Houston vs. Oregon State Prediction, Betting Pick, Latest CFB Odds for Friday, September 26th
The Oregon State Beavers will try to snap their early season losing streak and find their first win of the season on Friday night. Can Maalik Murphy and the Beavers compete with Connor Weigman and the Houston Cougars tonight in Corvallis? Let's take a look at our Houston vs. Oregon State prediction for Friday, September 26th.
OC Staff - September 26, 2025, 3:55 PM EDT
5 Minute ReadHouston vs. Oregon State Prediction: Can Conner Weigman, Cougars Stay Undefeated Against Winless Beavers?
The Houston Cougars are off to a perfect 3-0 start under new quarterback Conner Weigman, a Texas A&M transfer who has quickly given the offense a spark. Houston hasn’t just been winning — they’ve been winning big, with all three victories coming by double digits. Their most impressive result came last week when they dismantled Deion Sanders’ Colorado squad, firmly cementing themselves as a team to watch in the Big 12 race. Oddsmakers have taken notice, installing Houston as a sizable -13.5 road favorite on Friday night.
Oregon State, meanwhile, is searching for its first win of the season. The Beavers were humbled last weekend in a rivalry blowout against Oregon, with quarterback Maalik Murphy struggling to just 5 completions on 18 attempts for 68 yards. Still, Murphy has flashed potential since arriving in Corvallis after stops at Texas and Duke. He’s already closing in on 1,000 yards with six touchdowns, but his five interceptions highlight the inconsistency that has plagued this offense. Pair that with a defense that has surrendered 34+ points in every game, and it’s been a rough September for Trent Bray's team.
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Houston vs. Oregon State Odds
Houston vs. Oregon State Date, Time, and Where to Watch
- Date: Friday, September 26, 2025
- Time: 10:30 PM ET
- Where to Watch: ESPN
Click here for complete Houston vs. Oregon State odds
Houston vs. Oregon State Prediction
Looking at the spread, Houston’s early dominance may have inflated the number. Laying nearly two touchdowns on the road is no small ask, especially against a Beavers team that has shown offensive life outside of last week’s Oregon debacle. Our oddschecker+ Positive EV Tool make this line closer to -10.5, signaling value on Oregon State +13.5 with 7.25% +EV. The Beavers may not be good enough to pull the upset, but in a bounce-back spot at home, they could keep this within striking distance.
Another angle to consider is the total. At 47.5, the market is pricing this game as a grind, but the numbers don’t entirely back that up. With two veteran quarterbacks and shaky defenses — Houston’s pass defense is still unproven, and Oregon State has been gashed all year — there’s a strong case for points. Our oddschecker+ projections expect 50+ combined, making the over a sharp lean.
Bottom line: Houston is the better team and should get the win, but the Beavers at home catching nearly two touchdowns provide value. Oregon State +13.5 and Over 47.5 stand out as the sharpest ways to attack this Friday night Pac-12 matchup.
Houston vs. Oregon State Pick
- Pick: Oregon State +13.5 (-110) Click here to get the best odds at DraftKings Sportsbook
Click here to get the best odds at FanDuel Sportsbook
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