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The Cleveland Browns and Jacksonville Jaguars open the season with very different expectations after Jacksonville won 13 games and Cleveland finished near the bottom of the AFC. Deshaun Watson returns after a long absence for a Browns offense featuring an entirely rebuilt offensive line, while Trevor Lawrence leads the defending AFC South champions. Check out this Browns vs. Jaguars prediction and best bet for Sunday, September 13.

The Chicago Bears and Carolina Panthers begin the season in a matchup of 2025 NFC division champions. Caleb Williams is entering his second season in Ben Johnson's offense after a breakout year, while Bryce Young and Tetairoa McMillan try to build on Carolina's return to the playoffs. Check out this Bears vs. Panthers prediction and best bet for Sunday, September 13.

The New Orleans Saints and Detroit Lions open 2026 indoors at Ford Field with a total approaching 50 points. Tyler Shough looks to build on a promising finish to last season for New Orleans, while Jared Goff and Detroit return one of the league's deeper collections of offensive playmakers. Check out this Saints vs. Lions prediction and best bet for Sunday, September 13.

Read our Chicago Fire vs New England Revolution prediction with the latest odds, projected lineups, and top betting picks for Sunday's huge MLS game.

The New York Jets and Tennessee Titans begin the season after matching 3-14 records in 2025, but both teams made substantial changes during the offseason. Geno Smith now leads the Jets, while second-year quarterback Cam Ward enters a new offensive structure under Brian Daboll in Tennessee. Check out this Jets vs. Titans prediction and best bet for Sunday, September 13.