Cardinals vs. Buccaneers Prediction, Betting Pick, Latest NFL Odds for Week 13
The Tampa Bay Bucs were previously leading the NFC, but injuries have derailed their season. Are they in danger of missing the playoffs, or can Baker Mayfield and Chris Godwin get them back on track? Let's take a look at this Cardinals vs. Bucs prediction for Week 13.
OC Staff - November 30, 2025, 11:15 AM EST
4 Minute ReadCardinals vs. Buccaneers Prediction: Can Baker Mayfield, Bucs Get Back on Track at Home in Week 13?
As the NFL season hurtles towards its crucial latter stages, two teams grappling with mid-season slumps — the Arizona Cardinals (3-8, #13 in conference, Lost 3) and the Tampa Bay Buccaneers (6-5, #4 in conference, Lost 3) — prepare to clash, each desperate to snap their three-game losing streaks.
While the Buccaneers hold a precarious grip on a playoff spot with a 2-2 home record, the visiting Cardinals, with a 2-3 road record, are looking to play spoiler. This contest won't be about flashy plays, but rather a grinder's battle, where individual matchups will dictate the trajectory of desperate teams.
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Cardinals vs. Buccaneers Date, Time, and Where to Watch
- Date: Sunday, November 30, 2025
- Time: 1:00 PM ET
- How to Watch: FOX
Cardinals vs. Buccaneers Odds
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Cardinals vs. Buccaneers Prediction
The most striking contrast and arguably the game's pivotal matchup lies in the quarterback play. For the visiting Cardinals, Jacoby Brissett (QB) arrives with a projected stat line of 25 completions on 38 attempts for 263.8 yards and 0.6 interceptions. What truly stands out, however, are his historical splits against top-10 passing defenses: across four games, Brissett has maintained an impressive 93.8 Passer Rating, averaging a robust 293.5 passing yards per game, throwing 7 touchdowns to just 1 interception.
This suggests a quarterback capable of performing under pressure and against quality units. He'll face a Buccaneers defense ranked 21st against the pass (QB Rating Allowed) – a unit that, despite a respectable 12th-place ranking in pass rush, is far from a top-tier challenge for a quarterback of Brissett's historical resilience.
Conversely, Teddy Bridgewater (QB), leading the Buccaneers, faces a far more grim outlook. His projection for this game is a meager 7 completions on 14 attempts for 88.9 yards and 0.2 interceptions. His historical performance against top-10 passing defenses is equally concerning; in his lone such outing, he managed a paltry 63.8 Passer Rating and just 62.0 passing yards, without a single touchdown.
While the Cardinals' pass defense (ranked 16th in QB Rating Allowed) isn't elite, it's certainly not among the league's worst. Bridgewater's projected anemic output, even against a middling pass defense, suggests a significant struggle to move the ball through the air. This stark disparity in projected and historical performance under pressure between the two signal-callers will undeniably shape the game's narrative. If Brissett can leverage his historical success against tough defenses to exploit Tampa Bay's 21st-ranked pass defense, while Bridgewater falters against Arizona's 16th-ranked unit, the Cardinals could find an unexpected path to victory.
Another critical battle will unfold on the ground, specifically focusing on the Cardinals' primary ball-carrier, Bam Knight (RB1), against the Buccaneers' defensive front. Knight is projected to carry the ball 9.6 times for a modest 30.1 rushing yards. He'll be running against a Tampa Bay run defense that ranks 16th in rush yards per carry allowed, placing them squarely in the middle of the league. While a 16th-ranked run defense isn't impenetrable, Knight's low projection against such a unit suggests significant difficulty in finding consistent yardage.
Our model identifies a substantial gap in the market here, showing a strong edge for bettors: the model found a significant edge on Under 30.0 Rushing Yards for Bam Knight at 1.91 (-110) odds (EV: 19.3%). This high-value opportunity underscores the expectation that Knight will struggle to meet even a relatively low yardage total, indicating a potential inability for the Cardinals to establish a ground presence. If Tampa Bay's front seven effectively bottles up Knight, forcing Brissett into predictable passing situations, it could heavily tilt the game in the Buccaneers' favor, irrespective of Brissett's individual prowess.
The most decisive factor in this desperate clash will undoubtedly be the performance of the quarterbacks. Jacoby Brissett's historical ability to thrive against tougher defenses, paired with his solid projection against a sub-par Buccaneers secondary, presents a clear path for the Cardinals to keep pace or even pull ahead. Conversely, Teddy Bridgewater's projected struggles and historical anemic output against quality pass defenses, even against a middling Arizona unit, suggest the Buccaneers could be in for another challenging offensive outing.
While Bam Knight's anticipated difficulties on the ground (reinforced by the significant value on his Under 30.0 rushing yards prop) will hamper Arizona's offensive balance, the ability of Brissett to keep the chains moving through the air will be paramount. Ultimately, the Cardinals' offensive ceiling hinges on Brissett's arm, while the Buccaneers' chances rest on their defense containing him and hoping Bridgewater can defy his own projections.
Cardinals vs. Buccaneers Pick
- Pick: Under 44.5 Total Points (-110) Check out these best odds on DraftKings Sportsbook
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