The Dallas Cowboys and New York Giants close Sunday's slate with an NFC East rivalry game under the lights at MetLife Stadium. Dak Prescott leads a Dallas offense loaded with receiving talent, while Jaxson Dart begins Year 2 with Malik Nabers potentially returning for John Harbaugh's Giants debut. Check out this Cowboys vs. Giants prediction and best bet for Sunday, September 13.

The Green Bay Packers and Minnesota Vikings renew their NFC North rivalry with one of Sunday's tightest spreads. Jordan Love leads Green Bay into Minneapolis, while Kyler Murray makes his Vikings debut surrounded by Justin Jefferson, Jordan Addison and a healthy Minnesota offensive line. Check out this Packers vs. Vikings prediction and best bet for Sunday, September 13.

The Washington Commanders and Philadelphia Eagles open the season with an NFC East matchup that brings Jayden Daniels back into the rivalry after an injury-shortened 2025. Philadelphia remains the division favorite behind Jalen Hurts, Saquon Barkley and Vic Fangio's defense, while both offenses enter with new coordinators. Check out this Commanders vs. Eagles prediction and best bet for Sunday, September 13.

The Arizona Cardinals begin the Mike LaFleur era against a Los Angeles Chargers team coming off consecutive 11-win seasons. Jacoby Brissett, Trey McBride and Marvin Harrison Jr. give Arizona enough proven offensive pieces to test a large spread, while Justin Herbert debuts in Mike McDaniel's new offense. Check out this Cardinals vs. Chargers prediction and best bet for Sunday, September 13.

Read our San Diego FC vs Philadelphia Union prediction with latest odds, lineups, top betting picks, and Same Game Parlay insights for Sunday's MLS game.

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