San Francisco 49ers vs Detroit Lions Betting Preview, Odds and Prediction

Books install the Niners as more than touchdown favorites for their Week 1 season opener against the Lions on the road. Can the Niners cover the hefty point spread? Or will the Lions defy the odds?
Nikki Adams
Tue, September 7, 7:56 AM EDT

San Francisco 49ers vs Detroit Lions Betting Preview, Odds and Prediction

Date: Sunday, September 12, 2021

Time: 1:00 PM ET

Location: Ford Field, Detroit, MI

TV Network: FOX

San Francisco 49ers Record: 0-0

Detroit Lions Record: 0-0

Click here to see the latest 49ers vs Lions betting odds.

San Francisco 49ers vs. Detroit Lions Giants Betting Odds Preview

Right now, there are only two games on Sunday’s Week 1 NFL betting slate that feature a touchdown line or higher. Those games are, ironically, Niners vs. Lions and Bears vs. Rams. Two teams – the Lions and Rams – that were involved in one of the most stunning quarterback-swaps this offseason happen to be looking at opposing ends of a 7.5 point spread in the first week of the season. If that’s not an indication of which side is considered the winner of the Stafford-Goff trade, what is?

The Detroit Lions carry some of the lowest NFL futures odds and expectations of all 32 teams in the league. Buzz words and phrases such as “rebuilding” and “new era” have left only the most diehard Lions fans riding the Motown bandwagon into 2021. Thus, it’s really not surprising to see the San Francisco 49ers vs. Detroit Lions odds firmly cornered with the visitors in this week 1 NFC showdown.

San Francisco 49ers Odds & Overview

The San Francisco 49ers are coming off an injury-ridden season that plunged them into the NFC West basement only a year after finishing runners-up to the Kansas City Chiefs in Super Bowl 54. To say it was a huge let down is an understatement. Jimmy Garropolo, George Kittle, Dee Ford, Raheem Mostert, Deebo Samuel, Richard Sherman… all were amongst the walking wounded that left Kyle Shanahan with a skeleton team to work with for the better part of the season.

The Niners sent seismic shockwaves through the NFL when they moved up to No.3 in the 2021 NFL draft and selected Trey Lance. The move to draft a rookie quarterback put Garoppolo’s status with the franchise in question, prompting many to wonder whether he was even going to start in 2021. For now, that question has been temporarily put to bed as the Niners have named Garoppolo the starter for the first week of the season. Should Garoppolo struggle though in the early weeks, you can bet Trey Lance will come up again.

Detroit Lions Odds & Overview

The Detroit Lions got a quarterback that only a few years ago featured in a Super Bowl, but nobody is buying what he’s selling. It seems that Jared Goff has not only fallen out of favour with his former head coach Sean McVay, but also with bookmakers, bettors and fans alike. Talk about tough love.

Of course, Goff isn’t solely responsible for the Detroit’s dim prospects in 2021. The upheaval with the Lions organisation as a whole is largely responsible for the discouraging odds across the board. New head coach Dan Campbell is a bit of longshot, while the roster is decidedly short on talent around Goff and on the defensive side of the ball – all of which points to a long season riddled with trial and tribulation.

San Francisco 49ers vs. Detroit Lions Odds

Team Spread Moneyline
San Francisco 49ers -7.5 -333
Detroit Lions +7.5 +300

Click here to see the latest 49ers vs Lions betting odds.

San Francisco 49ers vs. Detroit Lions Prediction and Betting Preview

Jared Goff has many doubters, but a rebuilding team doesn’t provide an ideal situation to prove those doubters wrong. He’s really in a tough spot. Made tougher for the fact that his first game with a new team pits him against a defense that has given him nightmares before. One fears for Goff in this game.

Jimmy G. has his fair share of critics too. So, he too will be eager to put paid on those as he leads the Niners in week 1 against the Lions. Unlike his Lions counterpart, Garoppolo is surrounded by talent in all three facets of the game. The Niners run offense is something to behold, the pass game has elite weapons and the defense is at another level.

Betting San Francisco 49ers vs. Detroit Lions Odds is a bit tricky considering the line is rather hefty. Against most teams, a touchdown line or higher can feel like a lot of points to cover. However, against the hapless Lions, it doesn’t seem problematic at all. Expect Kyle Shanahan to dial up some smart plays that will rack up the points in a hurry and, at the same time, the Niners defense wreak havoc and stall Goff and the Lions offense.

NFL Pick: Niners -7.5

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