweight. Let's take a look at the complete UFC 321 betting card odds ahead of Saturday's fights in Abu Dhabi.
Peter Alexis - October 24, 2025, 11:45 PM EDT
5 Minute ReadUFC 321 Odds: Betting Odds for Every Fight on the UFC 321 Card
UFC 321 brings the action overseas to Etihad Arena in Abu Dhabi this Saturday, where an early 2 p.m. ET main card start will showcase one of the strongest fight lineups of the year. The event is headlined by interim heavyweight champion Tom Aspinall, who looks to defend his belt against former titleholder Ciryl Gane in a matchup that could determine the future of the heavyweight division. In the co-main event, grappling star Mackenzie Dern faces the relentless Virna Jandiroba in a high-stakes strawweight clash that could have major implications for the top five.
With a mix of elite grapplers, knockout artists, and rising contenders, UFC 321 has something for everyone. The card also features Umar Nurmagomedov, who will look to bounce back from his first career loss, and Jailton Almeida, one of the most dangerous submission specialists in the heavyweight division. As always, Abu Dhabi cards bring extra energy, and this one promises to deliver with championship implications across multiple divisions.
So what are the sportsbooks expecting from this loaded event? Here’s a full breakdown of the UFC 321 betting odds and fight-by-fight outlook.
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UFC 321 Date, Time, and Where to Watch
- Date: Saturday, October 25, 2025
- Time: 2:00 PM ET (Main Card)
- Where to Watch: ESPN+ PPV
Click here for complete UFC 321 odds
Tom Aspinall vs. Ciryl Gane Odds
- Moneyline: Aspinall (-370), Gane (+320)
Aspinall is heavily favored to retain his interim title, entering the bout as a -370 favorite after steamrolling his last three opponents. His speed and boxing have made him one of the most well-rounded heavyweights in the world, while Gane looks to rebound from his loss to Jon Jones and prove he still belongs at the top. Gane’s best path to victory will be through his movement and precision striking, but Aspinall’s pressure and power make him the clear pick according to oddsmakers.
Click here for complete Aspinall vs. Gane odds
Virna Jandiroba vs. Mackenzie Dern Odds
- Moneyline: Jandiroba (+128), Dern (-152)
The co-main event is a grappler’s dream. Dern’s elite jiu-jitsu has long been her calling card, but Jandiroba’s physicality and improving stand-up make this a much closer fight than the odds suggest. Dern’s path to victory lies on the mat, while Jandiroba may try to keep the fight standing and outwork her over three rounds. The line reflects the respect for Dern’s submission threat, but don’t be shocked if Jandiroba makes this a dogfight.
Click here for complete Jandiroba vs. Dern odds
Umar Nurmagomedov vs. Mario Bautista Odds
- Moneyline: Nurmagomedov (-620), Bautista (+525)
Nurmagomedov enters as one of the biggest favorites on the card, and for good reason. He’s been nearly flawless in his UFC career, combining the signature Dagestani wrestling of his family lineage with sharp striking and pace. Bautista is a capable veteran with solid boxing and defensive grappling, but Nurmagomedov’s dominance in scrambles and control time makes him a tough puzzle to solve. This fight is expected to be one-way traffic unless Bautista can land something big early.
Click here for complete Nurmagomedov vs. Bautista odds
Alexander Volkov vs. Jailton Almeida Odds
- Moneyline: Volkov (+166), Almeida (-185)
This heavyweight showdown could steal the show. Almeida has been a wrecking ball since joining the UFC, with his ground game and submission skills overwhelming nearly everyone he faces. Volkov, however, is a veteran with elite striking and massive reach who can punish mistakes from distance. If Almeida gets it to the ground, he likely cruises, but Volkov’s defensive improvements and power make him a live underdog for bettors seeking value.
Click here for complete Volkov vs. Almeida odds
Aleksandar Rakic vs. Azamat Murzakanov Odds
- Moneyline: Rakic (-110), Murzakanov (+105)
The main card opener is a near pick’em between two dangerous light heavyweights. Murzakanov’s power and explosiveness make him a constant knockout threat, while Rakic is returning from a long injury layoff and looking to reestablish himself as a top contender. Rakic’s technical striking and volume should give him an edge early, but if Murzakanov connects cleanly, it could end fast. Oddsmakers are split, and rightfully so — this fight has “Fight of the Night” potential written all over it.
Click here for complete Rakic vs. Murzakanov odds
UFC 321 Prelims - Betting Odds
Fighter 1 Odds | Fighter 2 Odds |
|---|---|
Nasrat Haqparast (-115) | Quillan Salkilld (-105) |
Ikram Aliskerov (-235) | JunYong Park (+195) |
Ludovit Klein (-150) | Mateusz Rebecki (+125) |
Abdul-Kareem Al-Selwady (-120) | Matheus Camilo (even) |
Valter Walker (-335) | Louie Sutherland (+270) |
Jose Delgado (-140) | Nathaniel Wood (+120) |
Hamdy Abdelwahab (-450) | Chris Barnett (+330) |
Azat Maksum (-400) | Mitch Raposo (+300) |
Jaqueline Amorim (-450) | Mizuki Inoue (+339) |
MMA ODDS & PICKS
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