Top 5 Betting Picks for Monday Night Football - Expert Predictions & Value Plays for 49ers vs. Colts
The Wolf has gathered the top 5 props from the oddschecker+ Positive EV Tool for Monday Night Football when the Colts host the 49ers as two teams fight for playoff positioning. Check out these best bets for Monday, December 22nd from Lucas Oil Stadium.
The Wolf - December 22, 2025, 11:00 AM EST
4 Minute ReadTop 5 Betting Picks for Monday Night Football - Finding Value with Alec Pierce, Brock Purdy on MNF
Sunday Night Football heads to Baltimore with urgency on both sidelines. The Patriots are coming off a stunning collapse last week, blowing a three-touchdown lead at home against Buffalo and snapping a 10-game win streak in brutal fashion. Now they walk into a hostile environment as +3.5 underdogs, trying to stabilize before things unravel further.
On the other side, the Ravens are desperate. Their playoff hopes are hanging by a thread in the AFC North, and this game sets up perfectly for a classic Baltimore script: get out early, control the trenches, and lean heavily on Derrick Henry. If that happens, New England will be forced into catch-up mode behind Drake Maye, spreading targets to secondary pass-catchers like DeMario Douglas and Austin Hooper while Baltimore focuses its coverage elsewhere. That game flow is exactly where The Wolf finds value.
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49ers vs. Colts Date, Time, and Where to Watch
- Date: Monday, December 22, 2025
- Time: 8:15 PM ET
- How to Watch: ESPN
49ers vs. Colts Odds
Click here for the latest 49ers vs. Colts odds
The Wolf Top 5 Betting Picks - Monday Night Football - 49ers vs. Colts
1. Alec Pierce Over 1.5 Receptions (-138) Check out the best odds at FanDuel Sportsbook
- AI Probability: 78.98%
- EV: +36.21%
- Trend: Hit in 8 of last 10 games
This is a classic “QB change discount” spot. With Rivers back, the Colts are not asking him to carve defenses apart. They want quick reads, rhythm throws, and chain-moving completions. Pierce fits that profile perfectly. Two catches is all we need, and the AI sees this as one of the strongest edges on the board.
2. Brock Purdy Over 9.5 Rushing Yards (-110) Check out the best odds at BetMGM Sportsbook
- AI Probability: 63.99%
- EV: +22.22%
- Trend: Hit in 7 of last 10 games
Purdy is not a runner by design, but he is excellent at extending plays and stealing yards when lanes open. Against a Colts defense that plays disciplined coverage but lacks elite edge pressure, Purdy should have multiple scramble opportunities.
3. Tyler Warren Over 14.5 Longest Reception (-125) Check out the best odds at BetMGM Sportsbook
- AI Probability: 66.09%
- EV: +18.96%
- Trend: Hit in 7 of last 10 games
With Rivers back, the Colts are not pushing consistent vertical volume. But that does not eliminate chunk plays off play-action or busted coverage. Warren’s longest catch prop stays depressed because of quarterback uncertainty, yet the role remains intact.
One seam route, one blown assignment, cash.
4. Brock Purdy Under 33.5 Passing Attempts (-120) Check out the best odds at FanDuel Sportsbook
- AI Probability: 64.44%
- EV: +18.14%
- Trend: Under in 6 of last 10 games
This game script screams balance. San Francisco will lean on its run game, control tempo, and avoid unnecessary exposure against a Colts offense still finding its footing. If the 49ers play from ahead or neutral, Purdy’s volume stays capped.
5. George Kittle Under 67.5 Receiving Yards (-108) Check out the best odds at Caesars Sportsbook
- AI Probability: 56.6%
- EV: +9.24%
- Trend: Under in 7 of last 10 games
Kittle remains elite, but his role has become more situational than explosive. With the 49ers spreading targets and emphasizing run control, Kittle’s ceiling games are rarer. The Colts also tend to bracket tight ends in the red zone, forcing yards elsewhere.
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