Thiago Agustin Tirante vs. Daniil Medvedev Prediction, Betting Pick, Latest Italian Open Odds for Tuesday, May 12th
Daniil Medvedev might have survived on Monday, but he's on upset alert for Tuesday's Round of 16 at the Italian Open. Can Thiago Agustin Tirante continue his hot streak and upset the Russian star? Let's take a look at this Thiago Agustin Tirante vs. Daniil Medvedev prediction and best betting pick for Tuesday, May 12th at the Italian Open in Rome.
Peter Alexis - May 12, 2026, 8:30 AM EDT
4 Minute ReadThiago Agustin Tirante vs. Daniil Medvedev Prediction: Can Underdog Surprise Medvedev in Italian Open Round of 16 on Tuesday Afternoon?
Thiago Agustin Tirante meets Daniil Medvedev on Tuesday, May 12, at 2:30 p.m. ET in the Round of 16 at the ATP Rome Italian Open. Medvedev is favored at -172, while Tirante comes back at +150 after delivering one of the most impressive results of his career in the previous round.
The over is a strong lean after both players were pushed on Monday, but the better value sits with Tirante on the moneyline. Medvedev survived Pablo Llamas Ruiz in three sets after dropping the opener, while Tirante stunned home favorite Flavio Cobolli 6-4, 6-4 to reach the last 16 of a Masters 1000 for the first time.
Looking for advanced AI predictions and props to enhance your betting? Try out oddschecker+ now on this limited time 7-day free trial!
Thiago Agustin Tirante vs. Daniil Medvedev Odds
- Moneyline: Tirante (+150), Medvedev (-172)
Thiago Agustin Tirante vs. Daniil Medvedev Date, Time, and Where to Watch
- Date: Tuesday, May 12th, 2026
- Time: 2:30 PM ET
- Where to Watch: Tennis Channel
Click here for complete Tirante vs. Medvedev Odds
Thiago Agustin Tirante vs. Daniil Medvedev Prediction
Medvedev’s Rome run has already shown the risk in laying a short favorite price. He beat Llamas Ruiz 3-6, 6-4, 6-2, but the slow start was another reminder that clay still does not bring out his most reliable version. Medvedev can adjust tactically, extend rallies, and wear down lesser opponents, but he is also vulnerable to frustration when he is not getting free points or when an opponent forces him to create offense on slower courts.
Tirante enters with real momentum. Beating Cobolli in straight sets in Rome required poise, aggression, and the ability to handle a crowd fully behind the Italian. He also reached this stage after already getting through Cameron Norrie earlier in the tournament, giving him multiple quality wins and a clear belief that he can extend this run. The underdog is not just hanging around the draw. He is actively taking out higher-profile opponents.
The quick turnaround adds another layer. Medvedev had to work for more than two hours against Llamas Ruiz, while Tirante also had to manage the physical and emotional lift of beating Cobolli. That makes the over tempting, especially if both players need time to settle. But if Medvedev starts slowly again, this matchup could flip quickly. Tirante has the clay rhythm, confidence, and crowd-pressure experience from Monday to take advantage before Medvedev finds control.
Thiago Agustin Tirante vs. Daniil Medvedev Best Bet
- Best Bet: Thiago Agustin Tirante Moneyline (+150) Check out the best odds at DraftKings Sportsbook
Medvedev is still the bigger name and more accomplished player, but this is exactly the kind of clay-court spot where his level can dip. Tirante is surging, Medvedev is coming off a shaky three-set escape, and the underdog has already shown he can handle the moment in Rome. At plus money, Tirante is worth backing to continue his upset run.
More Tennis Odds
Affiliate Disclosure.
We are not a gambling or betting operator, but we receive a commission from these companies when we advertise their brands and refer customers to them (affiliate marketing). We provide information, odds information and links to websites of these companies. Some of the information made available on our site may be positioned as a result of a commission paid to us by a third party. We do not take or place bets/transactions and any information on Our Products is provided for entertainment purposes only.
