Ohio State vs. Washington Prediction, Betting Pick, Latest CFB Odds for Week 5 Big Ten Battle
The Washington Huskies will look to spoil the Ohio State Buckeyes perfect start as single-digit underdogs at home. It's a rare spot to see against a No. 1 team vs. an unranked squad, but Washington may be better than many people expect. McBets is not looking past Washington's potential, and explores their chances in this Ohio State vs. Washington prediction for Saturday, September 27th.
McBets - September 27, 2025, 2:00 PM EDT
4 Minute ReadOhio State vs. Washington Prediction: Can Huskies Stun Jeremiah Smith, Buckeyes on Saturday Afternoon?
Two unbeaten teams square off in Seattle on Saturday as the No. 1 Ohio State Buckeyes visit the unranked but dangerous Washington Huskies. Both squads are 3–0 and coming off a bye week, setting the stage for an afternoon clash between one of college football’s blue bloods and a Big Ten program still searching for national respect in their new conference.
Despite their perfect start, the Huskies remain outside the Top 25, a sign that oddsmakers and voters alike may be underrating what has been a sharp and balanced team. Now they get their chance to prove it against an Ohio State side that already owns a marquee win over Texas and looks every bit like a playoff favorite.
The Buckeyes will lean on Julian Sayin and star wideout Jeremiah Smith, a duo that has already terrorized secondaries across the country. Washington’s defense will need to rise to the occasion in front of a raucous home crowd if they want to pull the upset as a +8.5 underdog in the Pacific Northwest.
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Ohio State vs. Washington Odds
Ohio State vs. Washington Date, Time, and Where to Watch
- Date: Saturday, September 27, 2025
- Time: 3:30 PM ET
- Where to Watch: CBS
Click here for complete Ohio State vs. Washington odds
Ohio State vs. Washington Prediction
Husky Stadium is one of the toughest road environments in college football, and Washington has historically risen to the occasion at home against top-ranked teams. The energy of a prime-time game in Seattle will be a real factor for Ohio State, especially as the Buckeyes bring a young offense into a hostile setting.
Defensively, Washington has the tools to make this interesting. Their front seven has been effective at generating pressure, and they’ve limited explosive plays well this season. If they can force Ohio State into longer drives instead of quick strikes, they can shorten the game and keep things close.
Ohio State is loaded with talent, but they’ve also shown some offensive inconsistency this year. The Buckeyes have had stretches where penalties, turnovers, and protection issues have slowed them down. Washington’s defense is disciplined enough to take advantage if those mistakes show up again.
Offensively, Washington doesn’t have to be perfect to cover this number. Their run game and quick passing attack can help neutralize Ohio State’s pass rush and keep the chains moving. If they win time of possession and hit a few big plays, the Huskies can hang around well into the second half.
The spread sitting at over a TD also gives us plenty of cushion. Even if Ohio State pulls away late, Washington has enough offense to grab a backdoor cover with a final drive.
Ohio State vs. Washington Pick
- 2 Unit Pick: Washington +10 (-130) Click here to get the best odds at DraftKings Sportsbook
Ohio State may ultimately win, but all signs point to this game being closer than the oddsmakers expect. Washington has the home field, the defensive front, and the motivation to keep this one within the number.
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