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San Francisco 49ers vs. Arizona Cardinals MNF Odds: 76% of Bets on 49ers to Beat Cardinals in Mexico City

San Francisco 49ers vs. Arizona Cardinals Monday Night Football odds and betting breakdown. This week on Monday Night Football, we have an NFC West showdown between the 49ers and Cardinals. Find out who you should be betting on here.
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San Francisco 49ers vs. Arizona Cardinals MNF Odds: 76% of Bets on 49ers to Beat Cardinals in Mexico City

Monday Night Football is sure to be a good one this week as we get a rivalry game between the San Francisco 49ers and Arizona Cardinals. If you're a betting person, you're here to check out 49ers vs. Cardinals odds and see who you should be backing, and you've come to the right place.

The San Francisco 49ers have Super Bowl aspirations this NFL season, despite the fact that they lost the face of their franchise moving forward in Trey Lance. Led by their defense, San Fran hoped to be atop the NFC by now, but bad losses to teams like the Bears, Broncos and Falcons have haunted them.

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As for the Cardinals, It's been an equally disappointing season as they come into this week at 4-5. There have been rumblings about the happiness of franchise QB Kyler Murray, as well as questions about his dedication, and fans are wondering if Kliff Kingsbury will be there much longer.

So, what do the San Francisco 49ers vs. Arizona Cardinals odds tell us for this Monday Night Football game? Not only are the 49ers heavy favorites, but they're also heavily backed by the betting public.

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San Francisco 49ers vs. Arizona Cardinals - Monday Night Football Odds

TeamML OddsML Betting %Point Spread
San Francisco 49ers-35076%-8
Arizona Cardinals+30024%+8

Click here to get the latest 49ers vs. Arizona Cardinals odds

49ers vs. Cardinals odds paint an ugly picture for the Cardinals, but it's the public betting data that is even more lopsided and may be a sign of things to come.

The San Francisco 49ers are a whopping 8-point favorites over their division rival on Monday night football, but it actually makes sense. Kyler Murray is questionable for Monday Night Football, and while this game is technically a "home" game for the Cardinals, it's being played in Mexico City.

Above, you can see that 76% of the moneyline bets placed on this game at DraftKings are backing the 49ers to win outright. Just 24% are behind the Cardinals to pull off the upset.

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Brian is a sports journalist with close to ten years of experience in the business. A lifelong Philadelphia sports fan with a passion for all things sports gambling.

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