New York Giants vs. San Francisco 49ers Prediction, Pick Against the Spread, and Latest Odds
The New York Giants and the San Francisco 49ers will duel things out on Thursday Night Football. Who has the edge? Matt McCuen shares his New York Giants vs. San Francisco 49ers prediction, pick, and the latest odds ahead of the game.
Matt McCuen - September 21, 2023, 11:27 AM EDT
7 minNew York Giants vs. San Francisco 49ers Prediction, Pick Against the Spread, and Latest Odds
The New York Giants and the San Francisco 49ers will duel things out on Thursday Night Football.
Giants vs. 49ers Date, Time, and Where to Watch
- Date: September 21, 2023
- Game Time: 8:15 pm ET
- Where to Watch: Prime Video
New York Giants vs. San Francisco 49ers Prediction
I have heard a lot of people complaining about this game, as many believe the Giants will get blown out by San Francisco.
My response to that is, who cares? We have football, and it is time to find a winner and get rich.
New York took the league by storm a season ago when they won nine games and reached the postseason.
Giants Head Coach Brian Dabol earned himself the Coach of the Year award as a result.
Entering 2023, there were a lot of questions about whether or not the Giants could maintain the same success from 2022.
New York defeated the Minnesota Vikings in the playoffs, but the Eagles would end their season in a blowout.
The Giants enter play with a 1-1 record on the young season after suffering a loss in Week 1 to the Dallas Cowboys, followed by a Week 2 win over the Arizona Cardinals.
San Francisco has been the most impressive team in football in the first couple of weeks.
I have the 49ers ranked as my best team in football in my Week 3 NFL power rankings.
The 49ers have high expectations as they have the best odds of any team in football to win the Super Bowl (+650)
San Francisco reached the NFC Championship game in 2022 but lost badly to the Philadelphia Eagles.
The 49ers blew out the Steelers in Week 2 and followed that up with a seven-point win over the Rams.
New York Giants vs. San Francisco 49ers Pick
San Francisco is the best defense in football.
The Giants are without their most dynamic playmaker, Saquon Barkley.
This means that the Giants will struggle to run the football, which will allow the pass rushers for San Francisco to work in favorable downs.
San Francisco loves to run the football, and they do it well.
The 9ers will run often early, which means the clock will be moving.
Even on drives that end in points, there will be a lot of clock used, which favors this play.
These two teams are a combined 0-4 on the under in the first half, but that will change tonight.
Pick: Giants/49ers 1H under 22.5 -105 is currently the best odds. Click here to see which sportsbook has the best odds for this pick
NFL Odds
