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Arizona Cardinals vs. Carolina Panthers NFL Week 10 Betting Odds, Picks, and Preview

Arizona Cardinals vs. Carolina Panthers NFL Week 10 odds, betting picks, and game preview ahead of their game on Sunday. Oddsmakers lean towards it being one-sided but Nikki Adams is here with the full preview.
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Arizona Cardinals vs. Carolina Panthers NFL Week 10 Betting Odds, Picks, and Preview

The Carolina Panthers were one of two teams to make a big splash this week, bringing back Cam Newton as their starter for the remainder of the season. However, the former No.1 draft pick isn’t expected to start against the Arizona Cardinals Sunday. That nod has already gone to P.J. Walker, resulting in the lopsided NFL betting market as the Panthers square up to the best team in the NFC, the Arizona Cardinals.

Carolina Panthers (4-5-0, 4-5-0 ATS) vs Arizona Cardinals (8-1-0, 7-2-0 ATS)

Date: Sunday, November 14, 2021

Start Time: 4:05 PM ET

Location: State Farm Stadium, Glendale

TV Coverage: FOX

Click Here For Cardinals vs. Panthers Odds

Carolina Panthers Betting Preview

Carolina’s 3-0 start to the season seems like a lifetime ago now. Since then, the Panthers have gone 1-5 straight up and ATS. The lone bright spot was a 19-13 win over the Atlanta Falcons in Week 8.

Last Sunday, the Panthers lost to the Patriots 24-6, failing to even whiff at the closing 3.5-point spread. Accompanying the defeat was yet another dismal offensive performance and a slew of injuries for Carolina. Not even Christian McCaffrey’s return was able to spark Carolina’s anaemic offense into action, despite his best efforts. The fifth-year running back lead the team in both rushing and receiving scampering, for 52 yards on 14 carries and 54 yards on four receptions.

Darnold’s return from a concussion was disappointing, to put it mildly. Whether he was experiencing a déjà vu seeing-ghosts moment against the Patriots, only he would know. From an onlooker’s perspective, though, the three interceptions he threw felt eerily familiar.

Matt Rhule didn’t bench Darnold this time, although few would have found fault with such a decision had he made it. After the game, Carolina revealed that Darnold would be out for several weeks with a shoulder injury, which was likely the cause of those errant throws.

Arizona Cardinals Betting Preview

Kyler Murray and De’Andre Hopkins sat out of last week’s clash with the San Francisco 49ers, but despite their absence, Kliff Kingsbury’s side romped to the 31-17 win over their NFC West rivals. Colt McCoy was in charge of the offense.

Having an able backup quarterback is a luxury not many teams have, but following last Sunday’s win, the Cardinals know they’re one of the lucky ones. On the other hand, it does raise some questions about Arizona’s success this season. Is it the work of Kyler Murray – one of the short-odds on favorites to win the MVP this season? Or is it the combination of great coaching and team ethos?

Whatever it is, it’s working. The Cardinals are 8-1 on the season and in pole position in the NFC West and the NFC standings. If the regular season ended today, they’d be the No.1 seed in the NFC.

Cardinals vs. Panthers Week 10 Odds

TeamMoneylineML Implied Win ProbabilitySpreadTotal
Panthers+40020%+10 (+100)O 44 (-110)
Cardinals-45582%-10 (-110)U 44 (+102)

Click Here For Cardinals vs. Panthers Odds

Markets went to press with the Cardinals as the 9.5-point favorites, but the line quickly adjusted to 10 points as the public bet up Arizona. A few occasions of Arizona -10.5 popped up during the week, but the market, for the most part, appears to be settling on 10 points. The total opened on 44.5 points but jumped out to 45 points soon thereafter.

Cardinals vs. Panthers Betting Predictions and Picks

Under most circumstances, a double-digit point spread warrants careful consideration before settling on either side of the coin. In this case, it feels like a no-brainer. The Panthers can’t seem to buy a win no matter how hard they try. They’re turning to a backup quarterback that hasn’t impressed the few times he’s been on the field already. And he’s not getting much help from a hobbled and injury-riddled offensive line anyway.

Kyler Murray and De’Andre Hopkins are expected to return this Sunday. But, even if one or the other doesn’t, the Cardinals have shown they’re more than capable of keeping the momentum going. As such, betting Arizona to win at home is the best option.

It’s hard to find a line lower than Arizona -10 at the moment, and while the line could dip below that number later in the week, there’s no guarantee it will happen. The line could continue swelling instead. So, you could play the waiting game or grab the 10 points while you still can.

Keep in mind, the Panthers lost to the Giants (of all teams) 25-3, and then to the Patriots 24-6. Oh, and the Cardinals are 7-2-0 ATS with a 13.6 winning margin on average. You could say a 10-point victory is in their wheelhouse.

Cardinals vs. Panthers Betting Picks: Cardinals -10


Nikki Adams is a freelance sports writer that’s honed in on the world of sports betting. She joined OddsChecker in 2021 after having covered a number of major American sports, including NFL and NCAAF, for several other publications in the industry. When she’s not looking for the best betting angles and writing engaging and insightful articles, she’s likely on a tennis court or binging on reality TV.


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